Results 141 to 150 of about 1,018,202 (279)

Temporal trends and predictors of inpatient palliative care in metastatic upper urinary tract carcinoma: An observational study. [PDF]

Palliat Care Soc Pract
Siech C, Scheipner L, Baudo A, de Angelis M, Jannello LMI, Di Bello F, Saad F, Shariat SF, Longo N, Carmignani L, de Cobelli O, Ahyai S, Briganti A, Cano Garcia C, Kluth LA, Chun FKH, Karakiewicz PI.   +16 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Perioperative risk stratification after resection of brain metastases: internal development and validation of the dominant lesion surgery score in a 20-year single-center cohort. [PDF]

J Neurooncol
Aydın HA, Keskin E, Kalaycı M.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Evaluation of RECIST v1.1 for predicting overall survival in sarcoma patients with pulmonary metastasis. [PDF]

Cancer Imaging
Gold L, Klambauer K, Dascalescu C, Klinge L, Winkelmann M, Mansour N, Mehrens D, Ricke J, von Bergwelt-Baildon M, Di Gioia D, Lindner LH, Kunz WG.   +11 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Metastatic Colorectal Cancer as a Chronic Disease: Twelve-Year Survival After Initially Unresectable Bilobar Liver Metastases. [PDF]

Cureus
Mathew T, Smith S, George M.
europepmc   +1 more source

Combined ablation and radiation therapy of spinal metastases: A novel multimodality treatment approach [PDF]

, 2015
Friedman, Michael V, Greenwood, Taylor J, Hillen, Travis J, Jennings, Jack W, Robinson, Clifford G, Wallace, Adam   +5 more
core   +1 more source

Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: early analysis of a non-randomised, open-label, phase 2 trial.

The Lancet Oncology, 2016
S. Goldberg, S. Gettinger, A. Mahajan, A. Chiang, R. Herbst, M. Sznol, A. Tsiouris, J. Cohen, A. Vortmeyer, Lucia B. Jilaveanu, James B. Yu, U. Hegde, Stephanie Speaker, Matthew Madura, A. Ralabate, A. Rivera, E. Rowen, H. Gerrish, Xiaopan Yao, V. Chiang, H. Kluger   +20 more
semanticscholar   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source