Results 41 to 50 of about 1,029 (201)

Molecular docking studies of N-substituted 4-methoxy-6-oxo-1-aryl-pyridazine-3-carboxamide derivatives as potential modulators of glutamate receptors [PDF]

Research Results in Pharmacology, 2020
Introduction: The virtual target-oriented screening is a necessary stage of modern drug-design. In the present study, the affinity of pyridazine derivatives for the most promising antiparkinsonian biotargets – I–III groups of metabotropic and ionotropic ...
Hanna I. Severina, Victoriya A. Georgiyants, Sergiy M. Kovalenko, Natalia V. Avdeeva, Artem I. Yarcev, Svetlana N. Prohoda   +5 more
doaj   +3 more sources

Cerebellar encephalitis associated with anti-mGluR1 antibodies: a case report and comprehensive literature review

Frontiers in Neurology
Anti-metabotropic glutamate receptor 1 encephalitis is an uncommon autoimmune condition characterized by a subacute onset of cerebellar syndrome. Frequently, it also manifests as sleep disorders and cognitive or behavioral changes. While immunotherapy is
Xue Chen, Yanan Chen, Lu Di, Na Liu, Ting Liu, Yun Cai, Weiying Di   +6 more
doaj   +1 more source

Ionotropic glutamate receptors and their implications in cancer and cancer therapeutics

Biomedical and Biotechnology Research Journal, 2021
Glutamine, an excitatory neurotransmitter, is necessary for physiological as well as pathological processes. Other than neuronal disorders and/or cancers, glutamate receptors have also been associated with an array of other malignancies. The metabotropic
Shree Goyal, Pallab Chakraborty, Balasubramaniam Shankar   +2 more
doaj   +1 more source

Implication of neuronal Ca2+-sensor protein VILIP-1 in the glutamate hypothesis of schizophrenia

Neurobiology of Disease, 2008
Post mortem studies in the hippocampus of schizophrenia patients revealed increased expression of neuronal Ca2+-sensor VILIP-1 (visinin-like protein) and enhanced co-localization with α4β2 nAChR in interneurons. To study the pathological role of VILIP-1,
Paul Gierke, CongJian Zhao, Hans-Gert Bernstein, Cornelia Noack, Rene Anand, Uwe Heinemann, Karl-Heinz Braunewell   +6 more
doaj   +1 more source

Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation [PDF]

Pigment Cell & Melanoma Research, 2008
SummaryPreviously, we reported a transgenic mouse line, TG‐3, that develops spontaneous melanoma with 100% penetrance. We demonstrated that ectopic expression of Grm1 in melanocytes was sufficient to induce melanoma in vivo. In this present study, the transforming properties of Grm1 in two cultured immortalized melanocytes were investigated.
Seung-Shick, Shin, Jin, Namkoong, Brian A, Wall, Ryan, Gleason, Hwa Jin, Lee, Suzie, Chen   +5 more
openaire   +2 more sources

Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes [PDF]

Kidney International, 2012
In non-neuronal cells, glutamate is an extracellular signaling mediator. Since podocytes have glutamate-containing vesicles, we sought to determine glutamate receptor presence and action in glomerular cells. The metabotropic glutamate receptors (mGluR) 1, 5, 6, and 8 were found to be expressed in mouse brain and glomeruli; predominantly in podocytes ...
Gu, Leyi, Liang, Xinyue, Wang, Lihua, Yan, Yucheng, Ni, Zhaohui, Dai, Huili, Gao, Jiayuan, Mou, Shan, Wang, Qin, Chen, Xinyu, Wang, Liming, Qian, Jiaqi   +11 more
openaire   +2 more sources

Cooperative Signaling between Homodimers of Metabotropic Glutamate Receptors 1 and 5 [PDF]

Molecular Pharmacology, 2014
Metabotropic glutamate receptors (mGluRs) function as dimers. Recent work suggests that mGluR1 and mGluR5 may physically interact, but the nature and functional consequences of this relationship have not been addressed. In this study, the functional and pharmacological consequences of this interaction were investigated. Using heterologous expression of
Tatyana N, Sevastyanova, Paul J, Kammermeier   +1 more
openaire   +2 more sources

Near‐Infrared Organic Photovoltaic Electrodes for Subretinal Neurostimulation

Advanced Functional Materials, EarlyView.
Organic photovoltaic electrodes based on the D18:Y6 blend enable precise and light‐controlled activation of retinal ganglion cells in a degenerating retina. NIR Light‐driven activation of retinal ganglion cells, tunable stimulation parameters, and biocompatibility with human retinal organoids highlight their potential for next‐generation prosthetics ...
Andrea Corna, Katarina Gugujonovic, Manuela Schiek, Alessandro Bellapianta, Paul Werginz, Amelie Ziller, Markus Clark Scharber, Ahmad Salti, Matthias Bolz, Mihai Irimia‐Vladu, Günther Zeck   +10 more
wiley   +1 more source

Complex formation and functional interaction between adenosine A1 receptor and type-1 metabotropic glutamate receptor

Journal of Pharmacological Sciences, 2015
The adenosine A1 receptor (A1R) is a G protein-coupled receptor (GPCR) for adenosine, a ubiquitous neuromodulator, and thus regulates neuronal excitability, as well as arousal and sensitivity to pain.
Yuji Kamikubo, Toshihide Tabata, Hakushun Sakairi, Yoshie Hashimoto, Takashi Sakurai   +4 more
doaj   +1 more source

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source