Results 221 to 230 of about 2,317,385 (378)

The effects of (RS)‐α‐cyclopropyl‐4‐phosphonophenylglycine ((RS)‐CPPG), a potent and selective metabotropic glutamate receptor antagonist [PDF]

, 1996
Nick J. Toms, David E. Jane, Martyn C. Kemp, Jennifer S. Bedingfield, Peter Roberts‎   +4 more
openalex   +1 more source

Penta‐ALFA‐Tagged Substrates for Self‐Labelling Tags Allow Signal Enhancement in Microscopy

Journal of Peptide Science, Volume 31, Issue 5, May 2025.
A pentaALFA peptide may be reacted with a SNAP‐ or HaloTag and allows for signal enhancement using fluorescently labelled nanobodies. Tagged and peptide/nanobody treated cell surface receptors give generally higher signal intensity using fluorescence microscopy and are amenable for stimulated emission by depletion (STED) super‐resolution imaging ...
Souvik Ghosh, Ramona Birke, Ashwin Karthick Natarajan, Johannes Broichhagen   +3 more
wiley   +1 more source

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome

Journal of Experimental Pharmacology, 2013
Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
doaj  

Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes: A possible factor regulating synaptic protein synthesis [PDF]

, 1998
Frank Angenstein, William T. Greenough, Ivan Jeanne Weiler   +2 more
openalex   +1 more source

Development of a high‐throughput dual‐stream liquid chromatography–tandem mass spectrometry method to screen for inhibitors of glutamate carboxypeptidase II

Rapid Communications in Mass Spectrometry, Volume 39, Issue S1, May 2025.
Rationale Glutamate carboxypeptidase II (GCPII) catalyzes the hydrolysis of N‐acetylaspartylglutamate (NAAG) to yield glutamate (Glu) and N‐acetylaspartate (NAA). Inhibition of GCPII has been shown to remediate the neurotoxicity of excess Glu in a variety of cell and animal disease models.
Nate Hoxie, Yixuan Qiu, Stephen C. Kales, Rick Schneider, Xin Hu, Anu Dalal, Stephanie L. Ford‐Scheimer, Robyn Wiseman, Takashi Tsukamoto, Huijun Wei, Barbara S. Slusher, John S. Janiszewski, Matthew D. Hall   +12 more
wiley   +1 more source

Ca2+-Dependent Induction of Intracellular Ca2+ Oscillation in Hippocampal Astrocytes During Metabotropic Glutamate Receptor Activation

Journal of Pharmacological Sciences, 2005
We have investigated whether the intracellular calcium concentration ([Ca2+]i) oscillations induced in astrocytes using the metabotropic glutamate-receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) are Ca2+-dependent, using ...
Yoshitoku Yoshida, Remi Tsuchiya, Nagisa Matsumoto, Mitsuhiro Morita, Hiroyoshi Miyakawa, Yoshihisa Kudo   +5 more
doaj  

Glutamate metabotropic receptor 4 (GRM4) inhibits cell proliferation, migration and invasion in breast cancer and is regulated by miR-328-3p and miR-370-3p. [PDF]

BMC Cancer, 2019
Xiao B, Chen D, Zhou Q, Hang J, Zhang W, Kuang Z, Sun Z, Li L.   +7 more
europepmc   +1 more source

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

Science, 2014
Huixian Wu, Chong Wang, K. Gregory, K. Gregory, G. Han, Hyekyung P. Cho, Yao Xia, C. Niswender, V. Katritch, J. Meiler, V. Cherezov, P. Conn, R. Stevens   +12 more
semanticscholar   +1 more source

Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus [PDF]

, 1996
Domenico E. Pellegrini‐Giampietro, Serenella Albani Torregrossa, Flavio Moroni   +2 more
openalex   +1 more source