Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for the Treatment of Psychostimulant Dependence. [PDF]
CNS Neurol Disord Drug Targets, 2015 Although few medications have been approved by the U.S. Food and Drug Administration (FDA) to assist people to quit tobacco smoking, there are no FDA-approved medications to treat dependence on other psychostimulant drugs, such as cocaine. The motivation
Li X, Markou A.
europepmc +6 more sources
Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders. [PDF]
Mol PharmacolMetabotropic glutamate receptor 7 (mGlu7) is the most highly conserved and abundantly expressed mGlu receptor in the human brain. The presynaptic localization of mGlu7, coupled with its low affinity for its endogenous agonist, glutamate, are features ...
Parent HH, Niswender CM.
europepmc +4 more sources
Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7 [PDF]
The Journal of Neuroscience, 2001 To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to generate mice lacking this metabotropic receptor subtype (mGluR7−/−).
Gilles Sansig +19 more
semanticscholar +8 more sources
Regulation of N-Methyl-d-aspartic Acid (NMDA) Receptors by Metabotropic Glutamate Receptor 7* [PDF]
Journal of Biological Chemistry, 2012 Background: The metabotropic glutamate receptors (mGluRs) are potential novel targets for mental disorders. Results: Activation of mGluR7 significantly reduced NMDAR-mediated currents and NMDAR surface expression via an actin-dependent mechanism ...
Zhenglin Gu +3 more
semanticscholar +5 more sources
PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7 [PDF]
The EMBO Journal, 2002 Both postsynaptic density and presynaptic active zone are structural matrix containing scaffolding proteins that are involved in the organization of the synapse. Little is known about the functional role of these proteins in the signaling of presynaptic receptors.
Julie Perroy +6 more
semanticscholar +6 more sources
Blocking Metabotropic Glutamate Receptor Subtype 7 via the Venus Flytrap Domain Promotes a Chronic Stress-Resilient Phenotype in Mice [PDF]
Cells, 2022 Chronic psychosocial stress participates prominently in the etiology of various psychiatric conditions and comorbid somatic pathologies; however, suitable pharmacotherapy of these disorders is still of high medical need.
Karolyne A. R. Estrela +9 more
doaj +2 more sources
Interaction of the C‐terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1 [PDF]
European Journal of Neuroscience, 2000 Group III metabotropic glutamate receptors (mGluRs) are highly enriched in the presynaptic terminals of glutamatergic synapses where they mediate feedback inhibition of neurotransmitter release.
Oussama El Far +5 more
semanticscholar +3 more sources
Context-Dependent Pharmacology Exhibited by Negative Allosteric Modulators of Metabotropic Glutamate Receptor 7 [PDF]
Molecular Pharmacology, 2009 Phenotypic studies of mice lacking metabotropic glutamate receptor subtype 7 (mGluR7) suggest that antagonists of this receptor may be promising for the treatment of central nervous system disorders such as anxiety and depression. Suzuki et al. (J Pharmacol Exp Ther 323:147-156, 2007) recently reported the in vitro characterization of a novel mGluR7 ...
Colleen M. Niswender +9 more
semanticscholar +6 more sources
Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. [PDF]
ACS Chem Neurosci, 2014 Metabotropic glutamate receptor 7 (mGlu7) is a member of the group III mGlu receptors (mGlus), encompassed by mGlu4, mGlu6, mGlu7, and mGlu8. mGlu7 is highly expressed in the presynaptic active zones of both excitatory and inhibitory synapses, and ...
Jalan-Sakrikar N +22 more
europepmc +2 more sources
The Inhibition of Glutamate Release by Metabotropic Glutamate Receptor 7 Affects Both [Ca2+] and cAMP [PDF]
Journal of Biological Chemistry, 2002 Metabotropic glutamate receptors (mGluRs) from group III reduce glutamate release. Because these receptors reduce cAMP levels, we explored whether this signaling pathway contributes to release inhibition caused by mGluRs with low affinity forl-2-amino-4 ...
Carmelo Millán +3 more
openalex +2 more sources