Targeting Metabotropic Glutamate Receptor 7 Promotes Neurogenesis [PDF]
Abstract Human neural progenitor cells (hNPCs) have been reported to exist in various regions of the central nervous system (CNS) throughout the lifespan and to maintain homeostasis of the CNS. The endogenous NPC pools as well as their function decline during aging, neurodegeneration, or brain damage; therefore, supplementation with hNPCs or ...
Jian Zhao +10 more
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Metabotropic Glutamate Receptor 7: From Synaptic Function to Therapeutic Implications. [PDF]
Curr Neuropharmacol, 2016 Metabotropic glutamate receptor 7 (mGluR7) is localized presynaptically at the active zone of neurotransmitter release. Unlike mGluR4 and mGluR8, which share mGluR7's presynaptic location, mGluR7 shows low affinity for glutamate and is activated only by high glutamate concentrations.
Palazzo E +4 more
europepmc +5 more sources
Identification of Allosteric Modulators of Metabotropic Glutamate 7 Receptor Using Proteochemometric Modeling [PDF]
Journal of Chemical Information and Modeling, 2017 Proteochemometric modeling (PCM) is a computational approach that can be considered an extension of quantitative structure-activity relationship (QSAR) modeling, where a single model incorporates information for a family of targets and all the associated ligands instead of modeling activity versus one target.
Gary Tresadern +5 more
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Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists
Bioorganic & Medicinal Chemistry Letters, 2009 This Letter describes the synthesis and evaluation of mGluR7 antagonists in the isoxazolopyridone series. In the course of modification in this class, novel solid support synthesis of the isoxazolopyridone scaffold was developed. Subsequent chemical modification led to the identification of several potent derivatives with improved physicochemical ...
Masayuki Nakamura +5 more
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Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders. [PDF]
Mol PharmacolMetabotropic glutamate receptor 7 (mGlu7) is the most highly conserved and abundantly expressed mGlu receptor in the human brain. The presynaptic localization of mGlu7, coupled with its low affinity for its endogenous agonist, glutamate, are features that contribute to the receptor's role in modulating neuronal excitation and inhibition patterns ...
Parent HH, Niswender CM.
europepmc +3 more sources
Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7 [PDF]
The Journal of Neuroscience, 2001 To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to generate mice lacking this metabotropic receptor subtype (mGluR7−/−). After the serendipitous discovery of a sensory stimulus-evoked epileptic phenotype, we tested two convulsant drugs, pentylenetetrazole (PTZ) and bicuculline.
Gilles Sansig +19 more
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The role of metabotropic glutamate receptor 7 (mGluR7) in drug dependence [PDF]
Current Issues of Pharmacy and Medical Sciences, 2012 The successful pharmacotherapy for drug addiction is a challenge for pharmacology in XXI century. We still do not have any registered medication for cocaine by FDA, alcohol therapies are not enough successful. High hopes concern metabotropic glutamate 7 receptor as a target for pharmacotherapy development of drug dependence.
Małgorzata Jenda +2 more
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Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. [PDF]
ACS Chem Neurosci, 2014 Jalan-Sakrikar N +22 more
europepmc +2 more sources
The Inhibition of Glutamate Release by Metabotropic Glutamate Receptor 7 Affects Both [Ca2+] and cAMP [PDF]
Journal of Biological Chemistry, 2002 Carmelo Millán +3 more
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