The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection [PDF]
, 2016 Coxiella burnetii, the etiological agent of Q fever in humans, is an intracellular pathogen that replicates in an acidified parasitophorous vacuole derived from host lysosomes.
Elizabeth Di Russo Case +10 more
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Identification and characterization of Brucella effector proteins [PDF]
, 2012 Brucella-bacteriën gebruiken de eiwitten VceB en VceC om het immuunsysteem van humane gastheercellen te omzeilen, blijkt uit het promotieonderzoek van Maarten de Jong.
de Jong, Maarten Frederik
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Population analysis of Legionella pneumophila epidemiology and the genetic basis for human pathogenicity [PDF]
, 2023 Legionella are globally ubiquitous aquatic bacteria that cause both Pontiac Fever (a mild flu) and Legionnaires' disease, a severe form of pneumonia with a 5-10% mortality rate.
Gorzynski, Jamie
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Capturing Legionella pneumophila effector enzymes using a ubiquitin derived photo-activatable probe [PDF]
Upon infection of host cells the Legionella pneumophila bacterium releases a multitude of effector enzymes into the host’s cytoplasm that manipulate cellular host pathways, including the host-ubiquitination pathways.
Kloet, M.S., Noort, G.J.V. van
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Insights into the role of legionella effectors on host metabolic perturbations [PDF]
Legionella infection, the causative agent of Legionnaires’ disease, represents a significant threat to human health. The pathogenesis of this infection is intricately linked to the complex interactions between the bacterium and its host, resulting in ...
Chunxiuli Li +5 more
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A random mutagenesis screen enriched for missense mutations in bacterial effector proteins [PDF]
To remodel their hosts and escape immune defenses, many pathogens rely on large arsenals of proteins (effectors) that are delivered to the host cell using dedicated translocation machinery.
Banh, Doreen +10 more
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Covalent probes to capture Legionella pneumophila dup effector enzymes [PDF]
Upon infection of host cells, Legionella pneumophila releases a multitude of effector enzymes into the cell's cytoplasm that hijack a plethora of cellular activities, including the host ubiquitination pathways. Effectors belonging to the SidE-family are
Dikic, I. +13 more
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Divergent evolution of di-lysine ER retention vs. farnesylation motif-mediated anchoring of the ankb virulence effector. [PDF]
, 2018 Legionella pneumophila is an aquatic organism capable of intracellular replication within a wide range of protozoan hosts and within human macrophages where it causes Legionnaires’ Disease. L.
Perpich, John David
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Brucella Modulation Of Host Secretory Membrane Compartments Via Multiple Type IV Effector Proteins [PDF]
Intracellular bacterial pathogens cause many infectious diseases of public health importance, where they modulate cellular functions during their lifecycle to promote essential virulence traits such as proliferation, dissemination, or persistence ...
Borghesan, Elizabeth
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The effect of amoeba predation on the evolution of virulence in human pathogenic microorganisms [PDF]
, 2023 Amoebae act as one of the main regulators of microbial communities, where, as a result of their predation, selection pressure is exerted for the emergence of defence mechanisms to achieve resistance.
Drncová, Eliška
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