Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. [PDF]
PLoS Pathogens, 2014 Kaposi's sarcoma associated herpesvirus (KSHV) is etiologically associated with endothelial Kaposi's sarcoma (KS) and B-cell proliferative primary effusion lymphoma (PEL), common malignancies seen in immunocompromised HIV-1 infected patients.
Mohanan Valiya Veettil +7 more
doaj +2 more sources
Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes. [PDF]
PLoS ONE, 2013 Several epidemiological studies have suggested a link between melanoma and breast cancer. Metabotropic glutamate receptor 1 (GRM1), which is involved in many cellular processes including proliferation and differentiation, has been implicated in ...
Madhura S Mehta +16 more
doaj +2 more sources
Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait. [PDF]
Curr Biol, 2021 Shi G +9 more
europepmc +2 more sources
Metabotropic glutamate receptor 1 recycles to the cell surface in protein phosphatase 2A‐dependent manner in non‐neuronal and neuronal cell lines [PDF]
Journal of Neurochemistry, 2014 Saurabh Pandey +2 more
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Exosomes released by metabotropic glutamate receptor 1 (GRM1) expressing melanoma cells increase cell migration and invasiveness. [PDF]
Oncotarget, 2018 Exosomes are naturally occurring membrane-bound nanovesicles generated constitutively and released by various cell types, and often in higher quantities by tumor cells.
Isola AL +4 more
europepmc +2 more sources
Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. [PDF]
Oncotarget, 2017 Recent evidence suggests that glutamate signaling plays an important role in cancer. Riluzole is a glutamate release inhibitor and FDA-approved drug for the treatment of amyotrophic lateral sclerosis.
Dolfi SC +10 more
europepmc +2 more sources
Phosphorylation and Feedback Regulation of Metabotropic Glutamate Receptor 1 by Calcium/Calmodulin-Dependent Protein Kinase II [PDF]
Journal of Neuroscience, 2013 The metabotropic glutamate receptor 1 (mGluR1) is a Gαq-protein-coupled receptor and is distributed in broad regions of the mammalian brain. As a key element in excitatory synaptic transmission, the receptor regulates a wide range of cellular and ...
Dao-Zhong Jin +6 more
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AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1) [PDF]
Pigment Cell & Melanoma Research, 2009 We reported earlier on the oncogenic properties of Grm1 by demonstrating that stable Grm1‐mouse‐melanocytic clones proliferate in the absence of growth supplement and anchorage in vitro.
Seung‐Shick Shin +3 more
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The Protective Signaling of Metabotropic Glutamate Receptor 1 Is Mediated by Sustained, β-Arrestin-1-dependent ERK Phosphorylation [PDF]
Journal of Biological Chemistry, 2010 Metabotropic glutamate receptor 1 (mGlu1) is a G protein-coupled receptor that enhances the hydrolysis of membrane phosphoinositides. In addition to its role in synaptic transmission and plasticity, mGlu1 has been shown to be involved in neuroprotection ...
Andrew C. Emery +5 more
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Investigation of allosteric modulation mechanism of metabotropic glutamate receptor 1 by molecular dynamics simulations, free energy and weak interaction analysis. [PDF]
Sci Rep, 2016 Metabotropic glutamate receptor 1 (mGlu1), which belongs to class C G protein-coupled receptors (GPCRs), can be coupled with G protein to transfer extracellular signal by dimerization and allosteric regulation. Unraveling the dimer packing and allosteric
Bai Q, Yao X.
europepmc +2 more sources