Results 31 to 40 of about 1,029 (201)

Participation of the Cholinergic System in Ameliorating Effect of Vasopressin Fragment by Group I Metabotropic Glutamate–Receptor Blockade

Journal of Pharmacological Sciences, 2008
The effect of [pGlu4,Cyt6,Arg8]-vasopressin fragment 4-9 (AVP4-9) on group I metabotropic glutamate (mGlu1) receptor antagonist–induced memory deficits was studied using 8-arm radial maze performance with 4 arms baited.
Tadatsugu Tarumi, Azusa Mikami, Kenichi Shimada, Chiaki Kamei   +3 more
doaj   +1 more source

Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice [PDF]

PeerJ, 2015
Spinal astrocyte activation contributes to the pathogenesis of paclitaxel-induced neuropathic pain (PINP) in animal models. We examined glial fibrillary acidic protein (GFAP; an astrocyte marker) immunoreactivity and gene expression of GFAP, glutamate ...
Willias Masocha
doaj   +2 more sources

Metabotropic glutamate receptor subtype-1 is essential for in vivo growth of melanoma [PDF]

Oncogene, 2008
Ectopic expression of metabotropic glutamate receptor subtype 1 (mGluR1) in mouse melanocytes induces melanoma formation. Although requirement of mGluR1 for development of melanoma in the initial stage has been demonstrated, its role in melanoma growth in vivo remains unclear. In this study, we developed novel transgenic mice that conditionally express
Y, Ohtani, T, Harada, Y, Funasaka, K, Nakao, C, Takahara, M, Abdel-Daim, N, Sakai, N, Saito, C, Nishigori, A, Aiba   +9 more
openaire   +2 more sources

Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins

BMC Neuroscience, 2006
Background Metabotropic glutamate receptors (mGluRs) regulate neuronal excitability and synaptic strength. The group I mGluRs, mGluR1 and 5, are widespread in the brain and localize to post-synaptic sites. The Homer protein family regulates group I mGluR
Kammermeier Paul J
doaj   +1 more source

A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors [PDF]

The Journal of Neuroscience, 2018
Group I metabotropic glutamate receptors (mGluRs) function as modulators of neuronal physiology and they have also been implicated in various neuropsychiatric disorders. Trafficking of mGluRs plays important roles in controlling the precise localization of these receptors at specific region of the cell, as well as it regulates the activity of these ...
Rohan, Sharma, Ravinder, Gulia, Samarjit, Bhattacharyya   +2 more
openaire   +2 more sources

Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats

BMC Neuroscience, 2008
Background Many studies have focused on the implication of the serotonin and dopamine systems in neuroadaptive responses to the recreational drug 3,4-methylenedioxy-metamphetamine (MDMA).
Malki Rana, Blomqvist Anna, Kindlundh-Högberg Anna MS, Schiöth Helgi B   +3 more
doaj   +1 more source

The Role of Metabotropic Glutamate Receptor 1 Dependent Signaling in Glioma Viability [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2018
Glioma refers to malignant central nervous system tumors that have histologic characteristics in common with glial cells. The most prevalent type, glioblastoma multiforme, is associated with a poor prognosis and few treatment options. On the basis of reports of aberrant expression of mGluR1 mRNA in glioma, evidence that melanoma growth is directly ...
Carrie Bowman Dalley, Barbara Wroblewska, Barry B. Wolfe, Jarda T. Wroblewski   +3 more
openaire   +2 more sources

Nonheme Fe Enzyme‐Catalyzed Enantiodivergent Nitrogen Migration: Directed Evolution and Computational Study of Isopenicillin N Synthases for Biocatalytic Synthesis of Arylglycines

Angewandte Chemie, EarlyView.
Nonheme Fe enzyme isopenicillin N synthase was reprogrammed and evolved as an efficient nitrogen migratase IPNSNim, converting diverse azanyl esters to valuable l‐arylglycines with up to 16 000 TTN and 97:3 e.r. IPNSNim and ACCONim allowed enantiodivergent preparation of both l‐ and d‐arylglycines.
Ken Lin, Liu‐Peng Zhao, Shengchun Wang, Huichong Liu, Yu Zhang, Binh Khanh Mai, Peng Liu, Yang Yang   +7 more
wiley   +2 more sources

Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes. [PDF]

PLoS ONE, 2013
Several epidemiological studies have suggested a link between melanoma and breast cancer. Metabotropic glutamate receptor 1 (GRM1), which is involved in many cellular processes including proliferation and differentiation, has been implicated in ...
Madhura S Mehta, Sonia C Dolfi, Roman Bronfenbrener, Erhan Bilal, Chunxia Chen, Dirk Moore, Yong Lin, Hussein Rahim, Seena Aisner, Romona D Kersellius, Jessica Teh, Suzie Chen, Deborah L Toppmeyer, Dan J Medina, Shridar Ganesan, Alexei Vazquez, Kim M Hirshfield   +16 more
doaj   +1 more source

Disynaptic Amplification of Metabotropic Glutamate Receptor 1 Responses in the Olfactory Bulb [PDF]

The Journal of Neuroscience, 2007
Sensory systems often respond to rapid stimuli with high frequency and fidelity, as perhaps best exemplified in the auditory system. Fast synaptic responses are fundamental requirements to achieve this task. The importance of speed is less clear in the olfactory system. Moreover, olfactory bulb output mitral cells respond to a single stimulation of the
Didier, De Saint Jan, Gary L, Westbrook
openaire   +2 more sources