Results 61 to 70 of about 1,029 (201)

Soluble Ectodomain of Neuroligin 1 Decreases Synaptic Activity by Activating Metabotropic Glutamate Receptor 2

Frontiers in Molecular Neuroscience, 2017
Synaptic cell adhesion molecules represent important targets for neuronal activity-dependent proteolysis. Postsynaptic neuroligins (NLs) form trans-synaptic complexes with presynaptic neurexins (NXs). Both NXs and NLs are cleaved from the cell surface by
Michelle D. Gjørlund, Michelle D. Gjørlund, Eva M. M. Carlsen, Andreas B. Kønig, Oksana Dmytrieva, Anders V. Petersen, Jacob Jacobsen, Vladimir Berezin, Jean-François Perrier, Sylwia Owczarek   +9 more
doaj   +1 more source

White Matter Dysfunction and Neurotransmitter Basis Underlying the Freezing of Gait in Parkinson's Disease

iNew Medicine, EarlyView.
In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu, Jinmei Sun, Lili Hu, Xin Chen, Jinying Han, Liuzhenxiong Yu, Siyu Fan, Rong Ye, Kai Wang, Gong‐Jun Ji, Panpan Hu   +10 more
wiley   +1 more source

Human Neuroepithelial Cells Express NMDA Receptors

BMC Neuroscience, 2003
L-glutamate, an excitatory neurotransmitter, binds to both ionotropic and metabotropic glutamate receptors. In certain parts of the brain the BBB contains two normally impermeable barriers: 1) cerebral endothelial barrier and 2) cerebral epithelial ...
Cappell B, Chandler I, Nanda A, Warren A, Houghton J, Jackson TH, Fowler M, Sharp Christopher D, Long A, Minagar A, Alexander JS   +10 more
doaj   +1 more source

The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy

Pediatric Investigation, EarlyView.
The ketogenic diet alleviates West syndrome by reshaping gut microbiota (increasing Bacteroides, Parabacteroides, and reducing Escherichia and Bifidobacterium), and modulating metabolites—including anticonvulsant lipids (e.g., capric acid), suppressed harmful lipids (e.g., 2‐methylbutyroylcarnitine), and amino acids and analogs (e.g., 3‐sulfinoalanine)—
Gan Xie, Qian Zhou, Jianxiang Liao, Yuejie Zheng, Wenjian Wang, Kunling Shen   +5 more
wiley   +1 more source

Can Metabotropic Glutamate Receptor 7 (mGluR 7) be a Novel Target for Analgesia? [PDF]

Journal of Clinical and Diagnostic Research, 2014
Introduction: The present study was carried out to study the role of metabotropic glutamate receptor 7 (mGluR7) using its agonist, N,N’-bis(diphenylmethyl)-1,-ethanediamine (AMN082) for nociceptive stimuli, in animal models.
Shivaprakash G, Punya Suvarna, Sanjay Hadigal, Priyanka Kamath, Natesh Prabhu, Ashok Shenoy K, Pallavi LC   +6 more
doaj   +1 more source

Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation

Small Science, EarlyView.
Tregs control immune tolerance but can also enable tumor escape. Nanomaterials can now expand or stabilize Tregs to treat autoimmunity and support transplantation or conversely disrupt tumor Tregs to boost antitumor immunity. We also discuss unintended Treg modulation by nanoparticles, safety and manufacturing challenges, and future translational ...
Yiyin Chen, Haibo Huang, Xiang Wang, Xinghao Yu, Ziyan Huang, Zhou Jin, Chen Chen, Yan Chen, Bruce R. Blazar, Yang Xu, Yunjie Lu   +10 more
wiley   +1 more source

AMPK acts as a molecular trigger to coordinate glutamatergic signals and adaptive behaviours during acute starvation

eLife, 2016
The stress associated with starvation is accompanied by compensatory behaviours that enhance foraging efficiency and increase the probability of encountering food.
Moloud Ahmadi, Richard Roy
doaj   +1 more source

Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer. [PDF]

PLoS ONE, 2014
Metabotropic glutamate receptors (mGluRs) are normally expressed in the central nervous system, where they mediate neuronal excitability and neurotransmitter release.
Cecilia L Speyer, Ali H Hachem, Ali A Assi, Jennifer S Johnson, John A DeVries, David H Gorski   +5 more
doaj   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives

Molecules, 2015
A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone.
Youngjae Kim, Minjoo Kim, Mooseong Park, Jinsung Tae, Du-Jong Baek, Ki Duk Park, Hyunah Choo   +6 more
doaj   +1 more source