Results 81 to 90 of about 2,328,855 (357)
Diverse Subpopulations of Reactive Astrocytes Following Chronic Toxoplasma Infection
Glia, EarlyView.Toxoplasma infection results in distinct astrocyte subpopulations. Chronically labeled reactive astrocytes appear transcriptionally plastic and can regain acute inflammatory responding and naive homeostatic astrocytic gene patterns in the presence of ongoing neuroinflammation.
Zoe A. Figueroa +7 more
wiley +1 more source
Metabotropic glutamate receptor 5 (mGluR5) regulates white adipocyte browning [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate whether mGluR5 could regulate white adipocytes browning. Methods Western blot was used to test the expression of mGluR5 in white and brown adipose tissue. Lipid droplets morphology was microscoped after BODIPY staining.
LUO Xie, ZENG Li, YUAN Lei
doaj
Metabotropic Glutamate Receptor Activation in Cerebelar Purkinje Cells as Substrate for Adaptive Timing of the Classicaly Conditioned Eye Blink Response [PDF]
, 1995 To understand how the cerebellum adaptively times the classically conditioned nictitating membrane response (NMR), a model of the metabotropic glutamate receptor (mGluR) second messenger system in cerebellar Purkinje cells is constructed.
Bullock, Daniel +2 more
core +1 more source
The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]
, 2014 G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F +12 more
core +4 more sources
Investigative Ophthalmology and Visual Science, 2008 PURPOSE Metabotropic receptor agonists that signal through G(q)-coupled pathways increase Ca(2+) in mammalian Müller cells by release from intracellular stores and Ca(2+) influx pathways that have not been well described.
N. Da Silva +5 more
semanticscholar +1 more source
Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia
Glia, EarlyView.Adrenergic signaling through ADRB2 modulates phagocytosis in microglia. Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia. ADRB2 activation inhibits both P2Y6 function and gene expression. ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their environment ...
Thomas Deluc +10 more
wiley +1 more source
Journal of Pharmacological Sciences, 2015 The adenosine A1 receptor (A1R) is a G protein-coupled receptor (GPCR) for adenosine, a ubiquitous neuromodulator, and thus regulates neuronal excitability, as well as arousal and sensitivity to pain.
Yuji Kamikubo +4 more
doaj +1 more source
Oxygen/Glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors [PDF]
, 2011 Hippocampal CA1 pyramidal neurons are highly sensitive to ischemic damage, whereas neighboring CA3 pyramidal neurons are less susceptible. It is proposed that switching of AMPA receptor (AMPAR) subunits on CA1 neurons during an in vitro model of ischemia,
Cimarosti, Helena +5 more
core +1 more source
Movement Disorders, EarlyView.Abstract Background Fatigue in Parkinson's disease (PD) is a prevalent and debilitating non‐motor symptom. Despite its significant impact on quality of life, the underlying neurochemical and network‐based mechanisms remain poorly understood. Objectives This observational study applied a multimodal imaging approach to explore potential links between the
Ilaria Antonella Di Vico +14 more
wiley +1 more source
Assembly and Cooperativity of Metabotropic Glutamate Receptors [PDF]
Biophysical Journal, 2015 Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are found throughout the nervous system where they respond to the major excitatory neurotransmitter, glutamate, to modulate synaptic transmission and plasticity via a variety of effectors.
Levitz, Josh +4 more
openaire +2 more sources