Results 51 to 60 of about 385,222 (310)

Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats

BMC Neuroscience, 2008
Background Many studies have focused on the implication of the serotonin and dopamine systems in neuroadaptive responses to the recreational drug 3,4-methylenedioxy-metamphetamine (MDMA).
Malki Rana, Blomqvist Anna, Kindlundh-Högberg Anna MS, Schiöth Helgi B   +3 more
doaj   +1 more source

Acute Alcohol-Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography. [PDF]

Addict Biol
This proof‐of‐concept study provides evidence that acute alcohol administration reduces mGluR5 availability and increases relative blood flow in the human brain, as measured by [11C]ABP688 PET. The observed effects align with preclinical evidence of alcohol‐induced glutamate release.
Raval NR, Smart K, Angarita GA, Miller R, Huang Y, Krystal JH, Carson RE, Cosgrove KP, O'Malley SS, Hillmer AT.   +9 more
europepmc   +2 more sources

Analysis of metabotropic glutamate receptor 7 as a potential substrate for SUMOylation

Neuroscience Letters, 2011
Group III metabotropic glutamate receptors (mGluRs) undergo post-translational modification by SUMO in in vitro assays but the SUMOylation of full-length mGluRs in mammalian cells has not been reported. Here we investigated SUMOylation of mGluR7 in HEK293 cells and primary cortical neurons in an attempt to confirm SUMOylation and define physiological ...
Wilkinson, KA, Henley, JM
openaire   +4 more sources

Mechanisms associated with activation of intracellular metabotropic glutamate receptor, mGluR5 [PDF]

, 2016
The group 1 metabotropic glutamate receptor, mGluR5, is found on the cell surface as well as on intracellular membranes where it can mediate both overlapping and unique signaling effects.
Jong, Yuh-Jiin I, O\u27Malley, Karen L
core   +2 more sources

Computational Drug Design Applied to the Study of Metabotropic Glutamate Receptors

Molecules, 2019
Metabotropic glutamate (mGlu) receptors are a family of eight GPCRs that are attractive drug discovery targets to modulate glutamate action and response. Here we review the application of computational methods to the study of this family of receptors.
Claudia Llinas del Torrent, Laura Pérez-Benito, Gary Tresadern   +2 more
doaj   +1 more source

Identification of Allosteric Modulators of Metabotropic Glutamate 7 Receptor Using Proteochemometric Modeling [PDF]

Journal of Chemical Information and Modeling, 2017
Proteochemometric modeling (PCM) is a computational approach that can be considered an extension of quantitative structure-activity relationship (QSAR) modeling, where a single model incorporates information for a family of targets and all the associated ligands instead of modeling activity versus one target.
Gary Tresadern, Andres A. Trabanco, Laura Pérez-Benito, John P. Overington, Herman W. T. van Vlijmen, Gerard J. P. van Westen   +5 more
openaire   +4 more sources

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]

, 2018
In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba, Cristina Zappulla, Ferdinando Nicoletti, Francesca Liberatore, Giada Mascio, Giorgio Carmignoto, Giuseppe Battaglia, Harumi Nakao, Marta Motolese, Masahiko Watanabe, Micaela Zonta, Michele Madonna, Milena Cannella, Pamela Scarselli, Roberto Gradini, Serena Notartomaso, Valeria Bruno   +16 more
core   +2 more sources

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]

, 2017
Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe, Bernabucci, Matteo, Bruno, Valeria Maria Gloria, Cannella, Milena, Gradini, Roberto, Imbriglio, Tiziana, Mascio, Giada, Nicoletti, Ferdinando, Notartomaso, Serena, Scarselli, Pamela, Zappulla, Cristina   +10 more
core   +1 more source

Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]

Physical Review E 82, 041902 (2010), 2010
The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv   +1 more source

Phasic and tonic mGlu7 receptor activity modulates the thalamocortical network

Frontiers in Neural Circuits, 2016
Mutation of the metabotropic glutamate receptor type 7 (mGlu7) induces absence-like epileptic seizures, but its precise role in the somatosensory thalamocortical network remains unknown.
Valériane eTassin, Valériane eTassin, Valériane eTassin, Benoit eGirard, Benoit eGirard, Benoit eGirard, Apolline eChotte, Apolline eChotte, Apolline eChotte, Pierre eFontanaud, Pierre eFontanaud, Pierre eFontanaud, Delphine eRigault, Mikhail eKalinichev, Julie ePerroy, Julie ePerroy, Julie ePerroy, Francine eAcher, Laurent eFagni, Laurent eFagni, Laurent eFagni, Federica eBertaso, Federica eBertaso, Federica eBertaso   +23 more
doaj   +1 more source