Results 41 to 50 of about 6,898,244 (304)

Engineering the native methylotrophs for the bioconversion of methanol to value-added chemicals: current status and future perspectives

Green Chemical Engineering, 2023
Methanol is becoming an attractive fermentation feedstock for large-scale bioproduction of chemicals, due to its natural abundance and mature production technology. Native methylotrophs, which can utilize methanol as the only source of carbon and energy,
Jing Wang, Ruirui Qin, Yuanke Guo, Chen Ma, Xin Wang, Kequan Chen, Pingkai Ouyang   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Economic Analysis and Development Prospects of Green Methanol under the Background of Carbon Emission Reduction [PDF]

MATEC Web of Conferences
With increasing attention to climate issues, the development of green energy has become a growing focus. Green methanol, as a potential clean energy source, can not only significantly reduce carbon dioxide emissions but also utilize carbon dioxide as a ...
Chen Sirui
doaj   +1 more source

Thermo-Economic Analysis of Integrated Hydrogen, Methanol and Dimethyl Ether Production Using Water Electrolyzed Hydrogen

Resources, 2022
Carbon capture and utilization is an attractive technique to mitigate the damage to the environment. The aim of this study was to techno-economically investigate the hydrogenation of CO2 to methanol and then conversion of methanol to dimethyl ether using
Yusra Muazzam, Muhammad Yousaf, Muhammad Zaman, Ali Elkamel, Asif Mahmood, Muhammad Rizwan, Muhammad Adnan   +6 more
doaj   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Assessment of Green Methanol Production Potential and Related Economic and Environmental Benefits: The Case of China

Energies, 2020
Adopting a new paradigm for social development implies a transition to a circular economy. The above requires the reduction of greenhouse gas emissions, the utilization of wastes, and the use of renewable energy sources. The most promising way is the use
Oleg Bazaluk, Valerii Havrysh, Vitalii Nitsenko, Tomas Baležentis, Dalia Streimikiene, Elena A. Tarkhanova   +5 more
doaj   +1 more source

Engineering the methylotrophic yeast Ogataea polymorpha for lactate production from methanol

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Lactate has gained increasing attention as a platform chemical, particularly for the production of the bioplastic poly-lactic acid (PLA).
Katrin Wefelmeier, Simone Schmitz, Anna Maria Haut, Johannes Otten, Tobias Jülich, Lars Mathias Blank   +5 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Artificial Neural Network Surrogate Modelling for Predicting and Optimising CO2 Conversion to Methanol Under Uncertainty

CAAI Transactions on Intelligence Technology
This study introduces a data‐driven surrogate modelling framework that combines an artificial neural network (ANN) with particle swarm optimisation (PSO) and a genetic algorithm (GA) to optimise methanol production under uncertain conditions.
Muhammad Zulkefal, Iftikhar Ahmad, Hakan Caliskan, Hiki Hong, Farooq Ahmad   +4 more
doaj   +1 more source