Results 81 to 90 of about 54,745 (192)

N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans. [PDF]

, 2015
Emerging research seeking novel analgesic drugs focuses on agents targeting group-II metabotropic glutamate receptors (mGlu2 and mGlu3 receptors). N-Acetylcysteine (NAC) enhances the endogenous activation of mGlu2/3 receptors by activating the glial ...
BATTAGLIA, Giuseppe, CRUCCU, Giorgio, DI STEFANO, GIULIA, E. Pasquale, LATTANZI, Roberta, NICOLETTI, Ferdinando, PIROSO, SERENA, S. Notartomaso, TRUINI, ANDREA   +8 more
core   +1 more source

Effect of novel metabotropic glutamate receptor 5 antagonist on gastroesophageal reflux in dogs during anaesthesia

Journal of Small Animal Practice, EarlyView.
Objectives Gastroesophageal reflux during anaesthesia is a common event occurring in dogs with the potential to cause oesophageal injury and aspiration pneumonia. The objective of the current study was to evaluate the effect of the novel metabotropic glutamate receptor 5 antagonist TT001 on gastroesophageal reflux during anaesthesia in dogs using two ...
A. Glovéus, C. Ekstrand, A. Flöhr, S. Viskjer, O. Höglund   +4 more
wiley   +1 more source

Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings [PDF]

, 2016
Herein, we have reviewed the role of glutamate, the major excitatory neurotransmitter in the brain, in a number of neurochemical, -physiological, and -behavioral processes mediating the development of alcohol dependence.
Aal-Aaboda, Abe, Abulseoud, Ady, Agrawal, Alasmari, Alhaddad, Arriza, Babu, Bard, Bauer, Beattie, Begleiter, Bell, Bell, Bell, Bell, Bell, Bell, Besheer, Besheer, Besheer, Bischoff, Bockaert, Bondy, Bäckström, Béïque, Cannady, Cannella, Carlezon, Chandler, Chandler, Chefer, Chen, Chen, Cicero, Cloninger, Cohen-Gilbert, Comasco, Cotton, Cowen, Cozzoli, Cozzoli, Cozzoli, Crabbe, Danbolt, Das, Ding, Ding, Domart, Edenberg, Edenberg, Ehlers, El-Husseini, Ende, Enoch, Falco, Flatscher-Bader, Floyd, Fotuhi, Funke, Garbett, Garner, Gass, Gass, Goodwani, Gould, Goulding, Grace, Griffin, Hargreaves, Harris, Henley, Hermann, Hermens, Hodge, Isaac, Jaffrey, Jani, Jin, Joslyn, Kalivas, Kapasova, Kapoor, Karkkainen, Karpyak, Kimpel, Klugmann, Kohda, Konno, Koob, Kornau, Kranzler, Kryger, Krystal, Kuo, Kupila, Lallemand, Lappalainen, Laukkainen, Lester, Levey, Lin, Lin, Loh, Lominac, Long, Lum, Lüscher, Maday, Malenka, Malinow, Mardones, Matsumoto, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McClintick, McCool, Meinhardt, Melendez, Mokdad, Monaghan, Morris, Nevo, Niciu, Obara, Olive, Orth, O’Connor, O’Connor, Patten, Petrakis, Petralia, Preuss, Qrunfleh, Quintero, Rani, Rao, Rao, Reed, Rehm, Rehm, Reich, Reimers, Reissner, Richter, Rietschel, Risher, Rodd, Rodd, Romano, Rothstein, Sala, Sari, Sari, Sari, Sari, Sari, Schnell, Schroeder, Schroeder, Schuckit, Schumann, Selim, Shaw, Sheng, Shigemoto, Shiraishi-Yamaguchi, Spanagel, Staples, Steketee, Swartzwelder, Swartzwelder, Swerdlow, Szumlinski, Szumlinski, Szumlinski, Szumlinski, Tamaru, Tanaka, Tao-Cheng, Tarazi, Terranova, Thoma, Tomita, Traynelis, Van Bockstaele, Vengeliene, Wadiche, Wang, Warburton, Ward, Watterson, Williams, Witzmann, Wong, Worley, Xia, Xiao, Yan, Zamora-Martinez, Zhao, Zhou, Zhou, Ziff   +212 more
core   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

An expanding range of targets for kynurenine metabolites of tryptophan [PDF]

, 2013
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail, Stone, Trevor W., Stoy, Nicholas   +2 more
core   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Metabotropic glutamate receptor 1 alpha: a unique receptor variant with variable implications for Alzheimer's disease pathogenesis. [PDF]

Neural Regen Res, 2023
Yeung JH, Kwakowsky A.
europepmc   +1 more source

Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis

The Journal of Physiology, EarlyView.
Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley   +1 more source

Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats. [PDF]

Cell Mol Neurobiol, 2023
Bai T, Chen H, Hu W, Liu J, Lin X, Chen S, Luo F, Yang X, Chen J, Li C.   +9 more
europepmc   +1 more source

On the hierarchical classification of G Protein-Coupled Receptors [PDF]

, 2007
Motivation: G protein-coupled receptors (GPCRs) play an important role in many physiological systems by transducing an extracellular signal into an intracellular response. Over 50% of all marketed drugs are targeted towards a GPCR.
A. A. Freitas, A. Secker, Attwood, Bhasin, Bhasin, Bissantz, Cardoso, Christopoulos, D. R. Flower, Das, Davies, Flower, Flower, Foord, Gether, Gloriam, Guo, Horn, H  bert, J. Timmis, Karchin, Keerthi, Klabunde, Kolakowski, Lapinsh, M. Mendao, M. N. Davies, Milligan, Papasaikas, Prabhu, Sandberg, Schi  th   +31 more
core   +2 more sources