Results 71 to 80 of about 18,939,161 (298)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
ComputersIn recent years, the increasing complexity of production systems driven by technological development has created new opportunities in the industrial world but has also brought challenges in the practical use of these systems by operators.
Annalisa Bertoli, Cesare Fantuzzi
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Simple and Rapid Device for Mercury Detection Based on The Formation of Mercury(II)-Dithizonate on Polytetrafluoroethylene (PTFE) Membrane [PDF]
Journal of Pure and Applied Chemistry Research, 2019 A new analytical device for mercury detection has been developed by doping dithizone on to hydrophobic PTFE (polytetrafluoroethylene) membrane to form a blue dithizone membrane which instantaneously changed to orange color of mercury(II)-dithizonate ...
Hermin Sulistyarti +4 more
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Publication bias is bad for science if not necessarily scientists
Royal Society Open ScienceIt might seem obvious that the scientific process should not be biased. We strive for reliable inference, and systematically skewing the results of inquiry apparently conflicts with this.
Remco Heesen, Liam Kofi Bright
doaj +1 more source
Johanna Claasen of the Most Secret Method, Black Cat, Washington, D.C., March 13, 1997
, 1997 Photograph of Johanna Claasen, bassist and vocalist for the Washington, D.C. punk band the Most Secret Method, performing at the Black Cat in Washington, D.C. on March 13, 1997.
Baronner, Chris
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Levellism and the Method of Abstraction by
, 2008 The use of “levels of abstraction ” in philosophical analysis (levellism) has recently come under attack. In this paper, we argue that a refined version of epistemological levellism should be retained as a fundamental method, which we call the method of ...
The Method Of Abstraction +1 more
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