Results 61 to 70 of about 56,166 (223)
Can Metabotropic Glutamate Receptor 7 (mGluR 7) be a Novel Target for Analgesia? [PDF]
Journal of Clinical and Diagnostic Research, 2014 Introduction: The present study was carried out to study the role of metabotropic glutamate receptor 7 (mGluR7) using its agonist, N,N’-bis(diphenylmethyl)-1,-ethanediamine (AMN082) for nociceptive stimuli, in animal models.
Shivaprakash G +6 more
doaj +1 more source
Cys-140 Is Critical for Metabotropic Glutamate Receptor-1 Dimerization*
Journal of Biological Chemistry, 2000 Metabotropic glutamate receptor 1 (mGluR1) expresses at the cell surface as disulfide-linked dimers and can be reduced to monomers with sulfhydryl reagents.
Kausik Ray, B. Hauschild
semanticscholar +1 more source
eLife, 2016 The stress associated with starvation is accompanied by compensatory behaviours that enhance foraging efficiency and increase the probability of encountering food.
Moloud Ahmadi, Richard Roy
doaj +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan +6 more
wiley +1 more source
Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives
Molecules, 2015 A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone.
Youngjae Kim +6 more
doaj +1 more source
First evidence for the presence of amino acid sensing mechanisms in the fish gastrointestinal tract
Scientific Reports, 2021 This study aimed to characterize amino acid sensing systems in the gastrointestinal tract (GIT) of the carnivorous fish model species rainbow trout. We observed that the trout GIT expresses mRNAs encoding some amino acid receptors described in mammals ...
Jessica Calo +5 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller +3 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2014 Neuronal activity results in long lasting changes in synaptic structure and function by regulating mRNA translation in dendrites. These activity dependent events yield the synthesis of proteins known to be important for synaptic modifications and diverse
Christopher eHeise +6 more
doaj +1 more source
Journal of Diabetes, 2023 Background Glutamate is a major neurotransmitter, although it causes cytotoxicity and inflammation in nonneuronal organs. This study aimed to investigate the metabolic disorders in which glutamate, associated with type 2 diabetes onset, is induced in the
Hyo Jung Lee +7 more
doaj +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source