A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response [PDF]
, 2023 A widespread strategy employed by pathogens to establish infection is to inhibit host-cell protein synthesis. Legionella pneumophila, an intracellular bacterial pathogen and the causative organism of Legionnaires' disease, secretes a subset of protein ...
Burlingame, Alma L +16 more
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Molecular Plant-Microbe Interactions, 2022 The predicted repertoire of type III secretion system effectors (T3SEs) in Erwinia tracheiphila, causal agent of cucurbit bacterial wilt, is much larger than in xylem pathogens in the closely related genera Erwinia and Pantoea.
Olakunle I. Olawole +2 more
doaj +1 more source
Polar targeting and assembly of the Legionella Dot/Icm type IV secretion system (T4SS) by T6SS-related components [PDF]
, 2018 Legionella pneumophila, the causative agent of Legionnaires′ disease, survives and replicates inside amoebae and macrophages by injecting a large number of protein effectors into the host cells′ cytoplasm via the Dot/Icm type IVB secretion system (T4BSS).
Ghosal, Debnath +5 more
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Interesting biochemistries in the structure and function of bacterial effectors [PDF]
, 2021 Bacterial effector proteins, delivered into host cells by specialized multiprotein secretion systems, are a key mediator of bacterial pathogenesis. Following delivery, they modulate a range of host cellular processes and functions.
Mak, H, Thurston, T
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Polar delivery of Legionella type IV secretion system substrates is essential for virulence [PDF]
, 2017 A recurrent emerging theme is the targeting of proteins to subcellular microdomains within bacterial cells, particularly to the poles. In most cases, it has been assumed that this localization is critical to the protein’s function. Legionella pneumophila
Chang, Yi-Wei +4 more
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The Rab-binding profiles of bacterial virulence factors during infection [PDF]
, 2016 Legionella pneumophila, the causative agent of Legionnaire's disease, uses its type IV secretion system to translocate over 300 effector proteins into host cells.
Broncel, M +7 more
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A Sec-dependent effector, CLIBASIA_04425, contributes to virulence in ‘Candidatus Liberibater asiaticus’ [PDF]
, 2023 Citrus Huanglongbing (HLB) is the most destructive citrus disease worldwide, mainly caused by ‘Candidatus Liberibacter asiaticus’ (CLas). It encodes a large number of Sec-dependent effectors that contribute to HLB progression.
Changyong Zhou +7 more
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A multi-phenotypic imaging screen to identify bacterial effectors by exogenous expression in a HeLa cell line [PDF]
, 2018 We present a high-content screen (HCS) for the simultaneous analysis of multiple phenotypes in HeLa cells expressing an autophagy reporter (mcherry-LC3) and one of 209 GFP-fused proteins from the Crohn’s Disease (CD)-associated bacterium, Adherent ...
A Collins +30 more
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Identification and Characterization of Legionella pneumophila Effector Proteins Important for in vivo Pathogenesis and Persistence [PDF]
, 2022 Legionella pneumophila is a natural pathogen of freshwater protozoa and an opportunistic pathogen of humans. Legionella is the causative agent of Legionnaires’ disease, a potentially fatal atypical pneumonia.
Liu, Luying
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A protein complex formed by Ustilago maydis effectors is essential for virulence [PDF]
, 2022 Ustilago maydis is a biotrophic fungal pathogen that causes smut disease in its host plant maize. During colonization, U. maydis secretes effector proteins to suppress plant defense responses and manipulate the host physiology for its own benefit.
Ludwig, Nicole
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