Results 131 to 140 of about 3,643,521 (182)

The Impact of High-Fructose Diet and Co-Sensitization to House Dust Mites and Ragweed Pollen on the Modulation of Airway Reactivity and Serum Biomarkers in Rats. [PDF]

Int J Mol Sci
Zimbru RI, Zimbru EL, Ordodi VL, Bojin FM, Crîsnic D, Grijincu M, Mirica SN, Tănasie G, Georgescu M, Huțu I, Haidar L, Păunescu V, Panaitescu C.   +12 more
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Precision Medicine for Asthma: Tailored to its Severity and Endotype/Phenotype. [PDF]

Allergy Asthma Immunol Res
Chan R, Horn NE, Siddiqui S.
europepmc   +1 more source

Vasicine Attenuates Allergic Asthma by Suppressing Mast Cell Degranulation and Th2 Inflammation via Modulation of the FcεRI/Lyn + Syk/MAPK Pathway. [PDF]

Pharmaceuticals (Basel)
Qu L, Du W, Ren Z, Chen M, Wu X, Cao X, Rao G, Tong X, Huang F, Sun Y.   +9 more
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Identification of Environmental Compounds That May Trigger Early Female Puberty by Activating Human GnRHR and KISS1R.

Endocrinology
Yang S, Zhang L, Khan K, Travers J, Huang R, Jovanovic VM, Veeramachaneni R, Sakamuru S, Tristan CA, Davis EE, Klumpp-Thomas C, Witt KL, Simeonov A, Shaw ND, Xia M.   +14 more
europepmc   +1 more source

Effects of <i>Nigella sativa</i> and its constituents on total white blood cells count and airway responsiveness value in ovalbumin-induced asthma models: A preclinical systematic review and meta-analysis. [PDF]

Avicenna J Phytomed
Mohammadzadeh E, Ghobadi H, Mohammadshahi J, Aslani F, Boskabady MH, Aslani MR.   +5 more
europepmc   +1 more source

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Design, Synthesis, and Biological Evaluation of Novel Spiro Imidazobenzodiazepines to Identify Improved Inhaled Bronchodilators.

Journal of Medicinal Chemistry, 2023
Novel gamma-aminobutyric acid receptor (GABAAR) ligands structurally related to imidazobenzodiazepine MIDD0301 were synthesized using spiro-amino acid N-carboxyanhydrides (NCAs). These compounds demonstrated increased resistance to phase 2 metabolism and
Daniel A. Webb, Michelle J Meyer, Kayode M Medubi, Anika S Tylek, G. Yocum, M. Roni, Nicolas M. Zahn, Sarah A Swartwout, Ahmad K Masoud, C. Emala, D. Stafford, L. Arnold   +11 more
semanticscholar   +1 more source

Inula japonica Thunb. and its active compounds ameliorate airway inflammation by suppressing JAK-STAT signaling.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Asthma, a chronic inflammatory disease, remains a global health challenge due to its complex pathophysiology and the limited treatment efficacy. This study explored the effect of Inula japonica Thunb.
Myung-Ah Jung, Joo Young Lee, Y. Kim, Kon-Young Ji, M. Le, Dong Ho Jung, Yun Hee Kim, Wook Jin Kim, Byeong Cheol Moon, Bu-Yeo Kim, Taesoo Kim   +10 more
semanticscholar   +1 more source

Protective effects and active ingredients of Salvia miltiorrhiza Bunge extracts on airway responsiveness, inflammation and remodeling in mice with ovalbumin-induced allergic asthma.

Phytomedicine, 2019
BACKGROUND Salvia miltiorrhiza Bunge (S. miltiorrhiza), a traditional Chinese medicine, has demonstrated antioxidant, anti-inflammatory, and antibacterial activities.
Junming Luo, Li Zhang, Xinyi Zhang, Y. Long, Fang Zou, Chunsong Yan, W. Zou   +6 more
semanticscholar   +1 more source

[The effect of an oral gold compound, auranofin, on bronchial responsiveness to inhaled methacholine in well-controlled bronchial asthma].

Arerugi = [Allergy], 1992
Recently, in Japan, auranofin (6 mg/day) has been demonstrated to be a useful treatment for patients with moderate to severe asthma in a double-blind clinical trial. Therefore, to investigate the mechanism of auranofin on bronchial asthma, we examined pulmonary functions and bronchial responsiveness to inhaled methacholine in well-controlled asthmatics
M, Honma, G, Tamura, Y, Taniguchi, T, Takishima   +3 more
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Cocaine inhibits muscarinic cholinergic receptors in heart and brain.

Journal of Pharmacology and Experimental Therapeutics, 1988
(-)-Cocaine inhibits M2 muscarinic cholinergic binding measured with [3H]quinuclidinyl benzilate in heart and brain with a Ki of 18.8 microM. The cyclic nucleotide 5'-guanylylimidodiphosphate does not shift the competition curve, suggesting that ...
J. Sharkey, M. C. Ritz, J. Schenden, R. Hanson, Michael J. Kuhar   +4 more
semanticscholar   +1 more source