Results 251 to 260 of about 52,371 (282)

Identification of the metabotropic glutamate receptor-1 protein in the rat trigeminal ganglion

Brain Research, 1993
Anti-metabotropic glutamate receptor-1 monoclonal antibody was raised and applied for immunohistochemistry in the rat trigeminal ganglion. The antibody detected 145-kDa single band of protein in the immunoblot analysis. In immunohistochemistry, neurons in the trigeminal ganglion showed immunostaining with various intensity, almost irrespective of their
Ryoichi Yoshimura, Hiroyuki Sugiyama, Atsushi Nishimune, James G. Kenimer, Toshiyuki Araki, Hiroshi Kiyama   +5 more
openaire   +3 more sources

Atypical signaling of metabotropic glutamate receptor 1 in human melanoma cells

Biochemical Pharmacology, 2015
The metabotropic glutamate 1 (mGlu1) receptor has emerged as a novel target for the treatment of metastatic melanoma and various other cancers. Our laboratory has demonstrated that a selective, non-competitive mGlu1 receptor antagonist slows human melanoma growth in vitro and in vivo.
Sergey Pshenichkin, Carrie Bowman Dalley, Hannah A. Hathaway, Barry B. Wolfe, Tara Gelb, Jarda T. Wroblewski, Ewa Grajkowska   +6 more
openaire   +3 more sources

Involvement of metabotropic glutamate receptor�1, a G protein coupled receptor, in melanoma development [PDF]

Journal of Molecular Medicine, 2004
Melanoma is the aberrant proliferation of melanocytes, the cells in the skin responsible for pigment production. In the United States the current lifetime risk of melanoma development is 1 in 57 in males and 1 in 81 in females. In its early stages melanoma can be surgically removed with great success; however, advanced stages of melanoma have a high ...
Yarí E. Marín, Suzie Chen
openaire   +2 more sources

Competitive Antagonism by Phenylglycine Derivatives at Type 1 Metabotropic Glutamate Receptors

Molecular and Cellular Neuroscience, 1994
Abstract The metabotropic glutamate receptors (mGluRs) form a family of G-protein-coupled receptors which consists of at least seven members termed mGluR1-mGluR7. These members are classified into subfamilies according to their sequence similarities, signal transduction mechanisms and agonist selectivities.
Ferraguti F., Cavanni P., Eistetter H., Salvagno C., Ratti E., Trist D. G.   +5 more
openaire   +3 more sources

Relationship between type 1 metabotropic glutamate receptors and cerebellar ataxia

Journal of Neurology, 2016
Imaging of type 1 metabotropic glutamate receptor (mGluR1) has recently become possible using positron emission tomography (PET). We aimed to examine the relationship between mGluR1 and cerebellar ataxia. Families with spinocerebellar ataxia type 19/22 (SCA19/22) and SCA6, six patients with sporadic SCA, and 26 healthy subjects underwent PET using an ...
Jun Toyohara, Ming-Rong Zhang, Yoshiharu Miura, Kinya Ishikawa, Kiichi Ishiwata, Kenji Ishibashi, Kenji Ishii   +6 more
openaire   +3 more sources

Activation of Metabotropic Glutamate Receptor 1 Dimers Requires Glutamate Binding in Both Subunits

The Journal of Pharmacology and Experimental Therapeutics, 2005
Group I metabotropic glutamate receptors (mGluRs) form stable, disulfide-linked homodimers. Lack of a verifiably monomeric mGluR1 mutant has led to difficulty in assessing the role of dimerization in the molecular mechanism of mGluR1 activation.
June Yun, Paul J. Kammermeier
openaire   +3 more sources

Metabotropic glutamate receptor 1 in human malignancies

2013
The role of the glutamatergic system in cancer cell homeostasis has expanded exponentially over the last decade. Once thought to participate only in synaptic transmission and neuronal excitability, the presence of functional glutamate receptors has since been demonstrated in peripheral tissues. Most notable is the implication of glutamatergic signaling
openaire   +2 more sources

The metabotropic glutamate receptor 1 is not involved in the facilitation of glutamate release in cerebrocortical nerve terminals

Neuropharmacology, 1998
In this study we have addressed the identification of the metabotropic glutamate receptor (mGluR) involved in the facilitation of glutamate release in nerve terminals from the cerebral cortex. mGluR1 and 5 are coupled to phosphoinositide hydrolysis and the activation of these receptors with the specific agonist 3,5-dihydroxyphenylglycine (DHPG ...
Alessandra Sistiaga, José Sánchez-Prieto, F Conquet, Inmaculada Herrero   +3 more
openaire   +3 more sources

Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine

Neuroscience, 1998
Previous work has shown that responses of thalamic neurons in vivo to the metabotropic glutamate receptor agonists 1S,3R-aminocyclopentane-1,3-dicarboxylate and S-3,5-dihydroxyphenylglycine can be reduced by a variety of phenylglycine antagonists. Responses of thalamic neurons to noxious thermal somatosensory stimuli were reduced in parallel by these ...
Salt, T. E., Turner, J. P.
openaire   +3 more sources

CPCCOEt, a Noncompetitive Metabotropic Glutamate Receptor 1 Antagonist, Inhibits Receptor Signaling Without Affecting Glutamate Binding

Molecular Pharmacology, 1999
Metabotropic glutamate receptors (mGluRs) are a family of G protein-coupled receptors characterized by a large, extracellular N-terminal domain comprising the glutamate-binding site. In the current study, we examined the pharmacological profile and site of action of the non-amino-acid antagonist 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ...
S, Litschig, F, Gasparini, D, Rueegg, N, Stoehr, P J, Flor, I, Vranesic, L, Prézeau, J P, Pin, C, Thomsen, R, Kuhn   +9 more
openaire   +2 more sources