Results 11 to 20 of about 1,029 (201)
Neurobiology of Disease, 2014 Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease reflecting degeneration of upper and lower motoneurons (MNs).
Marco Milanese +11 more
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Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells [PDF]
Oncogene, 2012 Non-neuronal expression of components of the glutamatergic system has been increasingly observed, and our laboratory previously had demonstrated the etiological role of ectopically expressed metabotropic glutamate receptor 1 (Grm1/mGluR1) in mouse models of melanoma.
Martino, Jeffrey J +7 more
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AgRP/NPY Neuron Excitability Is Modulated by Metabotropic Glutamate Receptor 1 During Fasting [PDF]
Frontiers in Cellular Neuroscience, 2018 The potential to control feeding behavior via hypothalamic AgRP/NPY neurons has led to many approaches to modulate their excitability—particularly by glutamatergic input.
Brenton T. Laing +17 more
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Negative Cooperativity of Glutamate Binding in the Dimeric Metabotropic Glutamate Receptor Subtype 1 [PDF]
Journal of Biological Chemistry, 2004 Metabotropic glutamate receptor (mGluR) subtype 1 is a Class III G-protein-coupled receptor that is mainly expressed on the post-synaptic membrane of neuronal cells. The receptor has a large N-terminal extracellular ligand binding domain that forms a homodimer, however, the intersubunit communication of ligand binding in the dimer remains unknown. Here,
Yoshikazu, Suzuki +3 more
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Metabotropic Glutamate Receptors, PLCbeta 1 Signalling and Hippocampal Epileptiform Discharges [PDF]
Epilepsy Currents, 2002 Group I Metabotropic Glutamate Receptors Elicit Epileptiform Discharges in the Hippocampus Through PLCbeta1 Signaling Chuang SC, Bianchi R, Kim D, Shin HS, Wong RK J Neurosci 2001;21:6387–6394 Activation of metabotropic glutamate receptors (mGluRs) produces multiple effects in cortical neurons, resulting in the emergence of network activities ...
Larry S. Benardo
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Activation of Metabotropic Glutamate Receptor 1 Accelerates NMDA Receptor Trafficking [PDF]
The Journal of Neuroscience, 2001 Regulation of neuronal NMDA receptors (NMDARs) by group I metabotropic glutamate receptors (mGluRs) is known to play a critical role in synaptic transmission. The molecular mechanisms underlying mGluR1-mediated potentiation of NMDARs are as yet unclear.
J Y, Lan +5 more
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AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1) [PDF]
Pigment Cell & Melanoma Research, 2009 Seung-Shick Shin +3 more
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PLoS ONE, 2021 Crustaceans are major constituents of aquatic ecosystems and, as such, changes in their behavior and the structure and function of their bodies can serve as indicators of alterations in their immediate environment, such as those associated with climate ...
Jonathan L Crooke-Rosado +4 more
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Cys-140 Is Critical for Metabotropic Glutamate Receptor-1 Dimerization [PDF]
Journal of Biological Chemistry, 2000 Metabotropic glutamate receptor 1 (mGluR1) expresses at the cell surface as disulfide-linked dimers and can be reduced to monomers with sulfhydryl reagents. To identify the dimerization domain, we transiently expressed in HEK-293 cells a truncated version of mGluR1 (RhodC-R1) devoid of the extracellular domain (ECD).
K, Ray, B C, Hauschild
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Metabotropic glutamate receptor type 1 autoimmunity [PDF]
Neurology, 2016 To describe retrospectively the clinical associations of immunoglobulin G (IgG) targeting metabotropic glutamate receptor 1 (mGluR1-IgG).Specimens of 9 patients evaluated on a service basis in the Mayo Clinic Neuroimmunology Laboratory by tissue-based immunofluorescence assay (IFA) yielded a robust, synaptic immunostaining pattern consistent with ...
A Sebastian, Lopez-Chiriboga +6 more
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