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Metal ion homeostasis and intracellular parasitism
Molecular Microbiology, 1998Bacteria possess multiple mechanisms for the transport of metal ions. While many of these systems may have evolved in the first instance to resist the detrimental effects of toxic environmental heavy metals, they have since become adapted to a variety of important homeostatic functions.
D D, Agranoff, S, Krishna
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Essential transition metal homeostasis in plants
Current Opinion in Plant Biology, 2009The homeostasis of the essential transition metals copper, iron, manganese and zinc requires balanced activities of transporters that mediate import into the cell, distribution to organelles and export from the cell. Transcriptional control is important for the regulation of cellular homeostasis.
Pilon, Marinus +4 more
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Modulation of Metal Homeostasis for Cancer Therapy
ChemPlusChemAbstractMetal ions such as iron, zinc, copper, manganese, and calcium are essential for normal cellular processes, including DNA synthesis, enzyme activity, cellular signaling, and oxidative stress regulation. When the balance of metal homeostasis is disrupted, it can lead to various pathological conditions, including cancer.
Ying Yang, Huanhuan Fan, Zijian Guo
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Metal Acquisition and Homeostasis in Fungi
Current Fungal Infection Reports, 2012Transition metals, particularly iron, zinc and copper, have multiple biological roles and are essential elements in biological processes. Among other micronutrients, these metals are frequently available to cells in only limited amounts, thus organisms have evolved highly regulated mechanisms to cope and to compete with their scarcity.
Elisa Flávia Luiz Cardoso Bailão +11 more
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Bacterial Transition Metal Homeostasis
2007Since details on metal cation transport proteins and on the allocation mechanisms for transition metals are provided elsewhere in this book, I will present aspects of transition metal homeostasis in a hopefully novel overview. We will start with a microbial look at the transition metal Periodic Table, cation speciation, and availability in the ...
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Metal trafficking: from maintaining the metal homeostasis to future drug design
Metallomics, 2009The diverse proteins and enzymes involved in metal trafficking between and inside human cells form numerous transport networks which are highly specific for each essential metal ion and apoprotein. Individual players include voltage-gated ion channels, import and export proteins, intracellular metal-ion sensors, storage proteins and chaperones.
Lalla Aicha, Ba +3 more
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Selective Metal Ion Homeostasis in Cyanobacteria
2017Metal homeostasis systems are responsible for the uptake and efflux of both essential and non-essential metals. The capacity of these systems to acquire a particular metal, whilst excluding another is essential for the survival of not just cyanobacteria, but all organisms.
Lee Hudek, M. Leigh Ackland
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Transition metals homeostasis in Staphylococcus aureus
2019Staphylococcus aureus is a public health concern. It can evade the immune system and develop resistance to many antibiotic classes. The human immune system employs diverse mechanisms to overcome S. aureus infections including disrupting iron (Fe) and copper (Cu) homeostasis at the host-pathogen interface. The work presented herein described iron-sulfur
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Fungal–Metal Interactions: A Review of Toxicity and Homeostasis
Journal of Fungi (Basel, Switzerland), 2021Omoanghe S Isikhuemhen
exaly

