Results 71 to 80 of about 170,938 (311)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A universal synthesis protocol for tuneable metal-organic framework nanohybrid

, 2022
Metal-organic frameworks (MOFs) with encapsulated functional nanoparticles (NPs) enjoy a vastly expanded application potential in catalysis, filtration, and sensing.
Nicola, Pinna, Michael, Bojdys, Wei, Zhang   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Selective capture of carbon dioxide from hydrocarbons using a metal-organic framework

Nature Communications, 2021
Metal-organic framework adsorbents are promising materials for gas separation and purification. Herein, the authors present a metal-organic framework that selectively captures CO2 over small hydrocarbons; this separation is relevant for the purification ...
Omid T. Qazvini, Ravichandar Babarao, Shane G. Telfer   +2 more
doaj   +1 more source

Retrofitting metal-organic frameworks [PDF]

Nature Communications, 2019
AbstractThe post-synthetic installation of linker molecules between open-metal sites (OMSs) and undercoordinated metal-nodes in a metal-organic framework (MOF) — retrofitting — has recently been discovered as a powerful tool to manipulate macroscopic properties such as the mechanical robustness and the thermal expansion behavior.
Christian Schneider, David Bodesheim, Julian Keupp, Rochus Schmid, Gregor Kieslich   +4 more
openaire   +3 more sources

Observation of an Intermediate to H2 Binding in a Metal–organic Framework

, 2021
Coordinatively-unsaturated metal sites within certain zeolites and metal–organic frameworks can strongly adsorb various molecules. While many classical examples involve electron-poor metal cations that interact with adsorbates largely through ...
Thomas, Gennett, Jeffrey A., Reimer, Jeffrey R., Long, Walter S., Drisdell, Craig M., Brown, Brandon R., Barnett, Jonas, Börgel, Romit, Chakraborty, Benjamin A., Trump, Lena M., Funke, Madison, Martinez, Gregory M., Su, Stephen A., FitzGerald, Tyler, Hartman, Matthew, Dods, Katherine, Hurst, Jacob, Tarver, Henry Z. H., Jiang, Hayden A., Evans, Martin, Head-Gordon, Didier, Banyeretse   +20 more
core   +1 more source

Metal–Organic Framework-Based Photodetectors

Nano-Micro Letters
Highlights The methods of preparing metal–organic framework (MOF)-based photodetectors and various types of MOFs are introduced. The applications of MOF photodetectors in the detection of X-ray, ultraviolet, and infrared radiation, biosensing, and ...
Jin-Biao Zhang, Yi-Bo Tian, Zhi-Gang Gu, Jian Zhang   +3 more
doaj   +1 more source

Synthesis and characterization of ZnBTC-based MOFs: effect of solvents and salt

Chimica Techno Acta, 2022
In this work, we studied the optimization of synthetic approaches to creating structurally modified metal-organic frameworks under various synthesis conditions.
Maria V. Timofeeva, Andrey N. Yankin
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source