Results 281 to 290 of about 302,269 (383)

Pharmacokinetic Characterization of Iopamidol and Iohexol for Optimizing Measured Glomerular Filtration Rate Assessment in Clinical Practice and Drug Development

The Journal of Clinical Pharmacology, EarlyView.
Abstract Accurate kidney function assessment supports healthcare and clinical decision‐making in practice and drug development. Measured glomerular filtration rate (mGFR) via iohexol clearance is the gold standard, but cost, supply issues, and logistical challenges limit its clinical use.
Levi Hooper, Michael Heung, Lu Wang, Aleksas Matvekas, Radin Alikhani, Michael T. Kenes, Kathleen A. Stringer, Bruce A. Mueller, Manjunath P. Pai   +8 more
wiley   +1 more source

Thapsigargin blocks relaxation of arterial smooth muscle by metformin [PDF]

, 2001
Jacob D. Peuler
openalex   +1 more source

Clinical Evaluation of Drug–Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P‐gp Pathways

The Journal of Clinical Pharmacology, EarlyView.
Abstract In addition to antiretroviral therapy (ART), people with HIV often take medications to treat comorbidities. It is therefore important to assess these medications for potential drug‐drug interactions, which may affect the safety and efficacy of ART. Three phase I studies were conducted in adult participants without HIV. The pharmacokinetics (PK)
Priyanka Arora, Hui Liu, John Ling, Jason T. Hindman, Dhananjay D. Marathe   +4 more
wiley   +1 more source

Metformin's Overall Effectiveness and Combined Action with Lifestyle Interventions in Preventing Type-2 Diabetes Mellitus in High-Risk Metformin-Naïve Patients: An Updated Systematic Review and Meta-Analysis of Published RCTs. [PDF]

J Clin Med
Tsironikos GI, Tsolaki V, Zakynthinos GE, Rammou V, Kyprianidou D, Antonogiannis T, Zakynthinos E, Bargiota A.   +7 more
europepmc   +1 more source

Treating type 2 diabetes in youth:a depressing picture [PDF]

, 2012
Pearson, E R
core   +1 more source

The use of metformin (Siofora®) in patients with abdominal type of obesity

, 2000
И. И. Дедов, С А Бутрова, Б. П. Мищенко, Ф Х Дзгоева   +3 more
openalex   +1 more source

Chronic kidney disease in the primary care setting: A narrative review

Journal of General and Family Medicine, EarlyView.
Abstract Chronic kidney disease (CKD) is a growing public health concern globally, with primary care physicians (PCPs) playing a pivotal role in its early detection and management. This review explores the epidemiology, risk factors, screening strategies, and clinical manifestations of CKD within primary care settings.
Faryal Safdar, Ahsan Aslam
wiley   +1 more source

Prevalence of Vitamin B12 Deficiency in Type 2 Diabetic Patients on Long-Term Metformin Therapy. [PDF]

Cureus
Tayong FM, Francis TO, Kj J, Mahato RK, Ullah H, Kamal S, Kamil K.   +6 more
europepmc   +1 more source

Metformin reverses periodontal destruction caused by experimental periodontitis by inhibiting interleukin‐1β activity

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis is a destructive disease that affects periodontal tissue. While current research focuses on disease management, research on tissue repair remains limited. Metformin, a first‐line medication for diabetes treatment, has positive effects on bone health in nondiabetic patients.
Zhao Wang, Ju Han Song, Jung‐Woo Kim, Seung‐Hee Kwon, Xianyu Piao, Sin‐Hye Oh, Suk‐Gyun Park, Sun‐Hun Kim, Je‐Hwang Ryu, Ok‐Su Kim, Jeong‐Tae Koh   +10 more
wiley   +1 more source

Metformin use in gestational diabetes is not associated with an increased risk of preterm labor and small for gestational age infants compared to diet control alone. [PDF]

BMC Pregnancy Childbirth
D'Souza A, Abdullahi H, Badri F, Ibrahim I.   +3 more
europepmc   +1 more source