Can Metabotropic Glutamate Receptor 7 (mGluR 7) be a Novel Target for Analgesia? [PDF]
Journal of Clinical and Diagnostic Research, 2014 Introduction: The present study was carried out to study the role of metabotropic glutamate receptor 7 (mGluR7) using its agonist, N,N’-bis(diphenylmethyl)-1,-ethanediamine (AMN082) for nociceptive stimuli, in animal models.
Shivaprakash G +6 more
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Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders [PDF]
Frontiers in Molecular Neuroscience, 2018 Neurodevelopmental disorders (NDDs) are characterized by a wide range of symptoms including delayed speech, intellectual disability, motor dysfunction, social deficits, breathing problems, structural abnormalities, and epilepsy.
Nicole M. Fisher +5 more
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Constitutive activity of metabotropic glutamate receptor 7. [PDF]
BMC Neurosci, 2015 Metabotropic glutamate receptors (mGluRs) are class C G protein coupled receptors with widespread central nervous system expression. mGluR7 is a member of this family that has been implicated in numerous physiological and pathological processes, but the very low potency of mGluR7 for glutamate, its natural ligand, raise questions about the nature of ...
Kammermeier PJ.
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Corrigendum: Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders [PDF]
Frontiers in Molecular Neuroscience, 2018 [This corrects the article DOI: 10.3389/fnmol.2018.00387.].
Nicole M. Fisher +5 more
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Activating metabotropic glutamate receptor‑7 attenuates visceral hypersensitivity in neonatal maternally separated rats. [PDF]
Int J Mol Med, 2019 Increasing evidence has indicated that metabotropic glutamate receptor‑7 (mGluR7) is an important target for reducing anxiety and stress‑associated behaviours. Notably, mood disorders exhibit high levels of comorbidity with gastrointestinal dysfunction; however, the role of mGluR7 outside of the central nervous system is currently unknown.
Shao L +5 more
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A large consanguineous family with a homozygous Metabotropic Glutamate Receptor 7 (mGlu7) variant and developmental epileptic encephalopathy: Effect on protein structure and ligand affinity [PDF]
Orphanet Journal of Rare Diseases, 2021 Background Developmental and epileptic encephalopathies (DEE) are chronic neurological conditions where epileptic activity contributes to the progressive disruption of brain function, frequently leading to impaired motor, cognitive and sensory ...
Marwa Ben Jdila +6 more
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[Characterization of metabotropic glutamate receptor 7 and 8 in rat superior cervical ganglion and their changes following chronic intermittent hypoxia]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Wei X, Li C, Zhao C, Zhao B, Liu Y.
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G-alpha interacting protein interacting protein, C terminus 1 regulates epileptogenesis by increasing the expression of metabotropic glutamate receptor 7. [PDF]
CNS Neurosci Ther, 2022 Liu Y +7 more
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Increased amygdalar metabotropic glutamate receptor 7 mRNA in a genetic mouse model of impaired fear extinction. [PDF]
Psychopharmacology (Berl), 2019 O'Connor RM +5 more
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Clinical spectrum and outcomes of anti-metabotropic glutamate receptor 5 encephalitis in Chinese patients: a case report and literature review [PDF]
Frontiers in ImmunologyBackgroundAnti-metabotropic glutamate receptor 5 (mGluR5) encephalitis is a rare autoimmune disorder that targets the metabotropic glutamate receptor. It is frequently linked to limbic encephalitis and paraneoplastic syndromes, such as Ophelia syndrome ...
Zhenyu Niu +19 more
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