Results 91 to 100 of about 4,417,817 (254)

(Un)attractor black holes in higher derivative AdS gravity

, 2008
We investigate five-dimensional static (non-)extremal black hole solutions in higher derivative Anti-de Sitter gravity theories with neutral scalars non-minimally coupled to gauge fields. We explicitly identify the boundary counterterms to regularize the
Astefanesei, Dumitru, Banerjee, Nabamita, Dutta, Suvankar   +2 more
core   +1 more source

A simple and inexpensive haemozoin-based colorimetric method to evaluate anti-malarial drug activity

Malaria Journal, 2012
Background The spread of drug resistance in malaria parasites and the limited number of effective drugs for treatment indicates the need for new anti-malarial compounds.
Men Tran, Huy Nguyen, Trang Dai Thi, Shuaibu Mohammed, Hirayama Kenji, Kamei Kaeko   +5 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Three-section method for calculating internal force and deformation of cantilevered anti-slide pile

Yantu gongcheng xuebao, 2018
At present, the internal force and displacement of anti-slide piles are calculated on the basis of two sections: the loaded segment and the embedded segment (called "Two-section method").
SU Ai-jun1, HUO Xin 2, WANG Jie-tao 3, LU Zhi-chun 4, JIAO Shi-jie 1
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Anti-phase synchronization of phase-reduced oscillators using open-loop control

, 2011
In this letter, we present an elegant method to build and maintain an anti-phase configuration of two nonlinear oscillators with different natural frequencies and dynamics described by the sinusoidal phase-reduced model. The anti-phase synchronization is
A. Becker, A. I. Zecevic, A. L. Hodgkin, A. Pikovsky, A. T. Winfree, Dionisis Stefanatos, G. B. Ermentrout, I. Blekhman, J. Jalife, J. Keener, J.-S. Li, Jr-Shin Li, S. H. Strogatz, V. Jurdjevic, Y. Kuramoto   +14 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Integrated Jamming Perception and Parameter Estimation Method for Anti-interrupted Sampling Repeater Jamming

Leida xuebao
Interrupted Sampling Repeater Jamming (ISRJ) is a type of intra-pulse coherent jamming that can easily generate false targets resembling real ones, thus posing a severe threat to radar systems.
Rongqing WANG, Jingyang XIE, Biao TIAN, Shiyou XU, Zengping CHEN   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source