Results 11 to 20 of about 385,222 (310)

Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7 [PDF]

The Journal of Neuroscience, 2001
To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to generate mice lacking this metabotropic receptor subtype (mGluR7−/−).
G. Sansig, T. Bushell, V. Clarke, A. Rozov, N. Burnashev, Chantal Portet, F. Gasparini, M. Schmutz, K. Klebs, R. Shigemoto, P. Flor, R. Kuhn, T. Knoepfel, Markus Schroeder, D. Hampson, V. J. Collett, Congxiao Zhang, R. Duvoisin, G. Collingridge, H. van der Putten   +19 more
semanticscholar   +8 more sources

PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7 [PDF]

The EMBO Journal, 2002
Both postsynaptic density and presynaptic active zone are structural matrix containing scaffolding proteins that are involved in the organization of the synapse. Little is known about the functional role of these proteins in the signaling of presynaptic receptors.
J. Perroy, O. Far, F. Bertaso, J. Pin, H. Betz, J. Bockaert, L. Fagni   +6 more
semanticscholar   +6 more sources

Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders. [PDF]

Mol Pharmacol
Metabotropic glutamate receptor 7 (mGlu7) is the most highly conserved and abundantly expressed mGlu receptor in the human brain. The presynaptic localization of mGlu7, coupled with its low affinity for its endogenous agonist, glutamate, are features ...
Parent HH, Niswender CM.
europepmc   +3 more sources

Increased amygdalar metabotropic glutamate receptor 7 mRNA in a genetic mouse model of impaired fear extinction. [PDF]

Psychopharmacology (Berl), 2019
O'Connor RM, McCafferty CP, Bravo JA, Singewald N, Holmes A, Cryan JF.   +5 more
europepmc   +4 more sources

Context-Dependent Pharmacology Exhibited by Negative Allosteric Modulators of Metabotropic Glutamate Receptor 7 [PDF]

Molecular Pharmacology, 2010
Phenotypic studies of mice lacking metabotropic glutamate receptor subtype 7 (mGluR7) suggest that antagonists of this receptor may be promising for the treatment of central nervous system disorders such as anxiety and depression. Suzuki et al. (J Pharmacol Exp Ther 323:147-156, 2007) recently reported the in vitro characterization of a novel mGluR7 ...
C. Niswender, Kari A. Johnson, Nicole R. Miller, J. Ayala, Qingwei Luo, R. Williams, Samir Saleh, D. Orton, C. D. Weaver, P. J. Conn   +9 more
semanticscholar   +6 more sources

Regulation of N-Methyl-d-aspartic Acid (NMDA) Receptors by Metabotropic Glutamate Receptor 7*♦ [PDF]

Journal of Biological Chemistry, 2012
Background: The metabotropic glutamate receptors (mGluRs) are potential novel targets for mental disorders. Results: Activation of mGluR7 significantly reduced NMDAR-mediated currents and NMDAR surface expression via an actin-dependent mechanism ...
Zhenglin Gu, Wenhua Liu, Jing Wei, Zhen Yan   +3 more
semanticscholar   +5 more sources

The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum [PDF]

Current Neuropharmacology, 2019
The dorsal striatum, apart from controlling voluntary movement, displays a recently demonstrated pain inhibition. It is connected to the descending pain modulatory system and in particular to the rostral ventromedial medulla through the medullary dorsal reticular nucleus.
Serena Boccella, Ida Marabese, Francesca Guida, Livio Luongo, Sabatino Maione, Enza Palazzo   +5 more
openalex   +4 more sources

The C Terminus of the Metabotropic Glutamate Receptor Subtypes 2 and 7 Specifies the Receptor Signaling Pathways [PDF]

Journal of Biological Chemistry, 2001
There is accumulating evidence that the specificity of the transduction cascades activated by G protein-coupled receptors cannot solely depend on the nature of the coupled G protein. To identify additional structural determinants, we studied two metabotropic glutamate (mGlu) receptors, the mGlu2 and mGlu7 receptors, that are both coupled to G(o ...
Julie Perroy, Gustavo J. Gutierrez, Vincent Coulon, Joël Bockaert, Jean‐Philippe Pin, Laurent Fagni   +5 more
openalex   +8 more sources

Interaction between metabotropic glutamate receptor 7 and alpha tubulin [PDF]

Journal of Neurochemistry, 2002
AbstractMetabotropic glutamate receptors (mGluRs) mediate a variety of responses to glutamate in the central nervous system. A primary role for group‐III mGluRs is to inhibit neurotransmitter release from presynaptic terminals, but the molecular mechanisms that regulate presynaptic trafficking and activity of group‐III mGluRs are not well understood ...
Julie A. Saugstad, Sufang Yang, Jan Pohl, Randy A. Hall, P. Jeffrey Conn   +4 more
openalex   +5 more sources

Blocking Metabotropic Glutamate Receptor Subtype 7 via the Venus Flytrap Domain Promotes a Chronic Stress-Resilient Phenotype in Mice [PDF]

Cells, 2022
Chronic psychosocial stress participates prominently in the etiology of various psychiatric conditions and comorbid somatic pathologies; however, suitable pharmacotherapy of these disorders is still of high medical need.
Karolyne A. R. Estrela, Lisa Senninger, Josephine Arndt, Melanie Kabas, Ferdinand Schmid, Larissa Dillmann, Sophia Auer, Thomas Stepfer, Peter J. Flor, Nicole Uschold-Schmidt   +9 more
doaj   +2 more sources