Spatiotemporal regulation of a Legionella pneumophila T4SS substrate by the metaeffector SidJ. [PDF]
PLoS Pathogens, 2015 Modulation of host cell function is vital for intracellular pathogens to survive and replicate within host cells. Most commonly, these pathogens utilize specialized secretion systems to inject substrates (also called effector proteins) that function as ...
Kwang Cheol Jeong +2 more
doaj +13 more sources
Bacterial effector-involved temporal and spatial regulation by hijack of the host ubiquitin pathway [PDF]
Frontiers in Cellular and Infection Microbiology, 2011 Ubiquitination is one of the most conserved post-translational modifications of proteins, and is involved in essential eukaryotic cellular processes.
Tomoko eKubori +2 more
doaj +4 more sources
Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain [PDF]
Nature CommunicationsADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major family in this category.
Zhengrui Zhang +8 more
doaj +5 more sources
Legionella metaeffector exploits host proteasome to temporally regulate cognate effector. [PDF]
PLoS Pathogens, 2010 Pathogen-associated secretion systems translocate numerous effector proteins into eukaryotic host cells to coordinate cellular processes important for infection.
Tomoko Kubori +3 more
doaj +5 more sources
Dual Control of Host Actin Polymerization by a Legionella Effector Pair
Cellular MicrobiologyHost actin cytoskeleton is often targeted by pathogenic bacteria through the secretion of effectors. Legionella pneumophila virulence relies on the injection of the largest known arsenal of bacterial proteins, over 300 Dot/Icm type 4 secretion system ...
M. Pillon +11 more
doaj +2 more sources
The metaeffector MesI regulates the activity of the Legionella effector SidI through direct protein-protein interactions. [PDF]
Microbes Infect, 2021 To create an intracellular niche permissive for its replication, Legionella pneumophila uses hundreds of effectors to target a wide variety of host proteins and manipulate specific host processes such as immune response, and vesicle trafficking. To avoid unwanted disruption of host physiology, this pathogen also imposes precise control of its virulence
McCloskey A +4 more
europepmc +3 more sources
The Legionella pneumophila Metaeffector Lpg2505 (MesI) Regulates SidI-Mediated Translation Inhibition and Novel Glycosyl Hydrolase Activity. [PDF]
Infect Immun, 2020 Legionella pneumophila , the etiological agent of Legionnaires’ disease, employs an arsenal of hundreds of Dot/Icm-translocated effector proteins to facilitate replication within eukaryotic phagocytes. Several effectors, called metaeffectors, function to regulate the activity of other Dot/Icm-translocated effectors during ...
Joseph AM +6 more
europepmc +4 more sources
Crystal structure of the metaeffector MesI (Lpg2505) from Legionella pneumophila [PDF]
Biochemical and Biophysical Research Communications, 2020 Persistence and replication of the gram-negative bacterium Legionella pneumophila in the human host cell depend on so-called effector proteins that target diverse cellular functions and modulate them in favor of the pathogen. We solved the crystal structure of the L. pneumophila effector protein MesI de novo to a resolution of 2.2 Å.
Dominik A. Machtens +3 more
openaire +3 more sources
Repertoire and abundance of secreted virulence factors shape the pathogenic capacity of <i>Pseudomonas syringae</i> pv. aptata. [PDF]
Front Microbiol, 2023 Pseudomonas syringae pv. aptata is a member of the sugar beet pathobiome and the causative agent of leaf spot disease. Like many pathogenic bacteria, P. syringae relies on the secretion of toxins, which manipulate host-pathogen interactions, to establish
Nikolić I +5 more
europepmc +3 more sources
Suppression of NLR-mediated plant immune detection by bacterial pathogens. [PDF]
, 2023 The plant immune system is constituted of two functionally interdependent branches that provide the plant with an effective defense against microbial pathogens.
Rufián Plaza, José Sebastián +3 more
core +1 more source