Results 61 to 70 of about 336,084 (346)

Sister Mary Joseph's Nodule at a University Teaching Hospital in Northwestern Tanzania: A Retrospective Review of 34 cases. [PDF]

, 2013
Sister Mary Joseph's nodule is a metastatic tumor deposit in the umbilicus and often represents advanced intra-abdominal malignancy with dismal prognosis. There is a paucity of published data on this subject in our setting.
A Dubreuil, AB Clements, AJ Khan, B Majmudar, B Piura, C Tam, D Calista, D Trebing, E Kolwijck, F Al-Mashat, F Panaro, FC Powell, H Bailey, H Bank, IS Schwartz, JJ Horn, JL O'Leary, Joseph B. Mabula, JP Touraud, M Falchi, M Yusuf, Mabula D. Mchembe, MR Shetty, MV Barrow, Peter F. Rambau, Phillipo L. Chalya, R Amaro, R Gabriele, R Gabriele, RA Shwartz, RS Goodheart, SN Chatterjee, V Charoenkul, V Schneider, VG Galva, WD Steck   +35 more
core   +1 more source

Patient with Gorlin syndrome and metastatic basal cell carcinoma refractory to smoothened inhibitors.

JAMA dermatology, 2014
IMPORTANCE Basal cell carcinomas (BCCs) in patients with Gorlin syndrome have been reported to be extremely sensitive to Smoothened (SMO) inhibitors, a novel targeted therapy against the Hedgehog pathway, because of characteristic mutations in these ...
G. Zhu, Angela S. Li, A. Chang
semanticscholar   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Nuclear β-arrestin1 is a critical cofactor of hypoxia-inducible factor-1α signaling in endothelin-1-induced ovarian tumor progression [PDF]

, 2016
Hypoxia-inducible factor-1α (HIF-1α) mediates the response to hypoxia or other stimuli, such as growth factors, including endothelin-1 (ET-1), to promote malignant progression in numerous tumors.
Bagnato, Anna, Caprara, Valentina, CIANFROCCA, Roberta, Di Castro, Valeriana, Rosanò, Laura, Sestito, Rosanna, TOCCI, PIERA   +6 more
core   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Loss of the tumor suppressor, Tp53, enhances the androgen receptor-mediated oncogenic transformation and tumor development in the mouse prostate. [PDF]

, 2019
Recent genome analysis of human prostate cancers demonstrated that both AR gene amplification and TP53 mutation are among the most frequently observed alterations in advanced prostate cancer. However, the biological role of these dual genetic alterations
Aldahl, Joseph, Cardiff, Robert D, Geradts, Joseph, He, Yongfeng, Hooker, Erika, Johnson, Daniel T, Kim, Won Kyung, Le, Vien, Lee, Dong-Hoon, Sun, Zijie, Wu, Huiqing, Yang, Julie S, Yoon, Junhee, You, Sungyong, Yu, Eun-Jeong   +14 more
core  

Triple negative breast cancer: new perspectives for targeted therapies [PDF]

, 2015
Breast cancer is a heterogeneous disease, encompassing a large number of entities showing different morphological features and having clinical behaviors.
Caruso, Davide, Frati, Luigi, Minozzi, Marina, Papa, Anselmo, Rossi, Luigi, Tomao, Federica, Tomao, Silverio, Vici, Patrizia, Zaccarelli, Eleonora   +8 more
core   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Risk of basal cell carcinoma after Hodgkin's disease [PDF]

, 2000
Background: Basal cell cancer is a common skin cancer, yet studies of second tumors after Hodgkin's disease tend to exclude basal cell cancers as second malignant tumors from analysis.
Aydemir, Ü., Grützner, S., Hiller, E., Hölzel, Dieter, Munker, Reinhold, Schmidt, M.   +5 more
core   +1 more source

Risk Factors and Prognosis for Metastatic Cutaneous Squamous Cell Carcinoma: A Cohort Study

Acta Dermato-Venereologica, 2020
Cutaneous squamous cell carcinoma (cSCC) has metastatic potential. The aims of this study were to identify the risk factors for metastasis of primary cSCC and for poor prognosis in metastatic cSCC. Retrospective primary tumour cohorts of metastatic cSCCs
Jaakko S. Knuutila, Pilvi Riihilä, Samu Kurki, Liisa Nissinen, Veli-Matti Kähäri   +4 more
doaj   +1 more source