Results 101 to 110 of about 1,359,097 (217)

Genomic Profiling of Advanced-Stage, Metaplastic Breast Carcinoma by Next-Generation Sequencing Reveals Frequent, Targetable Genomic Abnormalities and Potential New Treatment Options [PDF]

, 2015
Context.— Metastatic metaplastic breast carcinoma (MPBC) is an uncommon, but aggressive, tumor resistant to conventional chemotherapy. Objective.— To learn whether next-generation sequencing could identify potential targets of therapy for patients ...
Ali, Siraj, Badve, Sunil, Boguniewicz, Ann B., Chliemlecki, Juliann, Elvin, Julia A., Lipson, Doron, Miller, Vincent A., Morosini, Deborah, Otto, Geoff A., Ross, Jeffrey S., Sheehan, Christine E., Stephens, Philip J., Wang, Kai, Yelensky, Roman   +13 more
core   +1 more source

Clinicopathological Diagnosis and Prognosis of Endometrioid Borderline Ovarian Tumors: Dual Case Reports and Literature Review

Cancer Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Introduction Endometrioid borderline ovarian tumor (EBOT) is rare and frequently misdiagnosed. This study aims to investigate the clinicopathological features, immunohistochemical characteristics, differential diagnosis, therapeutic approaches and disease prognosis, thereby establishing a robust foundation to mitigate misdiagnosis risks and ...
Fang Yang, Dong Chen, Qian Sun, Jingjing Yu, Xue Wang   +4 more
wiley   +1 more source

Rare breast cancer subtypes: Histological, molecular, and clinical peculiarities [PDF]

, 2014
Breast cancer encompasses a collection of different diseases characterized by different biological and pathological features, clinical presentation, response to treatments, clinical behavior, and outcome.
Conte, Pierfranco, Dieci, Maria Vittoria, Dominici, Massimo, Guarneri, Valentina, Orvieto, Enrico   +4 more
core   +1 more source

A Role for High Mobility Group Box 1 (HMGB1) Release in the Pathogenesis of Gastroesophageal Reflux Disease

Neurogastroenterology &Motility, Volume 37, Issue 11, November 2025.
Incubation of esophageal epithelial cells with a weakly acidic (pH 5) bile salt (deoxycholic acid) induces translocation of HMGB1 from the nucleus to the cytosol, and its subsequent release from the cell. This process can be ameliorated by pre‐treatment with the antioxidant, curcumin.
Tom Leech, David Kelsell, Diana Blaydon, Philip Woodland, Madusha Peiris   +4 more
wiley   +1 more source

Clinical significance of VEGF-A, -C and -D expression in esophageal malignancies [PDF]

, 2005
Vascular endothelial growth factors ( VEGF)- A, - C and - D are members of the proangiogenic VEGF family of glycoproteins. VEGF-A is known to be the most important angiogenic factor under physiological and pathological conditions, while VEGF-C and VEGF-D
Ahn MJ, Baatar D, Banks RE, Berse B, Boucher Y, Coia LR, Dirix LY, Du JR, Gu ZP, Guo WZ, Hefler L, Hickey K, Hironaka S, Isaka N, Ishikawa M, Karpanen T, Kato H, Kitadai Y, Kitamura K, Koide N, Koukourakis MI, Kukk E, Kumar H, Lackey VL, Lewis CE, Li Z, Maniwa Y, Millikan KW, Mobius C, Nagata J, Nguyen M, Noguchi T, Nor JE, Ohtsu A, Roberts WG, Rockwell S, Roder JD, Salven P, Shih CH, Spence GM, Suit HD, Theunissen PH, Uchida S, Vogel SB, Wallner G, Weingartner K, Yamamoto Y, Yang B, Yeo KT   +48 more
core   +1 more source

Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

Advanced Science, Volume 12, Issue 40, October 27, 2025.
Diagram of the reprogramming of FA metabolism mediated by LDHC4‐induced ACAA2 activity to promote TNBC progression. LDHC4 drives TNBC progression by enhancing ACAA2‐mediated fatty acid production. The resulting accumulation of FFAs stimulates autophagy and accelerates cell cycle progression, thereby promoting tumor growth.
Zhaolei Cui, Chaoqiang Zheng, Yingying Lin, Zhenzhou Xiao, Yanhong Li, Wei Peng, Shijie He, Anyang Li, Xiufeng Wu, Yan Chen, Yang Sun   +10 more
wiley   +1 more source

Response to Dabrafenib and Trametinib of a Patient with Metaplastic Breast Carcinoma Harboring a BRAF V600E Mutation

Case Reports in Oncological Medicine, 2020
Background Metaplastic breast carcinomas are rare and carry poor prognoses. They are also more aggressive than other breast cancers and are known for their resistance to chemotherapy.
T. Seo, E. Noguchi, Masayuki Yoshida, Taisuke Mori, M. Tanioka, K. Sudo, A. Shimomura, K. Yonemori, Y. Fujiwara, K. Tamura   +9 more
semanticscholar   +1 more source

A Case of Squamous Cell Carcinoma Arising From an Intraductal Papilloma of the Breast

Clinical Case Reports, Volume 13, Issue 10, October 2025.
Graphical abstract showing squamous cell carcinoma arising from an intraductal papilloma of the breast. ABSTRACT We present a rare case of squamous cell carcinoma arising from an intraductal papilloma in a 60‐year‐old female. Histopathology revealed an invasive squamous cell carcinoma with p63 positivity, coexisting with a benign papilloma.
Kanako Nishiyama, Kumiko Okujima, Yosuke Mizuno   +2 more
wiley   +1 more source

Metaplastic carcinoma of the breast: A diagnostic dilemma

Saudi Journal of Medicine and Medical Sciences, 2015
Metaplastic carcinomas of the breast are malignant neoplasms composed of a mixture of epithelial and mesenchymal elements. They are rare with incidence of lesser than 1% of invasive breast carcinoma.
Vani B Ramalingiah, Geethamala Kempula, Panduranga Chikkannaiah, Srinivasamurthy Venkataramappa   +3 more
doaj   +1 more source

miR-139-5p is a regulator of metastatic pathways in breast cancer [PDF]

, 2013
Metastasis is a complex, multistep process involved in the progression of cancer from a localized primary tissue to distant sites, often characteristic of the more aggressive forms of this disease.
Cloonan, Nicole, Grimmond, Sean M., Krishnan, Keerthana, Lakhani, Sunil R., Mariasegaram, Mythily, Martin, Hilary, Nones, Katia, Pattabiraman, Diwakar R., Simpson, Peter T., Steptoe, Anita, Vlassov, Alexander, Waddell, Nicola   +11 more
core   +2 more sources