Results 121 to 130 of about 134,430 (328)

Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasis

Molecular Cancer, 2010
Background Transforming Growth Factor β (TGF-β) plays an important role in tumor invasion and metastasis. We set out to investigate the possible clinical utility of TGF-β antagonists in a human metastatic basal-like breast cancer model.
Biswas Swati, McPherson John, Yingling Jonathan M, Lonning Scott, Kang Yibin, Banach-Petrosky Whitney, Xie Wen, Grazioli Alison, Ge Rongrong, Ganapathy Vidya, Mundy Gregory R, Reiss Michael   +11 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Genética molecular aplicada ao câncer cutâneo não melanoma Molecular genetics of non-melanoma skin cancer

Anais Brasileiros de Dermatologia, 2006
Os cânceres cutâneos não melanoma são as neoplasias malignas mais comuns em humanos. O carcinoma basocelular e o carcinoma espinocelular representam cerca de 95% dos cânceres cutâneos não melanoma, o que os torna um crescente problema para a saúde p ...
Marcos Antonio Rodrigues Martinez, Guilherme Francisco, Luciana Sanches Cabral, Itamar Romano Garcia Ruiz, Cyro Festa Neto   +4 more
doaj   +1 more source

Molecular Subtypes Based on Genomic and Transcriptomic Features Correlate with the Responsiveness to Immune Checkpoint Inhibitors in Metastatic Clear Cell Renal Cell Carcinoma [PDF]

, 2022
ByulA Jee, Eunjeong Seo, Kyunghee Park, Yi Rang Kim, Sun‐ju Byeon, Sang Min Lee, Jae Hoon Chung, Wan Song, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Se Hoon Park, Woong‐Yang Park, Minyong Kang   +16 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Wnt5a induces ROR1 to recruit cortactin to promote breast-cancer migration and metastasis. [PDF]

, 2019
ROR1 is a conserved oncoembryonic surface protein expressed in breast cancer. Here we report that ROR1 associates with cortactin in primary breast-cancer cells or in MCF7 transfected to express ROR1.
Briggs, Steven P, Hasan, Md Kamrul, Kipps, Thomas J, Lam, Sharon M, Parker, Barbara A, Shen, Zhouxin, Widhopf, George F, Zhang, Suping   +7 more
core   +1 more source

Two Different Cell Populations Is an Important Clue for Diagnosis of Primary Cutaneous Adenoid Cystic Carcinoma: Immunohistochemical Study

Case Reports in Pathology, 2017
Primary cutaneous adenoid cystic carcinoma (PCACC) is a very rare malignancy. The differential diagnosis of PCACCs in pathology practice can be difficult and a group of primary and metastatic lesions, including adenoid basal cell carcinoma of the skin ...
Banu Ince Alkan, Onder Bozdogan, Müjde Karadeniz, Nazan Bozdoğan   +3 more
doaj   +1 more source

Primary Basal Cell Carcinoma Masquerading as Metastatic Basal Cell Carcinoma in the Left Axilla. [PDF]

Cureus, 2023
Haskell Hanisch B, Frohm ML, Poling T.
europepmc   +1 more source

Data from Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab

, 2023
Ana‐Marija Grišić, Wenyuan Xiong, Lénaïg Tanneau, Siv Jönsson, Lena E. Friberg, Mats O. Karlsson, Haiqing Dai, Jenny Zheng, Pascal Girard, Akash Khandelwal   +9 more
openalex   +1 more source

Genomic Profiling of Metastatic Basal cell Carcinoma Reveals Candidate Drivers of Disease and Therapeutic Targets [PDF]

, 2023
Ismael A. Vergara, Karina Aivazian, Matteo S. Carlino, Alexander Guminski, Nigel G. Maher, Kerwin F. Shannon, Sydney Ch’ng, Robyn P.M. Saw, Georgina V. Long, James S. Wilmott, Richard A. Scolyer   +10 more
openalex   +1 more source