Results 131 to 140 of about 52,301 (266)
Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu +6 more
wiley +1 more source
Plasticity of GABA(B) receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus [PDF]
Several neurotransmitters, including GABA acting at presynaptic GABAB receptors, modulate glutamate release at synapses between hippocampal mossy fibers and CA3 pyramidal neurons.
Bowery, N.G. +5 more
core
Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses [PDF]
Heteromeric kainate receptors (KARs) containing both glutamate receptor 6 (GluR6) and KA2 subunits are involved in KAR-mediated EPSCs at mossy fiber synapses in CA3 pyramidal cells.
Coussen, F +4 more
core
ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando +7 more
wiley +1 more source
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj +7 more
wiley +1 more source
Recent studies have implicated glutamate neurotransmission as an important substrate for the extinction of conditioned behaviors, including responding for drug reinforcement.
Peter R Kufahl +8 more
doaj +1 more source
Broad spectrum proteomics analysis of the inferior colliculus following acute hydrogen sulfide exposure. [PDF]
Acute exposure to high concentrations of H2S causes severe brain injury and long-term neurological disorders, but the mechanisms involved are not known.
Anantharam, Poojya +8 more
core
Glutamate Delta 1 Receptor in Synapses, Circuits, and Disease
This review discusses our current understanding of the structure–function, expression and roles in neural circuits of the less studied glutamate delta 1 (GluD1) receptor. Converging data suggests many unique features of GluD1 including expression at both excitatory and inhibitory synapses and binding to D‐serine and GABA.
Diane Choi +3 more
wiley +1 more source
We employed a structural bioinformatics approach to develop novel peptides with predicted affinity to the binding site for negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluR5).
Anton V. Malyshev +8 more
doaj +1 more source
Endocannabinoid signaling modulates neurons of the pedunculopontine nucleus (PPN) via astrocytes. [PDF]
The pedunculopontine nucleus (PPN) is known as the cholinergic part of the reticular activating system (RAS) and it plays an important role in transitions of slow-wave sleep to REM sleep and wakefulness.
Antal, Miklós +7 more
core

