Results 271 to 280 of about 44,768 (313)
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Disposition of methadone in methadone maintenance
Clinical Pharmacology & Therapeutics, 1975Six detoxified opiate addicts housed in a closed metabolic ward received methadone in stepwise increasing doses of 10, 20, 40, and 80 mg/day during 1 month. Four were given 14C‐methadone at the lowest dose and again at the highest dose. Of the subjects receiving radiomethadone, 2 excreted the major part of the radioactivity in urine and 2 about equally
Robert E. McMahon +5 more
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Methadone Maintenance—Is it Enough?
International Journal of the Addictions, 1971Greenwich House Counseling Center is a psychiatric clinic providing outpatient treatment and services solely to drug addicts and their families. During its more than six year existence, the Counseling Center has made use of both individual and group treatment methods, supplemented by prescribed medication.
Thomas Connor, Eleanor Kremen
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JAMA: The Journal of the American Medical Association, 1972
To the Editor.— With one exception, I concur with the position taken by the AMA Council on Mental Health in their explication, "Oral Methadone Maintenance Techniques in the Management of Morphine—Type Dependence." That position perpetuates the impression that, in general, addicts must be maintained at a daily dose level of between 80 and 120 mg.
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To the Editor.— With one exception, I concur with the position taken by the AMA Council on Mental Health in their explication, "Oral Methadone Maintenance Techniques in the Management of Morphine—Type Dependence." That position perpetuates the impression that, in general, addicts must be maintained at a daily dose level of between 80 and 120 mg.
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Methadone Maintenance Withdrawal
JAMA: The Journal of the American Medical Association, 1972To the Editor.— The Sept 27 report on abrupt withdrawal of methadone maintenance by Lipkowitz et al ( 216 :1860, 1971) suggested that the withdrawal responses were primarily subjective rather than objective. Because of the potency and the increasing use of methadone, more clinical information about this substance is needed. We do not feel that abrupt
Alan D. Tice, Emil F. Pascarelli
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The levels of methadone in the plasma in methadone maintenance
Clinical Pharmacology & Therapeutics, 1972The time course of methadone in the plasma of 5 methadone maintenance subjects receiving a single daily oral dose of 100 or 120 mg. has been determined. The predose mean plasma level of methadone was 0.48 fig per milliliter. The peak plasma level occurred at 4 hours with an average value of 0.86 fig per milliliter. This level slowly declined so that 24
Charles E. Inturrisi, Karl Verebely
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Methadone Maintenance and Recovery
The American Journal of Drug and Alcohol Abuse, 1993(1993). Methadone Maintenance and Recovery. The American Journal of Drug and Alcohol Abuse: Vol. 19, No. 1, pp. 135-137.
Robert G. Newman +2 more
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Diazepam and methadone interactions in methadone maintenance
Clinical Pharmacology and Therapeutics, 1984Survey study data and high rates of diazepam use/abuse in methadone maintenance suggest that acute administration of diazepam with daily methadone doses may enhance methadone effects. Acute subjective and physiologic effects of single oral doses of placebo, diazepam (20 and 40 mg), methadone (100%, 150%, and 200% of the maintenance dose), and four ...
George E. Bigelow +4 more
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Methadone Maintenance and Amitriptyline
JAMA: The Journal of the American Medical Association, 1979To the Editor.— I read the article "Abuse of Amitriptyline" by Cohen et al (240:1372, 1978) and must concur with their conclusions that misuse and abuse of amitriptyline (Elavil) among drug-dependent patients are not uncommon. Through patient interviews and abuse patterns, it has been obvious for many years that an active "street market" has and does ...
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Methadone—Disulfiram Interaction During Methadone Maintenance
The Journal of Clinical Pharmacology, 1980In an attempt to characterize a possible drug interaction between methadone and disulfiram, 500 mg/day insulfiram was administered orally for seven days to seven subjects on methadone maintenance. Plasma methadone concentrations and urinary excretion of methadone and its pyrrolidine and pyrrolidone metabolites were measured and subjective symptoms of ...
Theodore G. Tong +2 more
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