Developmental Dynamics, EarlyView.Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez +4 more
wiley +1 more source
Expanding the Phenotypic Spectrum of Methylenetetrahydrofolate Reductase (MTHFR) Deficiency in Childhood: A Case Series. [PDF]
Clin Case RepLoftus E +7 more
europepmc +1 more source
Role of selenium in the pathophysiology of cardiorenal anaemia syndrome
ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai +2 more
wiley +1 more source
Methionine Restriction Attenuates Scar Formation in Fibroblasts Derived from Patients with Post-Burn Hypertrophic Scar. [PDF]
Int J Mol SciCui HS +6 more
europepmc +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
L-methionine promotes CD8<sup>+</sup> T cells killing hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling. [PDF]
NeoplasiaYuan C +8 more
europepmc +1 more source
DMAPO/Boc2O‐Mediated One‐Pot Direct N‐Acylation of Sulfoximines with Carboxylic Acids
European Journal of Organic Chemistry, Accepted Article.This report describes a general and simple method for the one‐pot direct N‐acylation of sulfoximines with carboxylic acids using our previously developed 4‐(N,N‐dimethylamino)pyridine N‐oxide (DMAPO)/di‐tert‐butyl dicarbonate (Boc2O) system. The method can be performed under mild low‐temperature reaction conditions and has a wide substrate scope.
Atsushi Umehara +2 more
wiley +1 more source
The Effect of Dietary Protein Restriction in Phase Feeding Systems on Nitrogen Metabolism and Excretion in Pig Production. [PDF]
Animals (Basel)Sobotka W, Drażbo A.
europepmc +1 more source
Postulations for the Migration Behavior of Amino Acids as Cations in Capillary Zone Electrophoresis
ELECTROPHORESIS, EarlyView.ABSTRACT Amino acids (AAs) in their cationic form at pH 2.2 and usual ionic strength show a non‐intuitive migration order in CZE. This is explained by setting up four postulates. The central points in these postulates are the influence of the AA side chain on the pKa${\rm p}K_{\rm a}$ value and the adoption of a defined, preferred conformation to build
Peter Gross +5 more
wiley +1 more source