Results 31 to 40 of about 305,977 (299)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Insights into the influence of Ni4Ti3 precipitates and martensite transformation on the glide of a[100] dislocation in austenitic NiTi alloys: an atomistic simulation study

Journal of Materials Research and Technology, 2023
Dislocation-dominated plastic deformation in austenitic NiTi alloys is highly detrimental and it could be suppressed by precipitation of Ni4Ti3. Additionally, at a certain temperature range, not only Ni4Ti3 precipitate but also the B19’ martensite ...
Zhu Li, Fei Xiao, Shungui Zuo, Ying Zhou, Xiaorong Cai, Xuejun Jin   +5 more
doaj   +1 more source

Advanced fiber-composite hybrids--A new structural material [PDF]

, 1974
Introduction of metal foil as part of matrix and fiber composite, or ""sandwich'', improves strength and stiffness for multidirectional loading, improves resistance to cyclic loading, and improves impact and erosion resistance of resultant fiber ...
Chamis, C. C., Lark, R. F., Sullivan, T. L.   +2 more
core   +1 more source

Review of progress on fabrication technology of Mg matrix composites

Journal of Magnesium and Alloys
Mg matrix composites (MgMCs) with enhanced mechanical and functional properties, as well as improved elastic modulus, have aroused rising attention from the aerospace, new energy vehicles, and consumer electronics industries.
Chenyang Jiang, Lidong Gu, Hongwei Xiong, Jingya Wang, Liping Zhou, Mingjie Shen, Jie Wang, Tao Ying, Xiaoqin Zeng   +8 more
doaj   +1 more source

Tensile properties of high strength cast Mg alloys at room temperature: A review [PDF]

China Foundry, 2014
As most Mg alloy products are now produced by a casting process, the development of high strength cast Mg alloys can promote their further applications and has already become one of the hot research areas of Mg alloys.
Fu Penghuai, Peng Liming, Jiang Haiyan
doaj  

Manufacturing of Composites by Pressure Infiltration, Structure and Mechanical Properties [PDF]

, 2008
This paper presents the possibility of composite block production by using pressure infiltration technology. This method uses the pressure of an inert gas (usually argon or nitrogen) to force the melted matrix material to infiltrate the reinforcing ...
Dobránszky, János, Németh, Árpád, Orbulov, Imre Norbert   +2 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source