Results 41 to 50 of about 582,384 (267)
Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice [PDF]
PeerJ, 2015 Spinal astrocyte activation contributes to the pathogenesis of paclitaxel-induced neuropathic pain (PINP) in animal models. We examined glial fibrillary acidic protein (GFAP; an astrocyte marker) immunoreactivity and gene expression of GFAP, glutamate ...
Willias Masocha
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The Role of Metabotropic Glutamate Receptor 1 Dependent Signaling in Glioma Viability [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2018 Glioma refers to malignant central nervous system tumors that have histologic characteristics in common with glial cells. The most prevalent type, glioblastoma multiforme, is associated with a poor prognosis and few treatment options. On the basis of reports of aberrant expression of mGluR1 mRNA in glioma, evidence that melanoma growth is directly ...
Carrie Bowman Dalley +3 more
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ASN Neuro, 2009 A number of studies suggest that OLGs (oligodendrocytes), the myelinating cells of the central nervous system, are also a source of trophic molecules, such as neurotrophins that may influence survival of proximate neurons.
Issa P Bagayogo, Cheryl F Dreyfus
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Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons. [PDF]
PLoS ONE, 2009 Metabotropic glutamate (mGlu) receptors have been considered potential targets for the therapy of experimental parkinsonism. One hypothetical advantage associated with the use of mGlu receptor ligands is the lack of the adverse effects typically induced ...
Giuseppe Battaglia +13 more
doaj +1 more source
Disynaptic Amplification of Metabotropic Glutamate Receptor 1 Responses in the Olfactory Bulb [PDF]
The Journal of Neuroscience, 2007 Sensory systems often respond to rapid stimuli with high frequency and fidelity, as perhaps best exemplified in the auditory system. Fast synaptic responses are fundamental requirements to achieve this task. The importance of speed is less clear in the olfactory system. Moreover, olfactory bulb output mitral cells respond to a single stimulation of the
Gary L. Westbrook +2 more
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Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait [PDF]
Current Biology, 2021 Sufficient and efficient sleep is crucial for our health. Natural short sleepers can sleep significantly shorter than the average population without a desire for more sleep and without any obvious negative health consequences. In searching for genetic variants underlying the short sleep trait, we found two different mutations in the same gene ...
Guangsen Shi +9 more
openaire +4 more sources
European Journal of Neuroscience, Volume 56, Issue 12, Page 6141-6161, December 2022., 2022 Chemical synapses are tiny and overcrowded environments enriched with thousands of protein species. Many efforts have been devoted to developing sensors and actuators able to evaluate and control synaptic communication. Most of these recent tools are based on the engineering of one or more specific synaptic proteins used to target active moieties to ...
Jacopo Lamanna +3 more
wiley +1 more source
BMC Neuroscience, 2008 Background Many studies have focused on the implication of the serotonin and dopamine systems in neuroadaptive responses to the recreational drug 3,4-methylenedioxy-metamphetamine (MDMA).
Malki Rana +3 more
doaj +1 more source
Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes. [PDF]
PLoS ONE, 2013 Several epidemiological studies have suggested a link between melanoma and breast cancer. Metabotropic glutamate receptor 1 (GRM1), which is involved in many cellular processes including proliferation and differentiation, has been implicated in ...
Madhura S Mehta +16 more
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Modeling T1 Resting-State MRI Variants Using Convolutional Neural Networks in Diagnosis of OCD [PDF]
arXiv, 2023 Obsessive-compulsive disorder (OCD) presents itself as a highly debilitating disorder. The disorder has common associations with the prefrontal cortex and the glutamate receptor known as Metabotropic Glutamate Receptor 5 (mGluR5). This receptor has been observed to demonstrate higher levels of signaling from positron emission tomography scans measured ...
arxiv