Results 21 to 30 of about 582,384 (267)
GRM1 (glutamate receptor, metabotropic 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014 Review on GRM1, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
Sierra, J, Chen, S
openaire +2 more sources
Group 1 metabotropic glutamate receptors and schizophrenia [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2011 AbstractSchizophrenia is a prevalent neuropsychiatric disorder associated with perturbations in medial prefrontal cortex (PFC) excitability and connectivity. As such, research into the neurobiology of schizophrenia and related psychotic disorders has focused on understanding the possible role played by the major excitatory neurotransmitter glutamate in
DE BARTOLOMEIS, ANDREA, Szumlinski K. K.
openaire +3 more sources
L-Glutamate supplementation improves small intestinal architecture and enhances the expressions of jejunal mucosa amino acid receptors and transporters in weaning piglets. [PDF]
PLoS ONE, 2014 L-Glutamate is a major oxidative fuel for the small intestine. However, few studies have demonstrated the effect of L-glutamate on the intestinal architecture and signaling of amino acids in the small intestine.
Meng Lin +7 more
doaj +1 more source
FMRP mediates mGluR5-dependent translation of amyloid precursor protein. [PDF]
PLoS Biology, 2007 Amyloid precursor protein (APP) facilitates synapse formation in the developing brain, while beta-amyloid (Abeta) accumulation, which is associated with Alzheimer disease, results in synaptic loss and impaired neurotransmission.
Cara J Westmark, James S Malter
doaj +1 more source
Accuracy in readout of glutamate concentrations by neuronal cells [PDF]
The European Physical Journal E, 46(4), 30 (2023), 2023 Glutamate and glycine are important neurotransmitters in the brain. An action potential prop- agating in the terminal of a presynatic neuron causes the release of glutamate and glycine in the synapse by vesicles fusing with the cell membrane, which then activate various receptors on the cell membrane of the post synaptic neuron.
arxiv +1 more source
Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus [PDF]
Molecular Pharmacology, 2016 The delta family of ionotropic glutamate receptors consists of glutamate delta-1 (GluD1) and glutamate delta-2 receptors. We have previously shown that GluD1 knockout mice exhibit features of developmental delay, including impaired spine pruning and switch in the N-methyl-D-aspartate receptor subunit, which are relevant to autism and other ...
Subhash C. Gupta +5 more
openaire +3 more sources
Neural Regeneration Research, 2021 Our previous studies have shown that glutamate and hippocampal neuron apoptosis are key signals and direct factors associated with diabetes-related depression, and structural and functional damage to the hippocampal neurovascular unit has been associated
Jian Liu +7 more
doaj +1 more source
MicroRNA binding site variation is enriched in psychiatric disorders
Human Mutation, Volume 43, Issue 12, Page 2153-2169, December 2022., 2022 Abstract Psychiatric disorders have a polygenic architecture, often associated with dozens or hundreds of independent genomic loci. Most associated loci impact noncoding regions of the genome, suggesting that the majority of disease heritability originates from the disruption of regulatory sequences.
Michael P. Geaghan +2 more
wiley +1 more source
PLoS ONE, 2021 Crustaceans are major constituents of aquatic ecosystems and, as such, changes in their behavior and the structure and function of their bodies can serve as indicators of alterations in their immediate environment, such as those associated with climate ...
Jonathan L Crooke-Rosado +4 more
doaj +1 more source
Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes [PDF]
Kidney International, 2012 In non-neuronal cells, glutamate is an extracellular signaling mediator. Since podocytes have glutamate-containing vesicles, we sought to determine glutamate receptor presence and action in glomerular cells. The metabotropic glutamate receptors (mGluR) 1, 5, 6, and 8 were found to be expressed in mouse brain and glomeruli; predominantly in podocytes ...
Xinyue Liang +11 more
openaire +2 more sources