Corrigendum: Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders [PDF]
Frontiers in Molecular Neuroscience, 2018 [This corrects the article DOI: 10.3389/fnmol.2018.00387.].
Nicole M. Fisher +5 more
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Can Metabotropic Glutamate Receptor 7 (mGluR 7) be a Novel Target for Analgesia? [PDF]
Journal of Clinical and Diagnostic Research, 2014 Introduction: The present study was carried out to study the role of metabotropic glutamate receptor 7 (mGluR7) using its agonist, N,N’-bis(diphenylmethyl)-1,-ethanediamine (AMN082) for nociceptive stimuli, in animal models.
Shivaprakash G +6 more
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Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders [PDF]
Frontiers in Molecular Neuroscience, 2018 Neurodevelopmental disorders (NDDs) are characterized by a wide range of symptoms including delayed speech, intellectual disability, motor dysfunction, social deficits, breathing problems, structural abnormalities, and epilepsy.
Nicole M. Fisher +5 more
doaj +7 more sources
Constitutive activity of metabotropic glutamate receptor 7. [PDF]
BMC Neurosci, 2015 BackgroundMetabotropic glutamate receptors (mGluRs) are class C G protein coupled receptors with widespread central nervous system expression. mGluR7 is a member of this family that has been implicated in numerous physiological and pathological processes,
Kammermeier PJ.
europepmc +9 more sources
Activating metabotropic glutamate receptor‑7 attenuates visceral hypersensitivity in neonatal maternally separated rats. [PDF]
Int J Mol Med, 2019 Increasing evidence has indicated that metabotropic glutamate receptor-7 (mGluR7) is an important target for reducing anxiety and stress-associated behaviours.
Shao L +5 more
europepmc +7 more sources
A large consanguineous family with a homozygous Metabotropic Glutamate Receptor 7 (mGlu7) variant and developmental epileptic encephalopathy: Effect on protein structure and ligand affinity [PDF]
Orphanet Journal of Rare Diseases, 2021 Background Developmental and epileptic encephalopathies (DEE) are chronic neurological conditions where epileptic activity contributes to the progressive disruption of brain function, frequently leading to impaired motor, cognitive and sensory ...
Marwa Ben Jdila +6 more
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Metabotropic Glutamate Receptor 7: From Synaptic Function to Therapeutic Implications. [PDF]
Curr Neuropharmacol, 2016 Metabotropic glutamate receptor 7 (mGluR7) is localized presynaptically at the active zone of neurotransmitter release. Unlike mGluR4 and mGluR8, which share mGluR7’s presynaptic location, mGluR7 shows low affinity for glutamate and is activated only by ...
Palazzo E +4 more
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G-alpha interacting protein interacting protein, C terminus 1 regulates epileptogenesis by increasing the expression of metabotropic glutamate receptor 7. [PDF]
CNS Neurosci Ther, 2022 It has been reported that the G‐alpha interacting protein (GAIP) interacting protein, C terminus 1 (GIPC1/GIPC) engages in vesicular trafficking, receptor transport and expression, and endocytosis. However, its role in epilepsy is unclear.
Liu Y +7 more
europepmc +4 more sources
Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for the Treatment of Psychostimulant Dependence. [PDF]
CNS Neurol Disord Drug Targets, 2015 Although few medications have been approved by the U.S. Food and Drug Administration (FDA) to assist people to quit tobacco smoking, there are no FDA-approved medications to treat dependence on other psychostimulant drugs, such as cocaine. The motivation
Li X, Markou A.
europepmc +6 more sources
Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. [PDF]
J Neurosci, 2015 Of the eight metabotropic glutamate (mGlu) receptor subtypes, only mGlu7 is expressed presynaptically at the Schaffer collateral (SC)-CA1 synapse in the hippocampus in adult animals. Coupled with the inhibitory effects of Group III mGlu receptor agonists
Klar R +9 more
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