Results 311 to 320 of about 2,317,385 (378)

Metabotropic glutamate receptors

Amino Acids, 2007
l-Glutamate, one of the main neurotransmitters in the central nervous system (CNS), acts on two groups of receptors: (a) a group of ionotropic receptors that includes N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA), and kainate receptors, and (2) a group of metabotropic receptors (mGluRs).
Andrzej Pilc, Krystyna Ossowska
openaire   +2 more sources

Metabotropic Glutamate Receptors and Neurodegeneration

2004
Metabotropic glutamate (mGlu) receptors, which exert a modulatory effect on excitatory synaptic transmission, are considered as potential targets for neuroprotective drugs and the advent of potent and centrally available subtype-selective ligands has lead to an extensive investigation of the role of individual mGlu receptor subtypes in ...
BRUNO, Valeria Maria Gloria, BATTAGLIA, Giuseppe, A. Copani, G. Casabona, M. Storto, V. D. Giorgi, R. Ngomba, NICOLETTI, Ferdinando   +7 more
openaire   +6 more sources

Structure of the metabotropic glutamate receptor

Current Opinion in Neurobiology, 2003
In the twelve years since the molecular elucidation of the metabotropic glutamate receptor subtype 1, a class III family of G-protein-coupled receptors has emerged; members of this family include the calcium-sensing receptor, the GABA(B) receptor, some odorant receptors and some taste receptors.
Shigetada Nakanishi, Hisato Jingami, Kosuke Morikawa   +2 more
openaire   +2 more sources

A family of metabotropic glutamate receptors

Neuron, 1992
Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is
Yasuto Tanabe, Shigetada Nakanishi, Masayuki Masu, Ryuichi Shigemoto, Takahiro Ishii   +4 more
openaire   +3 more sources

Metabotropic glutamate receptors and epilepsy

Journal of the Neurological Sciences, 2006
Metabotropic glutamate receptors (mGluRs) play an important role in the initiation of ictal discharges by participating in the interictal-ictal transition, and may play a crucial role in recruiting normal brain tissue into synchronized discharges, thereby facilitating propagation of seizure activity.
Michel Baudry, Mónica Perassolo, Jorge A. Ure   +2 more
openaire   +3 more sources

Metabotropic Glutamate Receptors in Glial Cells

Neurochemical Research, 2008
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its actions via a number of ionotropic glutamate receptors/channels and metabotropic glutamate (mGlu) receptors. In addition to being expressed in neurons, glutamate receptors are expressed in different types of glial cells including astrocytes ...
Simona D'Antoni, Antonio Berretta, Carmela Maria Bonaccorso, BRUNO, Valeria Maria Gloria, Eleonora Aronica, NICOLETTI, Ferdinando, Maria Vincenza Catania   +6 more
openaire   +6 more sources

Metabotropic Glutamate Receptors as Drug Targets

Current Drug Targets, 2007
L-glutamate (Glu), the main excitatory amino acid neurotransmitter in the mammalian central nervous system, is involved in many physiological functions, including learning and memory, but also in toxic phenomena occurring in numerous degenerative or neurological diseases.
Récasens, Max, Guiramand, Janique, Aimar, Rose, Abdulkarim, Ahmad, Barbanel, Gérard   +4 more
openaire   +4 more sources

Metabotropic glutamate receptors, 5 years on

Neuropharmacology, 2017
[no abstract]
Collingridge, Graham L., Manahan Vaughan, Denise, NICOLETTI, Ferdinando, Schoepp, Darryle D.   +3 more
openaire   +4 more sources

Metabotropic receptor-mediated Ca2+ signaling elevates mitochondrial Ca2+ and stimulates oxidative metabolism in hippocampal slice cultures.

Journal of Neurophysiology, 2003
Metabotropic receptors modulate numerous cellular processes by intracellular Ca2+ signaling, but less is known about their role in regulating mitochondrial metabolic function within the CNS.
O. Kann, R. Kovács, U. Heinemann
semanticscholar   +1 more source

Metabotropic Glutamate Receptors and Neuronal Toxicity

1992
Specific glutamate receptors coupled to polyphosphoinositide (PPI) hydrolysis have been described in brain slices, cultured neurons, and astrocytes, and in amphibian oocytes injected with rat brain mRNA (Sladeczek et al., 1985; Nicoletti et al., 1986a,b; Sugiyama et al., 1987).
ALEPPO G, PISANI A, COPANI A, BRUNO V, ARONICA E, D'AGATA V, CANONICO P. L, NICOLETTI F   +7 more
openaire   +6 more sources