Results 11 to 20 of about 54,745 (192)
Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait [PDF]
Current Biology, 2021 Sufficient and efficient sleep is crucial for our health. Natural short sleepers can sleep significantly shorter than the average population without a desire for more sleep and without any obvious negative health consequences. In searching for genetic variants underlying the short sleep trait, we found two different mutations in the same gene ...
Guangsen Shi +9 more
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Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer [PDF]
Scientific Reports, 2018 AbstractBreast cancer remains a major cause of death among women. 15% of these cancers are triple negative breast cancer (TNBC), an aggressive subtype of breast cancer for which no current effective targeted therapy exists. We have previously demonstrated a role for mGluR1 in mediating tumor cell growth, endothelial cell proliferation, and tumor ...
Rachel E. Sexton +5 more
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Metabotropic Glutamate Receptor 1 and Glutamate Signaling in Human Melanoma [PDF]
Cancer Research, 2007 Abstract Recently, several laboratories have started to investigate the involvement of glutamate signaling in cancer. In previous studies, we reported on a transgenic mouse model that develops melanoma spontaneously. Subsequent studies in these mice identified that the aberrant expression of metabotropic glutamate receptor 1 (GRM1) in ...
Jin, Namkoong +6 more
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GRM1 (glutamate receptor, metabotropic 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014 Review on GRM1, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
Sierra, J, Chen, S
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Metabotropic glutamate receptor type 1 in taste tissue [PDF]
The American Journal of Clinical Nutrition, 2009 l-Glutamate confers cognitive discrimination for umami taste (delicious or savory) and dietary information to the brain through the activation of G protein-coupled receptors in specialized taste receptor cells of the tongue. The taste heterologous receptor T1R1 plus T1R3 is not sufficient to detect umami taste in mice.
Ana, San Gabriel +3 more
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Metabotropic glutamate receptor type 1 autoimmunity [PDF]
Neurology, 2016 To describe retrospectively the clinical associations of immunoglobulin G (IgG) targeting metabotropic glutamate receptor 1 (mGluR1-IgG).Specimens of 9 patients evaluated on a service basis in the Mayo Clinic Neuroimmunology Laboratory by tissue-based immunofluorescence assay (IFA) yielded a robust, synaptic immunostaining pattern consistent with ...
A Sebastian, Lopez-Chiriboga +6 more
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Activation of Metabotropic Glutamate Receptor 1 Accelerates NMDA Receptor Trafficking [PDF]
The Journal of Neuroscience, 2001 Regulation of neuronal NMDA receptors (NMDARs) by group I metabotropic glutamate receptors (mGluRs) is known to play a critical role in synaptic transmission. The molecular mechanisms underlying mGluR1-mediated potentiation of NMDARs are as yet unclear.
J Y, Lan +5 more
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Group 1 metabotropic glutamate receptors and schizophrenia [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2011 AbstractSchizophrenia is a prevalent neuropsychiatric disorder associated with perturbations in medial prefrontal cortex (PFC) excitability and connectivity. As such, research into the neurobiology of schizophrenia and related psychotic disorders has focused on understanding the possible role played by the major excitatory neurotransmitter glutamate in
DE BARTOLOMEIS, ANDREA, Szumlinski K. K.
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Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus [PDF]
Molecular Pharmacology, 2016 The delta family of ionotropic glutamate receptors consists of glutamate delta-1 (GluD1) and glutamate delta-2 receptors. We have previously shown that GluD1 knockout mice exhibit features of developmental delay, including impaired spine pruning and switch in the N-methyl-D-aspartate receptor subunit, which are relevant to autism and other ...
Pratyush S, Suryavanshi +5 more
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mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]
, 2018 Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua +9 more
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