Results 21 to 30 of about 54,745 (192)

Cys-140 Is Critical for Metabotropic Glutamate Receptor-1 Dimerization [PDF]

Journal of Biological Chemistry, 2000
Metabotropic glutamate receptor 1 (mGluR1) expresses at the cell surface as disulfide-linked dimers and can be reduced to monomers with sulfhydryl reagents. To identify the dimerization domain, we transiently expressed in HEK-293 cells a truncated version of mGluR1 (RhodC-R1) devoid of the extracellular domain (ECD).
K, Ray, B C, Hauschild
openaire   +2 more sources

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]

, 2018
In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba, Cristina Zappulla, Ferdinando Nicoletti, Francesca Liberatore, Giada Mascio, Giorgio Carmignoto, Giuseppe Battaglia, Harumi Nakao, Marta Motolese, Masahiko Watanabe, Micaela Zonta, Michele Madonna, Milena Cannella, Pamela Scarselli, Roberto Gradini, Serena Notartomaso, Valeria Bruno   +16 more
core   +2 more sources

Sequences within the C terminus of the metabotropic glutamate receptor 5 (mGluR5) are responsible for inner nuclear membrane localization [PDF]

, 2017
Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm.
Harmon, Steven K., Jong, Yuh-Jiin I., Kumar, Vikas, O\u27Malley, Karen L., Sergin, Ismail   +4 more
core   +2 more sources

Incentive learning underlying cocaine relapse requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons [PDF]

, 2010
Understanding the psychobiological basis of relapse remains a challenge in developing therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to environmental stimuli previously associated with drug taking.
Bilbao, Ainhoa, Chai, Minqiang, Crombag, Hans, Engblom, David, Halbout, Briac, Novak, Martin, O'Connor, Eoin, Parkitna, Jan Rodriguez, Schütz, Günther, Spanagel, Rainer, Stephens, David N, Su, Tian   +11 more
core   +2 more sources

Metabotropic Glutamate Receptors, PLCbeta 1 Signalling and Hippocampal Epileptiform Discharges [PDF]

Epilepsy Currents, 2002
Group I Metabotropic Glutamate Receptors Elicit Epileptiform Discharges in the Hippocampus Through PLCbeta1 Signaling Chuang SC, Bianchi R, Kim D, Shin HS, Wong RK J Neurosci 2001;21:6387–6394 Activation of metabotropic glutamate receptors (mGluRs) produces multiple effects in cortical neurons, resulting in the emergence of network activities ...
openaire   +2 more sources

Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. [PDF]

, 2014
BackgroundIn dementia with Lewy bodies (DLB) abnormal interactions between α-synuclein (α-syn) and beta amyloid (Aβ) result in selective degeneration of neurons in the neocortex, limbic system and striatum.
Cartier, Anna, Desplats, Paula, Masliah, Eliezer, Overk, Cassia R, Patrick, Christina, Price, Diana L, Rockenstein, Edward, Shaked, Gideon, Spencer, Brian, Ubhi, Kiren   +9 more
core   +3 more sources

Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation [PDF]

Pigment Cell & Melanoma Research, 2008
SummaryPreviously, we reported a transgenic mouse line, TG‐3, that develops spontaneous melanoma with 100% penetrance. We demonstrated that ectopic expression of Grm1 in melanocytes was sufficient to induce melanoma in vivo. In this present study, the transforming properties of Grm1 in two cultured immortalized melanocytes were investigated.
Seung-Shick, Shin, Jin, Namkoong, Brian A, Wall, Ryan, Gleason, Hwa Jin, Lee, Suzie, Chen   +5 more
openaire   +2 more sources

Reduction in Phencyclidine Induced Sensorimotor Gating Deficits in the Rat Following Increased System Xc − Activity in the Medial Prefrontal Cortex [PDF]

, 2013
Rationale: Aspects of schizophrenia, including deficits in sensorimotor gating, have been linked to glutamate dysfunction and/or oxidative stress in the prefrontal cortex. System xc −, a cystine–glutamate antiporter, is a poorly understood mechanism that
A Araque, A Kulak, A Wilmsmeier, B Moghaddam, B Moghaddam, B Oranje, BJ Morris, D Braff, D Lobner, D Matsuzawa, D Piani, DA Baker, DA Baker, David A. Baker, DH Ingvar, DL Braff, DV Pow, FK Graham, G Battaglia, G Franzen, G Paxinos, G Paxinos, G Rajkowska, HH Chen, J Cilia, JA Lieberman, JH Cabungcal, JI Sagara, Jon Resch, JT Coyle, K Japha, K Moussawi, K Moussawi, K Ogita, K Schwabe, K Shimosato, KE Poskanzer, KF Berman, KQ Do, Krista Qualmann, KS Kau, L Deserno, L Pasti, LA Glantz, Linghai Kong, LJ Garey, M Berk, M Berk, M Koch, M Li, M Raffa, MA Geyer, MC Angulo, ME Jackson, MJ Marino, MM Moran, NA Oberheim, NM Veelen van, NR Swerdlow, NR Swerdlow, NR Swerdlow, NR Swerdlow, O Kranich, P Bezzi, P Steullet, R Bridges, R Gysin, R Janaky, S Bannai, S Bannai, S Bannai, SG Potkin, SuJean Choi, T Majic, V Kumari, V Parpura, Victoria Lutgen, VM Goghari, VP Bakshi, WE Bunney, Y Cho, ZC Ye   +81 more
core   +2 more sources

Proteomic analysis reveals novel binding partners of metabotropic glutamate receptor 1 [PDF]

Journal of Neurochemistry, 2009
AbstractRegulated trafficking of neurotransmitter receptors is critical to normal neurodevelopment and neuronal signaling. Group I mGluRs (mGluR1/5 and their splice variants) are G protein‐coupled receptors enriched at excitatory synapses, where they serve to modulate glutamatergic transmission.
Anna, Francesconi, Ranju, Kumari, R Suzanne, Zukin   +2 more
openaire   +2 more sources

Cooperative Signaling between Homodimers of Metabotropic Glutamate Receptors 1 and 5 [PDF]

Molecular Pharmacology, 2014
Metabotropic glutamate receptors (mGluRs) function as dimers. Recent work suggests that mGluR1 and mGluR5 may physically interact, but the nature and functional consequences of this relationship have not been addressed. In this study, the functional and pharmacological consequences of this interaction were investigated. Using heterologous expression of
Tatyana N, Sevastyanova, Paul J, Kammermeier   +1 more
openaire   +2 more sources