ABSTRACT Background In patients with diabetes, antenatal glucocorticoids can induce transient maternal hyperglycaemia for approximately 72 h. This may be associated with adverse outcomes, including neonatal hypoglycaemia, prompting recommendations for prophylactic increases in insulin by some expert groups; however, there are no validated protocols.
Annabel Jones +6 more
wiley +1 more source
SARS-CoV-2 spike protein causes synaptic dysfunction and p-tau and α-synuclein aggregation leading cognitive impairment: The protective role of metformin. [PDF]
Lee HK +5 more
europepmc +1 more source
Abstract Background There is growing interest in the relationship between sleep disorders and erectile dysfunction. We present the results from a 2015 follow‐up study in relation to the 2007 edition of Epidemiologic Sleep Study (EPISONO), a population‐based sleep study conducted in São Paulo, Brazil, and from the 4th edition of EPISONO (2018), with ...
Monica Levy Andersen +4 more
wiley +1 more source
Metformin for endothelial dysfunction in non-diabetic disorders: a scoping review. [PDF]
van Rensburg R +4 more
europepmc +1 more source
Exposure to gestational diabetes mellitus is associated with increased morbidity in children up to 12 years of age, defined by specialized health care utilization. The difference in morbidity between exposed and unexposed children is not limited to a certain age period but is present from early childhood to school age. Abstract Introduction Gestational
Jenni Kinnunen +8 more
wiley +1 more source
Prophylactic administration of metformin alleviates withdrawal symptoms associated with heroin. [PDF]
Liu M +10 more
europepmc +1 more source
In‐depth multiomics analyses revealed that the gut microbiota in patients with CPH is dysbiotic. Altered gut microbiota plays an important role in the progression of CPH and affects the host's arginine metabolism to promote arginine biosynthesis. The pro‐inflammatory effects of certain gut bacteria induce iNOS expression, which together act on the ...
Qun Zhang +15 more
wiley +1 more source
Metformin Impact on Maternal and Infant Cardiometabolic Health (MIMICH), an open-label randomised controlled trial, and Metformin Impact on Maternal and Cardiometabolic Health After Pregnancy (MIMICH II). [PDF]
Amica-Carpenter A +7 more
europepmc +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Are metformin-based combination approaches beneficial for non-small cell lung cancer: evidence from experimental and clinical studies. [PDF]
Thyagarajan A, Gajjar V, Sahu RP.
europepmc +1 more source

