Results 21 to 30 of about 51,002 (254)
Regulation of N-Methyl-d-aspartic Acid (NMDA) Receptors by Metabotropic Glutamate Receptor 7* [PDF]
Journal of Biological Chemistry, 2012 Emerging evidence suggests that metabotropic glutamate receptors (mGluRs) are potential novel targets for brain disorders associated with the dysfunction of prefrontal cortex (PFC), a region critical for cognitive and emotional processes. Because N-methyl-D-aspartic acid receptor (NMDAR) dysregulation has been strongly associated with the ...
Zhenglin Gu +3 more
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European Psychiatry, 2023 Introduction Schizophrenia is a neuropsychiatric disorder characterised by positive, negative and cognitive behavioral symptoms. Despite years of research, the need for suitable therapy remains elusive.
R. O. Folarin, O. Owoeye, A. Malomo
doaj +1 more source
Interaction between metabotropic glutamate receptor 7 and alpha tubulin [PDF]
Journal of Neurochemistry, 2002 AbstractMetabotropic glutamate receptors (mGluRs) mediate a variety of responses to glutamate in the central nervous system. A primary role for group‐III mGluRs is to inhibit neurotransmitter release from presynaptic terminals, but the molecular mechanisms that regulate presynaptic trafficking and activity of group‐III mGluRs are not well understood ...
Julie A. Saugstad +4 more
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Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice [PDF]
PeerJ, 2015 Spinal astrocyte activation contributes to the pathogenesis of paclitaxel-induced neuropathic pain (PINP) in animal models. We examined glial fibrillary acidic protein (GFAP; an astrocyte marker) immunoreactivity and gene expression of GFAP, glutamate ...
Willias Masocha
doaj +2 more sources
Overexpression of mGluR7 in the Prefrontal Cortex Attenuates Autistic Behaviors in Mice
Frontiers in Cellular Neuroscience, 2021 Autism spectrum disorder (ASD) is associated with a range of abnormalities pertaining to socialization, communication, repetitive behaviors, and restricted interests. Owing to its complexity, the etiology of ASD remains incompletely understood.
Xiaona Wang +8 more
doaj +1 more source
Cells, 2022 Chronic psychosocial stress participates prominently in the etiology of various psychiatric conditions and comorbid somatic pathologies; however, suitable pharmacotherapy of these disorders is still of high medical need.
Karolyne A. R. Estrela +9 more
doaj +1 more source
Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for the Treatment of Psychostimulant Dependence. [PDF]
CNS Neurol Disord Drug Targets, 2015 Although few medications have been approved by the U.S. Food and Drug Administration (FDA) to assist people to quit tobacco smoking, there are no FDA-approved medications to treat dependence on other psychostimulant drugs, such as cocaine. The motivation to maintain psychostimulant drug seeking and self-administration involves alterations in ...
Li X, Markou A.
europepmc +4 more sources
Brazilian Journal of Otorhinolaryngology, 2019 Introduction: Sensorineural hearing loss is a common challenge all over the world, including a section of the young population. While there have been many published reports associating glutamate metabotropic receptor 7 with sensorineural hearing loss ...
Sanlin Xie +3 more
doaj +1 more source
Progress toward allosteric ligands of metabotropic glutamate 7 (mGlu7) receptor: 2008–present [PDF]
MedChemComm, 2018 Metabotropic glutamate type 7 (mGlu7) receptor is a member of the group III family of mGlu receptors.
Henar Vázquez‐Villa +1 more
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Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction. [PDF]
, 2016 BACKGROUND: A difficult problem in treating opioid addicts is the maintenance of a drug-free state because of the negative emotional symptoms associated with withdrawal, which may trigger relapse.
Bailey, A +8 more
core +1 more source