Results 11 to 20 of about 10,019 (225)

A regulatory science initiative to harmonize and standardize digital pathology and machine learning processes to speed up clinical innovation to patients

Journal of Pathology Informatics, 2020
Unlocking the full potential of pathology data by gaining computational access to histological pixel data and metadata (digital pathology) is one of the key promises of computational pathology. Despite scientific progress and several regulatory approvals
Hetal Desai Marble, Richard Huang, Sarah Nixon Dudgeon, Amanda Lowe, Markus D Herrmann, Scott Blakely, Matthew O Leavitt, Mike Isaacs, Matthew G Hanna, Ashish Sharma, Jithesh Veetil, Pamela Goldberg, Joachim H Schmid, Laura Lasiter, Brandon D Gallas, Esther Abels, Jochen K Lennerz   +16 more
doaj   +1 more source

Research on the Coupled Representation of Model and Data Integration Guided by Metadata Sets [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Aiming at the problems of islands, redundancy and sharing difficulties of spatial and temporal business models and data in geospatial and spatial business systems, this paper proposes an integrated and coupled expression method of models and data guided ...
Y. Li, L. Huo, W. Zhu, P. Bao, M. Zhang, B. Li   +5 more
doaj   +1 more source

Documentation and Visualisation of Workflows for Effective Communication, Collaboration and Publication @ Source

International Journal of Digital Curation, 2017
Workflows processing data from research activities and driving in silico experiments are becoming an increasingly important method for conducting scientific research.
Cerys Willoughby, Jeremy G. Frey
doaj   +1 more source

Renewable Energy Sources and the New Paradigm in Energy Engineering

Renewable Energy and Sustainable Development, 2019
After centuries of scientific, industrial and technological achievements the current paradigm in energy engineering may be defined as the complex set of knowledge, technologies, policies but even individual and community attitudes aiming to assure at the
Eden Mamut
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source