Methicillin-resistant staphylococci [PDF]
Eighteen strains ofStaph. pyogenes(nine penicillin-sensitive and nine penicillin-destroying) were passaged 40 to 50 times on Celbenin1ditch plates.All strains developed an increase in resistance to Celbenin and eight strains (four penicillin-sensitive and four penicillin-destroying) were able to grow in 100 μg/ml. or more Celbenin.
Mary Barber
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PHARMACOLOGY OF METHICILLIN [PDF]
The pharmacology of a new antibiotic methicillin, 6(2:6‐dimethoxybenzamido)‐penicillanic acid, which is effective against staphylococci resistant to penicillin G, has been investigated. It is free from acute and chronic toxic effects, except that some pain may be caused following intramuscular injection.
D. Wright+3 more
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Methicillin Hemorrhagic Cystitis [PDF]
Interstitial nephritis is a recognized complication of methicillin therapy. Hemorrhagic cystitis due to methicillin has not been emphasized. Evidence of hemorrhagic cystitis developed in six patients receiving methicillin therapy and was confirmed by cystoscopy in three of them.
Charles V. Sanders+2 more
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The Effect of Methicillin on Skin Lesions in Guinea-Pigs Caused By "Methicillin-Sensitive" and "Methicillin-Resistant" Staphylococcus Aureus [PDF]
SUMMARY The therapeutic effect of methicillin on skin lesions in guinea-pigs produced by two strains of Staphylococcus aureus showing heterogeneous resistance to methicillin, and by two strains of normal sensitivity, was compared. Methicillin was given intravenously immediately after the intradermal inoculation of staphylococci and the skin lesions ...
J. H. Hewitt, P J Sanderson
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Methicillin-resistant staphylococci [PDF]
Strains of staphylococci resistant to methicillin were identified immediately after introduction of this drug. Methicillin-resistant strains have unusual properties, the most notable of which is extreme variability in expression of the resistance trait.
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PBP4: A New Perspective on Staphylococcus aureus β-Lactam Resistance. [PDF]
β-lactam antibiotics are excellent drugs for treatment of staphylococcal infections, due to their superior efficacy and safety compared to other drugs.
Chambers, Henry F+3 more
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Global distribution and diversity of ovine-associated Staphylococcus aureus [PDF]
Staphylococcus aureus is an important pathogen of many species, including sheep, and impacts on both human and animal health, animal welfare, and farm productivity. Here we present the widest global diversity study of ovine-associated S.
Aires-de-Sousa+55 more
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Staphylococcus aureus in the oral cavity: a three-year retrospective analysis of clinical laboratory data [PDF]
OBJECTIVE: A retrospective analysis of laboratory data to investigate the isolation of Staphylococcus aureus from the oral cavity and facial area in specimens submitted to a regional diagnostic oral microbiology laboratory.
A J Smith+24 more
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Genomic insights into the rapid emergence and evolution of MDR in Staphylococcus pseudintermedius. [PDF]
OBJECTIVES: MDR methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains have emerged rapidly as major canine pathogens and present serious treatment issues and concerns to public health due to their, albeit low, zoonotic potential. A further
A. J. McCarthy+31 more
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Hospital-acquired infection with methicillin-resistant and methicillin-sensitive staphylococci [PDF]
SUMMARYIn-patients at a London hospital over one year from whom the south-east England strain of ‘epidemic’ methicillin-resistant Staphylococcus aureus (MRSA) was isolated were compared with in-patients with strains of methicillin-sensitive Staphylococcus aureus (MSSA).
M. R. Law, O. N. Gill
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