Results 41 to 50 of about 383,708 (316)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Development of Ionophore-Selective Based optical chemical sensors for the determination of heavy metal ions in aqueous environments [PDF]
, 2010 The development of optical sensors for in-situ, real-time and low-cost monitoring of heavy metal ions is a tremendously and fast growing area of research.
Li, Li
core
Metal–DNA interactions: Exploring the impact of metal ions on key stages of forensic DNA analysis
, 2023 Forensic DNA analysis continues to be hampered by the complex interactions between metals and DNA. Metal ions may cause direct DNA damage, inhibit DNA extraction and polymerase chain reaction (PCR) amplification or both.
Dan Nana Osei Bonsu +9 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Metal ions as matchmakers for proteins [PDF]
Proceedings of the National Academy of Sciences, 2010 Matchmakers have been shown to be valuable for single men and women in both ancient and modern societies. Matchmakers bring together two people who otherwise have little chance of being associated with each other, nurture the closeness between the two parties by enhancing their commonality and smoothing out their differences, and then quietly disappear
openaire +2 more sources
, 2020 Transition metal ions in coordination compounds can adopt different oxidation states. The Bond Valence Sum (BVS) model, based solely on structural information, relates the bond lengths around a metal center to its oxidation state.
Tu, Nguyen
core +1 more source
Removal of Heavy Metal Ions Using the Fungus
Adsorption Science & Technology, 2003 The potential use of the fungus Penicillium canescens for the removal of cadmium, lead, mercury and arsenic ions from aqueous solutions was evaluated in this study. Equilibrium biosorption of the heavy metal ions was attained in 4 h. The binding of heavy
Ridvan Say, Nalan Yilmaz, Adil Denizli
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source