Results 31 to 40 of about 56,166 (223)

Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice [PDF]

PeerJ, 2015
Spinal astrocyte activation contributes to the pathogenesis of paclitaxel-induced neuropathic pain (PINP) in animal models. We examined glial fibrillary acidic protein (GFAP; an astrocyte marker) immunoreactivity and gene expression of GFAP, glutamate ...
Willias Masocha
doaj   +2 more sources

Participation of the Cholinergic System in Ameliorating Effect of Vasopressin Fragment by Group I Metabotropic Glutamate–Receptor Blockade

Journal of Pharmacological Sciences, 2008
The effect of [pGlu4,Cyt6,Arg8]-vasopressin fragment 4-9 (AVP4-9) on group I metabotropic glutamate (mGlu1) receptor antagonist–induced memory deficits was studied using 8-arm radial maze performance with 4 arms baited.
Tadatsugu Tarumi, Azusa Mikami, Kenichi Shimada, Chiaki Kamei   +3 more
doaj   +1 more source

Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins

BMC Neuroscience, 2006
Background Metabotropic glutamate receptors (mGluRs) regulate neuronal excitability and synaptic strength. The group I mGluRs, mGluR1 and 5, are widespread in the brain and localize to post-synaptic sites. The Homer protein family regulates group I mGluR
Kammermeier Paul J
doaj   +1 more source

Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats

BMC Neuroscience, 2008
Background Many studies have focused on the implication of the serotonin and dopamine systems in neuroadaptive responses to the recreational drug 3,4-methylenedioxy-metamphetamine (MDMA).
Malki Rana, Blomqvist Anna, Kindlundh-Högberg Anna MS, Schiöth Helgi B   +3 more
doaj   +1 more source

Molecular docking studies of N-substituted 4-methoxy-6-oxo-1-aryl-pyridazine-3-carboxamide derivatives as potential modulators of glutamate receptors [PDF]

Research Results in Pharmacology, 2020
Introduction: The virtual target-oriented screening is a necessary stage of modern drug-design. In the present study, the affinity of pyridazine derivatives for the most promising antiparkinsonian biotargets – I–III groups of metabotropic and ionotropic ...
Hanna I. Severina, Victoriya A. Georgiyants, Sergiy M. Kovalenko, Natalia V. Avdeeva, Artem I. Yarcev, Svetlana N. Prohoda   +5 more
doaj   +3 more sources

Metabotropic Glutamate Receptor 1 acts as a Dependence Receptor Creating a Requirement for Glutamate to Sustain the Viability and Growth of Human Melanomas

Oncogene, 2014
Metabotropic glutamate 1 (mGlu) receptor has been proposed as a target for the treatment of metastatic melanoma. Studies have demonstrated that inhibiting the release of glutamate (the natural ligand of mGlu1 receptors), results in a decrease of melanoma
T. Gelb, S. Pshenichkin, Olga C. Rodriguez, Hannah A Hathaway, E. Grajkowska, John O. DiRaddo, B. Wróblewska, R. Yasuda, C. Albanese, B. Wolfe, J. Wroblewski   +10 more
semanticscholar   +1 more source

Ionotropic glutamate receptors and their implications in cancer and cancer therapeutics

Biomedical and Biotechnology Research Journal, 2021
Glutamine, an excitatory neurotransmitter, is necessary for physiological as well as pathological processes. Other than neuronal disorders and/or cancers, glutamate receptors have also been associated with an array of other malignancies. The metabotropic
Shree Goyal, Pallab Chakraborty, Balasubramaniam Shankar   +2 more
doaj   +1 more source

Cerebellar encephalitis associated with anti-mGluR1 antibodies: a case report and comprehensive literature review

Frontiers in Neurology
Anti-metabotropic glutamate receptor 1 encephalitis is an uncommon autoimmune condition characterized by a subacute onset of cerebellar syndrome. Frequently, it also manifests as sleep disorders and cognitive or behavioral changes. While immunotherapy is
Xue Chen, Yanan Chen, Lu Di, Na Liu, Ting Liu, Yun Cai, Weiying Di   +6 more
doaj   +1 more source

Implication of neuronal Ca2+-sensor protein VILIP-1 in the glutamate hypothesis of schizophrenia

Neurobiology of Disease, 2008
Post mortem studies in the hippocampus of schizophrenia patients revealed increased expression of neuronal Ca2+-sensor VILIP-1 (visinin-like protein) and enhanced co-localization with α4β2 nAChR in interneurons. To study the pathological role of VILIP-1,
Paul Gierke, CongJian Zhao, Hans-Gert Bernstein, Cornelia Noack, Rene Anand, Uwe Heinemann, Karl-Heinz Braunewell   +6 more
doaj   +1 more source

Disynaptic Amplification of Metabotropic Glutamate Receptor 1 Responses in the Olfactory Bulb

Journal of Neuroscience, 2007
Sensory systems often respond to rapid stimuli with high frequency and fidelity, as perhaps best exemplified in the auditory system. Fast synaptic responses are fundamental requirements to achieve this task.
D. De Saint Jan, G. Westbrook
semanticscholar   +1 more source