Results 171 to 180 of about 7,747 (222)

Quantitative analysis of a metalloprotein compositional stoichiometry with PIXE and PESA

open access: yesNuclear Instruments & Methods in Physics Research B, 2010
An absolute measurement of the heavy element concentrations in a dried sample of aqueous protein solution has been combined with the absolute measurement of protein molecular concentration in the same sample.
P A Deyoung, G F Peaslee
exaly   +2 more sources

Metalloprotein Folding

Inorganic Chemistry, 2004
One of the most intriguing problems in the biological sciences is the question of how to predict protein structure and function based on knowledge of a gene sequence. While significant progress has been made toward this goal during the past decade, fundamental challenges remain, such as understanding important post-translational modifications.
Bren, Kara L.   +2 more
openaire   +3 more sources

Paramagnetic Metalloproteins

2013
Paramagnetic metalloproteins are proteins containing one or more paramagnetic metal ions, which are characterized by the presence of at least one unpaired electron. As in every molecule, unpaired electrons sizably perturb the NMR parameters relative to the protein nuclei, changing their relaxation, chemical shift, and motional averaging so that ...
BERTINI, IVANO, PARIGI, GIACOMO
openaire   +2 more sources

Metalloprotein design

Current Opinion in Biotechnology, 1996
The rational design of novel proteins offers a new method of studying structure and function, and makes possible the construction of new biomaterials. The richness of metal chemistry, the relative ease of creating stable complexes, and the remarkable degree of subtle, highly specific control of reactivity imposed by the protein matrix upon the metal ...
openaire   +2 more sources

Predicting cracks in metalloproteins

Nature Machine Intelligence, 2019
Loss-of-function mutations in metal-binding proteins are heavily implicated with numerous diseases, and identifying such ‘cracks’ will be valuable to biologists and medical doctors in the study and treatment of disease. A deep learning approach has been developed to tackle this challenging task.
Yuan Liu, Chu Wang
openaire   +1 more source

Metalloproteins in the evolution of photosynthesis

Biosystems, 1981
Certain metalloproteins are common to all photosynthetic electron transfer chains. These include soluble proteins such as ferredoxins and cytochromes of the c2 type, and membrane-bound components such as cytochrome b, c1 and the Rieske iron-sulphur protein.
R, Cammack, K K, Rao, D O, Hall
openaire   +2 more sources

Computational Design of Metalloproteins

2014
A number of design strategies exist for the development of novel metalloproteins. These strategies often exploit the inherent symmetry of metal coordination and local topology. Computational design of metal binding sites in flexible regions of proteins is challenging as the number of conformational degrees of freedom is significantly increased ...
Avanish S, Parmar   +2 more
openaire   +2 more sources

Metalloproteins and metal sensing

Nature, 2009
Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells.
Kevin J, Waldron   +3 more
openaire   +2 more sources

A supramolecular assembly enables discrimination between metalloproteins and non-metalloproteins

Chemical Communications, 2018
A supramolecular assembly yields turn-on fluorescence response for non-metalloproteins and turn-off response for metalloproteins.
Aafrin M, Pettiwala, Prabhat K, Singh
openaire   +2 more sources

Metalloproteins and neuronal death

Metallomics, 2010
Neurodegenerative diseases include Alzheimer's and Parkinson's disease that are very common and other diseases that are notorious but occur less often such as Creutzfeldt-Jakob disease. In each case a protein is closely linked to the pathology of these diseases. These proteins include alpha-synuclein, the prion protein and Aβ.
openaire   +2 more sources

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