A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2005 Metabotropic glutamate receptor (mGluR) subtypes (mGluR1 to mGluR8) act as important pre- and postsynaptic regulators of neurotransmission in the CNS. These receptors consist of two domains, an extracellular region containing the orthosteric agonist site
Kayo Mitsukawa +12 more
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The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum [PDF]
Current Neuropharmacology, 2019 The dorsal striatum, apart from controlling voluntary movement, displays a recently demonstrated pain inhibition. It is connected to the descending pain modulatory system and in particular to the rostral ventromedial medulla through the medullary dorsal reticular nucleus.
Serena Boccella +5 more
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Interaction between metabotropic glutamate receptor 7 and alpha tubulin [PDF]
Journal of Neurochemistry, 2002 AbstractMetabotropic glutamate receptors (mGluRs) mediate a variety of responses to glutamate in the central nervous system. A primary role for group‐III mGluRs is to inhibit neurotransmitter release from presynaptic terminals, but the molecular mechanisms that regulate presynaptic trafficking and activity of group‐III mGluRs are not well understood ...
Julie A. Saugstad +4 more
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Pleiotropic Effects of Grm7/GRM7 in Shaping Neurodevelopmental Pathways and the Neural Substrate of Complex Behaviors and Disorders [PDF]
BiomoleculesNatural gene variants of metabotropic glutamate receptor subtype 7 (Grm7), coding for mGluR7, affect individuals’ alcohol-drinking preference. Psychopharmacological investigations have suggested that mGluR7 is also involved in responses to cocaine ...
Beatrix M. Gyetvai, Csaba Vadasz
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The C Terminus of the Metabotropic Glutamate Receptor Subtypes 2 and 7 Specifies the Receptor Signaling Pathways [PDF]
Journal of Biological Chemistry, 2001 There is accumulating evidence that the specificity of the transduction cascades activated by G protein-coupled receptors cannot solely depend on the nature of the coupled G protein. To identify additional structural determinants, we studied two metabotropic glutamate (mGlu) receptors, the mGlu2 and mGlu7 receptors, that are both coupled to G(o ...
Julie Perroy +5 more
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Concomitant Deficits in Working Memory and Fear Extinction Are Functionally Dissociated from Reduced Anxiety in Metabotropic Glutamate Receptor 7-Deficient Mice [PDF]
Journal of Neuroscience, 2006 Zsuzsanna Callaerts-Végh +7 more
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A Novel Connection between Rods and ON Cone Bipolar Cells Revealed by Ectopic Metabotropic Glutamate Receptor 7 (mGluR7) in mGluR6-Deficient Mouse Retinas [PDF]
Journal of Neuroscience, 2007 Yoshihiko Tsukamoto +6 more
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A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis [PDF]
Schizophrenia Research, 2020 Schizophrenia is an illness characterized by positive symptoms, negative symptoms, and cognitive impairments. Cognitive impairments occur before the onset of psychosis and could reflect glutamatergic dysregulation. Thus, identifying associations between genetic variations in genes coding for glutamatergic receptors and cognitive impairment in ...
B. Chaumette +10 more
semanticscholar +6 more sources
Progress toward allosteric ligands of metabotropic glutamate 7 (mGlu7) receptor: 2008–present [PDF]
MedChemComm, 2018 Metabotropic glutamate type 7 (mGlu7) receptor is a member of the group III family of mGlu receptors.
Henar Vázquez‐Villa +1 more
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