Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait [PDF]
Current Biology, 2021 Sufficient and efficient sleep is crucial for our health. Natural short sleepers can sleep significantly shorter than the average population without a desire for more sleep and without any obvious negative health consequences. In searching for genetic variants underlying the short sleep trait, we found two different mutations in the same gene ...
Guangsen Shi +9 more
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An Essential Role of Fyn in the Modulation of Metabotropic Glutamate Receptor 1 in Neurons [PDF]
eneuro, 2017 AbstractFyn is a member of the Src family of nonreceptor tyrosine kinases and is broadly expressed in the CNS. As a synapse-enriched kinase, Fyn interacts with and phosphorylates local substrates to regulate synaptic transmission and plasticity, although our knowledge of specific targets of Fyn at synaptic sites remains incomplete and the accurate role
John Q. Wang +3 more
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Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer [PDF]
Scientific Reports, 2018 AbstractBreast cancer remains a major cause of death among women. 15% of these cancers are triple negative breast cancer (TNBC), an aggressive subtype of breast cancer for which no current effective targeted therapy exists. We have previously demonstrated a role for mGluR1 in mediating tumor cell growth, endothelial cell proliferation, and tumor ...
Rachel E. Sexton +5 more
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Metabotropic Glutamate Receptor-1 as a Novel Target for the Antiangiogenic Treatment of Breast Cancer [PDF]
PLoS ONE, 2014 Metabotropic glutamate receptors (mGluRs) are normally expressed in the central nervous system, where they mediate neuronal excitability and neurotransmitter release. Certain cancers, including melanoma and gliomas, express various mGluR subtypes that have been implicated as playing a role in disease progression.
John A. DeVries +5 more
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Metabotropic glutamate receptor 1 alpha: a unique receptor variant with variable implications for Alzheimer’s disease pathogenesis [PDF]
Neural Regen Res, 2023 Andrea Kwakowsky, JasonHY Yeung
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MGlu5 Dependent Mitochondrial Translocation of PKCδ: A Mechanism Raising Astrocytic Oxidative Metabolism in Response to Extracellular Glutamate [PDF]
Journal of Neurochemistry, Volume 169, Issue 8, August 2025.The observations suggest a new mechanism, the mGluR5/PKCδ/PDH axis by which extracellular glutamate can raise oxidative metabolism in astrocytes, in response to rapidly increasing energy demands, such as in the liver or skeletal muscle. It appears that the plethora of astrocytic mitochondria maintain only a basal level of oxidative metabolism during ...
Kiavasch M. N. Farid +3 more
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Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease Patients [PDF]
PROTEOMICS, Volume 25, Issue 15, Page 42-49, August 2025.ABSTRACT One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal proteome in humans is unknown.
Ivo Fabrik +12 more
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Modulatory effects of Ampicillin/Sulbactam on glial glutamate transporters and metabotropic glutamate receptor 1 as well as reinstatement to cocaine-seeking behavior [PDF]
Behav Brain Res, 2017 Alaa M. Hammad +3 more
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Group 1 metabotropic glutamate receptors and schizophrenia [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2011 AbstractSchizophrenia is a prevalent neuropsychiatric disorder associated with perturbations in medial prefrontal cortex (PFC) excitability and connectivity. As such, research into the neurobiology of schizophrenia and related psychotic disorders has focused on understanding the possible role played by the major excitatory neurotransmitter glutamate in
DE BARTOLOMEIS, ANDREA, Szumlinski K. K.
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Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus [PDF]
Molecular Pharmacology, 2016 The delta family of ionotropic glutamate receptors consists of glutamate delta-1 (GluD1) and glutamate delta-2 receptors. We have previously shown that GluD1 knockout mice exhibit features of developmental delay, including impaired spine pruning and switch in the N-methyl-D-aspartate receptor subunit, which are relevant to autism and other ...
Subhash C. Gupta +5 more
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