Results 141 to 150 of about 52,301 (266)

Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats

, 2009
Norio Yamamoto, Jean‐Jacques Soghomonian   +1 more
openalex   +1 more source

Synthesis and Evaluation in Monkey of [¹⁸F]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([¹⁸F]FIMX): A Promising Radioligand for PET Imaging of Brain Metabotropic Glutamate Receptor 1 (mGluR1)

, 2013
Rong Xu, Paolo Zanotti‐Fregonara, Sami S. Zoghbi, Robert L. Gladding, Alicia E. Woock, Robert B. Innis, Victor W. Pike   +6 more
openalex   +2 more sources

The Metabotropic Glutamate Receptor Subtype 5 Antagonist Fenobam Is Analgesic and Has Improved in Vivo Selectivity Compared with the Prototypical Antagonist 2-Methyl-6-(phenylethynyl)-pyridine [PDF]

, 2009
Michael C. Montana, Laura F. Cavallone, Kristi K. Stubbert, Andrei D. Stefanescu, Evan D. Kharasch, Robert W. Gereau   +5 more
openalex   +1 more source

Development of N-[4-[6-(Isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[¹¹C]methylbenzamide for Positron Emission Tomography Imaging of Metabotropic Glutamate 1 Receptor in Monkey Brain

, 2012
Masayuki Fujinaga, Tomoteru Yamasaki, Jun Maeda, Joji Yui, Lin Xie, Yuji Nagai, Nobuki Nengaki, Akiko Hatori, Katsushi Kumata, Kazunori Kawamura, Ming‐Rong Zhang   +10 more
openalex   +1 more source

Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: A novel approach for controlling status epilepticus

, 2007
Feng Ru Tang, Peng Min Chen, Yong Tang, Mui Chiung Tsai, Wei Ling Lee   +4 more
openalex   +2 more sources

Synthesis, in Vitro Pharmacology, Structure−Activity Relationships, and Pharmacokinetics of 3-Alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent and Selective Group II Metabotropic Glutamate Receptor Antagonists

, 2004
Atsuro Nakazato, Kazunari Sakagami, Akito Yasuhara, Hiroshi Ohta, Ryoko Yoshikawa, Manabu Itoh, Masato Nakamura, Shigeyuki Chaki   +7 more
openalex   +1 more source

Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates

, 2017
Antonia F. Stepan, Michelle M. Claffey, Matthew R. Reese, Gayatri Balan, Gabriela Barreiro, Jason Barricklow, Michael J. Bohanon, Brian P. Boscoe, Gregg D. Cappon, Lois K. Chenard, Julie Cianfrogna, Laigao Chen, Karen J. Coffman, Susan E. Drozda, Joshua R. Dunetz, Somraj Ghosh, Xinjun Hou, Christopher Houle, Kapil Karki, John T. Lazzaro, Jessica Mancuso, John Marcek, Emily Miller, Mark A. Moen, Steven V. O’Neil, Isao Sakurada, Marc B. Skaddan, Vinod D. Parikh, Deborah L. Smith, Patrick Trapa, Jamison B. Tuttle, Patrick R. Verhoest, Daniel P. Walker, Annie Won, Ann S. Wright, Jessica Whritenour, Kenneth Zasadny, Margaret M. Zaleska, Lei Zhang, Christopher L. Shaffer   +39 more
openalex   +1 more source

Neurotransmitter signaling in white matter [PDF]

, 2014
Butt, Arthur M., Fern, Robert F., Matute, Carlos   +2 more
core   +1 more source

Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6-((1H-Pyrazolo[4,3-b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu₄)

, 2018
Sean R. Bollinger, Darren W. Engers, Joseph D. Panarese, Mary G. West, Julie L. Engers, Matthew T. Loch, Alice L. Rodriguez, Anna L. Blobaum, Carrie K. Jones, Analisa Thompson Gray, P. Jeffrey Conn, Craig W. Lindsley, Colleen M. Niswender, Corey R. Hopkins   +13 more
openalex   +1 more source

The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors

, 2000
Adriana Pagano, Doris Rüegg, Stephane Litschig, Natacha Stoehr, Christine Stierlin, Micheline Heinrich, Philipp Floersheim, Laurent Prézeau, Fiona Y. Carroll, Jean‐Philippe Pin, Antonio Cambria, Ivo Vranesic, Peter J. Flor, F. Gasparini, Rainer Kühn   +14 more
openalex   +1 more source