A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis [PDF]
Schizophrenia Research, 2020 Schizophrenia is an illness characterized by positive symptoms, negative symptoms, and cognitive impairments. Cognitive impairments occur before the onset of psychosis and could reflect glutamatergic dysregulation. Thus, identifying associations between genetic variations in genes coding for glutamatergic receptors and cognitive impairment in ...
B. Chaumette +10 more
semanticscholar +6 more sources
Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1. [PDF]
European Journal of Neuroscience, 2000 Group III metabotropic glutamate receptors (mGluRs) are highly enriched in the presynaptic terminals of glutamatergic synapses where they mediate feedback inhibition of neurotransmitter release.
O. Far +5 more
semanticscholar +3 more sources
Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. [PDF]
ACS Chem Neurosci, 2014 Metabotropic glutamate receptor 7 (mGlu7) is a member of the group III mGlu receptors (mGlus), encompassed by mGlu4, mGlu6, mGlu7, and mGlu8. mGlu7 is highly expressed in the presynaptic active zones of both excitatory and inhibitory synapses, and ...
Jalan-Sakrikar N +22 more
europepmc +2 more sources
The Inhibition of Glutamate Release by Metabotropic Glutamate Receptor 7 Affects Both [Ca2+] c and cAMP [PDF]
Journal of Biological Chemistry, 2002 Metabotropic glutamate receptors (mGluRs) from group III reduce glutamate release. Because these receptors reduce cAMP levels, we explored whether this signaling pathway contributes to release inhibition caused by mGluRs with low affinity forl-2-amino-4 ...
Carmelo Millán +3 more
semanticscholar +2 more sources
Progress toward allosteric ligands of metabotropic glutamate 7 (mGlu7) receptor: 2008–present [PDF]
MedChemComm, 2018 Metabotropic glutamate type 7 (mGlu7) receptor is a member of the group III family of mGlu receptors.
Henar Vázquez‐Villa +1 more
openalex +4 more sources
The role of metabotropic glutamate receptor 7 (mGluR7) in drug dependence [PDF]
Current Issues of Pharmacy and Medical Sciences, 2012 The successful pharmacotherapy for drug addiction is a challenge for pharmacology in XXI century. We still do not have any registered medication for cocaine by FDA, alcohol therapies are not enough successful. High hopes concern metabotropic glutamate 7 receptor as a target for pharmacotherapy development of drug dependence.
Małgorzata Jenda +2 more
openalex +3 more sources
Metabotropic glutamate 7 (mGlu7) receptor: A target for medication development for the treatment of cocaine dependence [PDF]
Neuropharmacology, 2012 Brain glutamate has been shown to play an important role in reinstatement to drug seeking, a behavior considered to be of relevance to relapse to drug taking in humans. Therefore, glutamate receptors, in particular metabotropic glutamate (mGlu) receptors, have become important targets for medication development for the treatment of drug dependence.
Xia Li, Zheng‐Xiong Xi, Athina Markou
openalex +4 more sources
A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2005 Metabotropic glutamate receptor (mGluR) subtypes (mGluR1 to mGluR8) act as important pre- and postsynaptic regulators of neurotransmission in the CNS. These receptors consist of two domains, an extracellular region containing the orthosteric agonist site
Kayo Mitsukawa +12 more
semanticscholar +2 more sources
Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking
Genomics, 2007 Alcoholism is a heritable disease that afflicts about 8% of the adult population. Its development and symptoms, such as craving, loss of control, physical dependence, and tolerance, have been linked to changes in mesolimbic, mesocortical neurotransmitter systems utilizing biogenic amines, GABA, and glutamate.
Csaba Vadász +7 more
openalex +4 more sources
Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats [PDF]
Journal of Negative Results in BioMedicine, 2009 A complete explanation of the mechanisms by which Pb2+ exerts toxic effects on developmental central nervous system remains unknown. Glutamate is critical to the developing brain through various subtypes of ionotropic or metabotropic glutamate receptors (mGluRs).
Jian Xu +5 more
openalex +5 more sources