Intrabacterial Regulation of a Cytotoxic Effector by Its Cognate Metaeffector Promotes Legionella pneumophila Virulence [PDF]
mSphere, 2023 Legionella pneumophila is a natural pathogen of unicellular protozoa that can opportunistically infect macrophages and cause Legionnaires’ Disease. Intracellular replication is driven by hundreds of bacterial effector proteins that are translocated into ...
Deepika Chauhan +2 more
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Affecting the Effectors: Regulation of Legionella pneumophila Effector Function by Metaeffectors [PDF]
Pathogens, 2021 Many bacterial pathogens utilize translocated virulence factors called effectors to successfully infect their host. Within the host cell, effector proteins facilitate pathogen replication through subversion of host cell targets and processes.
Ashley M. Joseph, Stephanie R. Shames
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Metaeffector interactions modulate the type III effector-triggered immunity load of Pseudomonas syringae. [PDF]
PLoS Pathogens, 2022 The bacterial plant pathogen Pseudomonas syringae requires type III secreted effectors (T3SEs) for pathogenesis. However, a major facet of plant immunity entails the recognition of a subset of P.
Alexandre Martel +6 more
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Legionella pneumophila temporally regulates the activity of ADP/ATP translocases by reversible ADP‐ribosylation [PDF]
mLife, 2022 The mitochondrion is an important signaling hub that governs diverse cellular functions, including metabolism, energy production, and immunity. Among the hundreds of effectors translocated into host cells by the Dot/Icm system of Legionella pneumophila ...
Jiaqi Fu +6 more
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Legionella pneumophila modulates the host cytoskeleton by an effector of transglutaminase activity [PDF]
mLifeThe bacterial pathogen Legionella pneumophila delivers more than 330 effector proteins into host cells through its Dot/Icm type IV secretion system (T4SS) to facilitate its intracellular replication.
Yan Liu, Yao Liu, Zhao‐Qing Luo
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Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila [PDF]
Molecular Systems Biology, 2016 Pathogens deliver complex arsenals of translocated effector proteins to host cells during infection, but the extent to which these proteins are regulated once inside the eukaryotic cell remains poorly defined.
Malene L Urbanus +15 more
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Structural basis for the toxicity of Legionella pneumophila effector SidH [PDF]
Nature Communications, 2023 Legionella pneumophila (LP) secretes more than 300 effectors into the host cytosol to facilitate intracellular replication. One of these effectors, SidH, 253 kDa in size with no sequence similarity to proteins of known function is toxic when ...
Rahul Sharma +11 more
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Structural basis for protein glutamylation by the Legionella pseudokinase SidJ [PDF]
Nature Communications, 2021 Legionella pneumophila (LP) employs the metaeffector SidJ to suppress the toxicity of SdeA and other LP SidE effector family members by catalysing the glutamylation of the catalytic Glu residue. Here, the authors present the cryo-EM structures of SidJ in
Michael Adams +5 more
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A comprehensive two-hybrid analysis to explore the Legionella pneumophila effector–effector interactome [PDF]
mSystemsLegionella pneumophila uses over 300 translocated effector proteins to rewire host cells during infection and create a replicative niche for intracellular growth. To date, several studies have identified L.
Harley O'Connor Mount +16 more
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Modulation of host ATP levels by secreted bacterial effectors [PDF]
Nature CommunicationsAdenosine 5′-triphosphate (ATP) is the currency of energy in cells; it plays essential roles in virtually all cellular processes, ranging from basic metabolism to signaling in development and disease.
Chunlin He +12 more
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