Results 171 to 180 of about 7,747 (222)
Quantitative analysis of a metalloprotein compositional stoichiometry with PIXE and PESA
An absolute measurement of the heavy element concentrations in a dried sample of aqueous protein solution has been combined with the absolute measurement of protein molecular concentration in the same sample.
P A Deyoung, G F Peaslee
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Inorganic Chemistry, 2004
One of the most intriguing problems in the biological sciences is the question of how to predict protein structure and function based on knowledge of a gene sequence. While significant progress has been made toward this goal during the past decade, fundamental challenges remain, such as understanding important post-translational modifications.
Bren, Kara L. +2 more
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One of the most intriguing problems in the biological sciences is the question of how to predict protein structure and function based on knowledge of a gene sequence. While significant progress has been made toward this goal during the past decade, fundamental challenges remain, such as understanding important post-translational modifications.
Bren, Kara L. +2 more
openaire +3 more sources
2013
Paramagnetic metalloproteins are proteins containing one or more paramagnetic metal ions, which are characterized by the presence of at least one unpaired electron. As in every molecule, unpaired electrons sizably perturb the NMR parameters relative to the protein nuclei, changing their relaxation, chemical shift, and motional averaging so that ...
BERTINI, IVANO, PARIGI, GIACOMO
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Paramagnetic metalloproteins are proteins containing one or more paramagnetic metal ions, which are characterized by the presence of at least one unpaired electron. As in every molecule, unpaired electrons sizably perturb the NMR parameters relative to the protein nuclei, changing their relaxation, chemical shift, and motional averaging so that ...
BERTINI, IVANO, PARIGI, GIACOMO
openaire +2 more sources
Current Opinion in Biotechnology, 1996
The rational design of novel proteins offers a new method of studying structure and function, and makes possible the construction of new biomaterials. The richness of metal chemistry, the relative ease of creating stable complexes, and the remarkable degree of subtle, highly specific control of reactivity imposed by the protein matrix upon the metal ...
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The rational design of novel proteins offers a new method of studying structure and function, and makes possible the construction of new biomaterials. The richness of metal chemistry, the relative ease of creating stable complexes, and the remarkable degree of subtle, highly specific control of reactivity imposed by the protein matrix upon the metal ...
openaire +2 more sources
Predicting cracks in metalloproteins
Nature Machine Intelligence, 2019Loss-of-function mutations in metal-binding proteins are heavily implicated with numerous diseases, and identifying such ‘cracks’ will be valuable to biologists and medical doctors in the study and treatment of disease. A deep learning approach has been developed to tackle this challenging task.
Yuan Liu, Chu Wang
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Metalloproteins in the evolution of photosynthesis
Biosystems, 1981Certain metalloproteins are common to all photosynthetic electron transfer chains. These include soluble proteins such as ferredoxins and cytochromes of the c2 type, and membrane-bound components such as cytochrome b, c1 and the Rieske iron-sulphur protein.
R, Cammack, K K, Rao, D O, Hall
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Computational Design of Metalloproteins
2014A number of design strategies exist for the development of novel metalloproteins. These strategies often exploit the inherent symmetry of metal coordination and local topology. Computational design of metal binding sites in flexible regions of proteins is challenging as the number of conformational degrees of freedom is significantly increased ...
Avanish S, Parmar +2 more
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Metalloproteins and metal sensing
Nature, 2009Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells.
Kevin J, Waldron +3 more
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A supramolecular assembly enables discrimination between metalloproteins and non-metalloproteins
Chemical Communications, 2018A supramolecular assembly yields turn-on fluorescence response for non-metalloproteins and turn-off response for metalloproteins.
Aafrin M, Pettiwala, Prabhat K, Singh
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Metalloproteins and neuronal death
Metallomics, 2010Neurodegenerative diseases include Alzheimer's and Parkinson's disease that are very common and other diseases that are notorious but occur less often such as Creutzfeldt-Jakob disease. In each case a protein is closely linked to the pathology of these diseases. These proteins include alpha-synuclein, the prion protein and Aβ.
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