Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. [PDF]
PLoS Pathogens, 2014 Kaposi's sarcoma associated herpesvirus (KSHV) is etiologically associated with endothelial Kaposi's sarcoma (KS) and B-cell proliferative primary effusion lymphoma (PEL), common malignancies seen in immunocompromised HIV-1 infected patients.
Mohanan Valiya Veettil +7 more
doaj +3 more sources
An Essential Role of Fyn in the Modulation of Metabotropic Glutamate Receptor 1 in Neurons. [PDF]
eNeuro, 2017 AbstractFyn is a member of the Src family of nonreceptor tyrosine kinases and is broadly expressed in the CNS. As a synapse-enriched kinase, Fyn interacts with and phosphorylates local substrates to regulate synaptic transmission and plasticity, although our knowledge of specific targets of Fyn at synaptic sites remains incomplete and the accurate role
Jin DZ, Mao LM, Wang JQ.
europepmc +5 more sources
Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins [PDF]
BMC Neuroscience, 2006 Background Metabotropic glutamate receptors (mGluRs) regulate neuronal excitability and synaptic strength. The group I mGluRs, mGluR1 and 5, are widespread in the brain and localize to post-synaptic sites. The Homer protein family regulates group I mGluR
Kammermeier Paul J
doaj +4 more sources
Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer. [PDF]
Sci Rep, 2018 AbstractBreast cancer remains a major cause of death among women. 15% of these cancers are triple negative breast cancer (TNBC), an aggressive subtype of breast cancer for which no current effective targeted therapy exists. We have previously demonstrated a role for mGluR1 in mediating tumor cell growth, endothelial cell proliferation, and tumor ...
Sexton RE +5 more
europepmc +5 more sources
Cys-140 Is Critical for Metabotropic Glutamate Receptor-1 Dimerization [PDF]
Journal of Biological Chemistry, 2000 Metabotropic glutamate receptor 1 (mGluR1) expresses at the cell surface as disulfide-linked dimers and can be reduced to monomers with sulfhydryl reagents. To identify the dimerization domain, we transiently expressed in HEK-293 cells a truncated version of mGluR1 (RhodC-R1) devoid of the extracellular domain (ECD).
Benjamin C. Hauschild, Kausik Ray
openaire +5 more sources
A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation [PDF]
Scientific Reports, 2017 Mechanical pain serves as a base clinical symptom for many of the world’s most debilitating syndromes. Ion channels expressed by peripheral sensory neurons largely contribute to mechanical hypersensitivity.
Allison Doyle Brackley +7 more
doaj +2 more sources
Metabotropic glutamate receptor 1 alpha: a unique receptor variant with variable implications for Alzheimer's disease pathogenesis. [PDF]
Neural Regen Res, 2023 Yeung JH, Kwakowsky A.
europepmc +2 more sources
Cholesterol Dependence of the Conformational Changes in Metabotropic Glutamate Receptor 1 [PDF]
AbstractMetabotropic glutamate receptors (mGluRs) are class C G protein-coupled receptors that function as obligate dimers in regulating neurotransmission and synaptic plasticity in the central nervous system. The mGluR1 subtype has been shown to be modulated by the membrane lipid environment, particularly cholesterol, though the molecular mechanisms ...
Ugochi H, Isu +5 more
openaire +3 more sources
Modulatory effects of Ampicillin/Sulbactam on glial glutamate transporters and metabotropic glutamate receptor 1 as well as reinstatement to cocaine-seeking behavior. [PDF]
Behav Brain Res, 2017 Hammad AM +3 more
europepmc +3 more sources
Anti-mGluR1 encephalitis: Case illustration and systematic review
Frontiers in Neurology, 2023 BackgroundThe literature for immune-mediated neurological disorders is evolving like no other field of neurological illnesses. Many new antibodies or disorders have been described in the last decade.
Osama Khojah +6 more
doaj +1 more source