Results 341 to 350 of about 121,985 (386)
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American Journal of Hospice and Palliative Medicine®, 2008
Methadone hydrochloride is an old drug that has been in vogue off and on. It has complex pharmacodynamics and can be potentially fatal in inexperienced settings. Drug switching from an opioid to methadone or vice versa requires knowledge of equianalgesic dosing.
Chhabra, Shalini, Bull, Janet
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Methadone hydrochloride is an old drug that has been in vogue off and on. It has complex pharmacodynamics and can be potentially fatal in inexperienced settings. Drug switching from an opioid to methadone or vice versa requires knowledge of equianalgesic dosing.
Chhabra, Shalini, Bull, Janet
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Journal Of Pain & Palliative Care Pharmacotherapy, 2005
Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence. The pharmacokinetics of methadone differ from those of morphine in that methadone has a higher bioavailability, a much longer half-life, and is hepatically metabolized by cytochrome P450 enzymes.
Kristin L. Satterfield +2 more
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Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence. The pharmacokinetics of methadone differ from those of morphine in that methadone has a higher bioavailability, a much longer half-life, and is hepatically metabolized by cytochrome P450 enzymes.
Kristin L. Satterfield +2 more
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The levels of methadone in the plasma in methadone maintenance
Clinical Pharmacology & Therapeutics, 1972The time course of methadone in the plasma of 5 methadone maintenance subjects receiving a single daily oral dose of 100 or 120 mg. has been determined. The predose mean plasma level of methadone was 0.48 fig per milliliter. The peak plasma level occurred at 4 hours with an average value of 0.86 fig per milliliter. This level slowly declined so that 24
Charles E. Inturrisi, Karl Verebely
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Diazepam and methadone interactions in methadone maintenance
Clinical Pharmacology and Therapeutics, 1984Survey study data and high rates of diazepam use/abuse in methadone maintenance suggest that acute administration of diazepam with daily methadone doses may enhance methadone effects. Acute subjective and physiologic effects of single oral doses of placebo, diazepam (20 and 40 mg), methadone (100%, 150%, and 200% of the maintenance dose), and four ...
George E. Bigelow +4 more
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Pediatrics, 1971 The increasing use of methadone maintenance (substitution) programs1-3 in the treatment of adult heroin addiction has created situations for children which require the attention of pediatricians. Methadone is an analgesic drug. In urban areas, thousands of heroin addicts are now receiving high dosage of methadone, usually 80 to 120 mg daily.
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JAMA: The Journal of the American Medical Association, 1978
To the Editor.— In the course of treating patients with severe pain, it is sometimes difficult to continue administering injections of narcotic analgesics over prolonged periods for various reasons. This is especially a problem in terminally ill patients who require higher-than-usual doses or more frequent drug administration than usual.
Alex A. Cardoni, J. Ken Walters
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To the Editor.— In the course of treating patients with severe pain, it is sometimes difficult to continue administering injections of narcotic analgesics over prolonged periods for various reasons. This is especially a problem in terminally ill patients who require higher-than-usual doses or more frequent drug administration than usual.
Alex A. Cardoni, J. Ken Walters
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BMJ, 2012
When I was young, I drank to get wrecked. In the hospitals in the 1980s and 1990s, I witnessed the complications of heroin addiction: amputations, gangrene, endocarditis, sepsis, hepatitis, and HIV. A stream of ambulances spilt half dead overdosers onto accident and emergency trolleys. There was no drug for opioid substitution—for example, methadone—so
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When I was young, I drank to get wrecked. In the hospitals in the 1980s and 1990s, I witnessed the complications of heroin addiction: amputations, gangrene, endocarditis, sepsis, hepatitis, and HIV. A stream of ambulances spilt half dead overdosers onto accident and emergency trolleys. There was no drug for opioid substitution—for example, methadone—so
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Methadone Maintenance: A Comparison of Methadone Treatment Subjects and Methadone Treatment Dropouts
International Journal of the Addictions, 1975Commonly agreed upon goals in conjunction with methadone maintenance have been (1) a return to legitimate employment, (2) cessation or substantial reduction in criminal behavior, (3) reduction in the amount of time spent in drug-seeking behavior, (4) involvement with a social system in which there is a positive reinforcement for relating to people, and
Williams Wv, Lee J
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Methadone—Disulfiram Interaction During Methadone Maintenance
The Journal of Clinical Pharmacology, 1980In an attempt to characterize a possible drug interaction between methadone and disulfiram, 500 mg/day insulfiram was administered orally for seven days to seven subjects on methadone maintenance. Plasma methadone concentrations and urinary excretion of methadone and its pyrrolidine and pyrrolidone metabolites were measured and subjective symptoms of ...
Theodore G. Tong +2 more
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Annals of the New York Academy of Sciences, 1976
We have demonstrated the dangers of alcoholism that complicate methadone treatment of heroin addiction. In future papers, we will attempt to identify contributory factors and suggest interventionist techniques. In the final analysis, however, rehabilitation programs, vocational programs, and, above all, alleviation of the dreadful socioeconomic ...
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We have demonstrated the dangers of alcoholism that complicate methadone treatment of heroin addiction. In future papers, we will attempt to identify contributory factors and suggest interventionist techniques. In the final analysis, however, rehabilitation programs, vocational programs, and, above all, alleviation of the dreadful socioeconomic ...
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