Results 101 to 110 of about 152,360 (260)
PrOMet: Accurate and Robust Metal‐Binding Site and Type Prediction
Advanced Science, EarlyView.PrOMet is a two‐stage deep learning framework for jointly predicting metal‐binding sites and ion identities from protein structures. Surface candidate sites are first pruned, followed by refinement of the most probable sites and metal types. This hierarchical strategy enables robust and accurate metal prediction for cryo‐EM and AlphaFold‐derived ...
Gangeun Park, Chaok Seok, Hahnbeom Park
wiley +1 more source
Advanced Science, EarlyView.SLC25A4high hepatocytes drive metabolic‐associated steatotic liver disease (MASLD) remission by recruiting lipid‐eating macrophages. The hepatocyte Slc25a4/PANX1/ATP/P2ry12 axis mediates find‐me signaling that triggers macrophage recruitment and efferocytosis, while recruited macrophages secrete GDF15 to activate hepatocyte PPARα and promote fatty acid
Yiting Qian +8 more
wiley +1 more source
Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2017 In this paper we describe the implementation of a classification server that helps in metadata organization for a long term reservation system of digital objects.
Sándor Kopácsi† +2 more
doaj
Advanced Science, EarlyView.Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang +9 more
wiley +1 more source
Advanced Science, EarlyView.DAIMS is a multimodal model for treatment stratified risk and survival assessment in colorectal cancer. Training draws on pathology, genomics, and clinical reports, yet inference requires only whole slide images, and adaptation to new cohorts proceeds without target survival outcomes.
Chuangjie Cao +15 more
wiley +1 more source
Mental Files. Triggering Mechanisms, Metadata and ‘Discernibility of Identicals’
Studia Semiotyczne, 2019 DOI: http://doi.org/10.26333/sts.xxxi2.02 This paper initially follows the final part of the debate between singularism and descriptivism to the point of convergence, and discusses the notion of acquaintanceless singular thought (such that there is a ...
Mieszko Tałasiewicz
doaj
Drug Repurposing for Treating NCOR‐Related Intellectual Disability
Advanced Science, EarlyView.An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong +15 more
wiley +1 more source
Advanced Science, EarlyView.Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li +9 more
wiley +1 more source
L'esperienza del Dipartimento della Protezione Civile sulle specifiche RNDT
GEOmedia, 2012 Il Comitato per le regole tecniche sui dati territoriali delle pubbliche amministrazioni ha approvato un provvedimento con il quale si definiscono le regole tecniche per la formazione e l’alimentazione del RepertorioNazionale dei Dati Territoriali (RNDT),
Pierluigi Cara
doaj
Advanced Science, EarlyView.RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan +8 more
wiley +1 more source