Results 51 to 60 of about 56,166 (223)

Glutamate Receptor δ2 Associates with Metabotropic Glutamate Receptor 1 (mGluR1), Protein Kinase Cγ, and Canonical Transient Receptor Potential 3 and Regulates mGluR1-Mediated Synaptic Transmission in Cerebellar Purkinje Neurons

Journal of Neuroscience, 2012
Cerebellar motor coordination and cerebellar Purkinje cell synaptic function require metabotropic glutamate receptor 1 (mGluR1, Grm1). We used an unbiased proteomic approach to identify protein partners for mGluR1 in cerebellum and discovered glutamate ...
Akihiko S. Kato, M. Knierman, E. Siuda, J. Isaac, E. Nisenbaum, D. Bredt   +5 more
semanticscholar   +1 more source

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

Annals of Neurology, EarlyView.
Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and disease.
Nico J. Diederich, Martin Brüne, John S. Allen, Nicole Bender, Emiliano Bruner, Jean‐Pierre Changeux, Corrado Cali, Olga Dolgova, Anne Grünewald, Geneviève Konopka, Peng Jin, Roger Lemon, Gilberto Levy, Pierre Magistretti, Markus J. Rantala, Kathleen S. Rockland, Roger Sullivan, Annie Swanepoel, Toshiki Uchihara, Katrin Amunts, Christopher G. Goetz   +20 more
wiley   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Discovery of Orally Efficacious Tetracyclic Metabotropic Glutamate Receptor 1 (mGluR1) Antagonists for the Treatment of Chronic Pain

Journal of Medicinal Chemistry, 2007
Wen‐Lian Wu, Duane A. Burnett, Martin S. Domalski, William J. Greenlee, Cheng Li, Rosalia Bertorelli, Silva Fredduzzi, Gianluca Lozza, Alessio Veltri, Angelo Reggiani   +9 more
openalex   +2 more sources

Soluble Ectodomain of Neuroligin 1 Decreases Synaptic Activity by Activating Metabotropic Glutamate Receptor 2

Frontiers in Molecular Neuroscience, 2017
Synaptic cell adhesion molecules represent important targets for neuronal activity-dependent proteolysis. Postsynaptic neuroligins (NLs) form trans-synaptic complexes with presynaptic neurexins (NXs). Both NXs and NLs are cleaved from the cell surface by
Michelle D. Gjørlund, Michelle D. Gjørlund, Eva M. M. Carlsen, Andreas B. Kønig, Oksana Dmytrieva, Anders V. Petersen, Jacob Jacobsen, Vladimir Berezin, Jean-François Perrier, Sylwia Owczarek   +9 more
doaj   +1 more source

Metabotropic Glutamate Receptor 1 Mediates the Electrophysiological and Toxic Actions of the Cycad Derivative β-N-Methylamino-l-Alanine on Substantia Nigra Pars Compacta DAergic Neurons

Journal of Neuroscience, 2010
Amyotrophic lateral sclerosis–Parkinson dementia complex (ALS-PDC) is a neurodegenerative disease with ALS, parkinsonism, and Alzheimer's symptoms that is prevalent in the Guam population.
M. L. Cucchiaroni, M. T. Viscomi, G. Bernardi, M. Molinari, E. Guatteo, N. Mercuri   +5 more
semanticscholar   +1 more source

Seizures beget more than seizures: Understanding the cellular, structural, individual and societal impact of seizures in epilepsy

Epilepsia Open, EarlyView.
Abstract Epilepsy is primarily defined by the repetitive occurrence of seizures, but the full impact of seizures extends beyond these episodic events. Seizures themselves cause changes at the cellular, network, and systemic levels in individual patients with epilepsy and may contribute to the progressive nature of the disease in some patients. Seizures
Matthew C. Walker, Marian Galovic, Elena Álvarez‐Barón, Adam Strzelczyk   +3 more
wiley   +1 more source

Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps

Journal of Applied Toxicology, EarlyView.
ABSTRACT Despite growing health concerns, bifenthrin (BF) remains widely used for controlling agricultural and residential pests. However, different perspectives on its toxicological profile and regulatory framework warrant a revisit and update on BF regulation towards a robust risk‐safety assessment.
Caroline V. L. Moreira, John Ogbu I, Kadja L. C. Monteiro, Thiago M. de Aquino, Edeildo F. da Silva‐Júnior, Alberto S. S. Filho, Hamilton B. Napolitano, Christianah A. Elusiyan, Renê O. do Couto, Elson A. Costa, James O. Fajemiroye   +10 more
wiley   +1 more source

Human Neuroepithelial Cells Express NMDA Receptors

BMC Neuroscience, 2003
L-glutamate, an excitatory neurotransmitter, binds to both ionotropic and metabotropic glutamate receptors. In certain parts of the brain the BBB contains two normally impermeable barriers: 1) cerebral endothelial barrier and 2) cerebral epithelial ...
Cappell B, Chandler I, Nanda A, Warren A, Houghton J, Jackson TH, Fowler M, Sharp Christopher D, Long A, Minagar A, Alexander JS   +10 more
doaj   +1 more source

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, EarlyView.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source