Results 51 to 60 of about 12,089,012 (278)

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

High-dimensional single-cell phenotyping unveils persistent differences in immune cell profiles between severe and moderate seasonal influenza

Frontiers in Immunology
BackgroundInfluenza viruses with pandemic potential and possible burden of post-viral sequelae are a global concern. To prepare for future pandemics and the development of improved vaccines, it is vital to identify the immunological changes underlying ...
Johanna Bodin, Gro Tunheim, Anja B. Kristoffersen, Tove K. Herstad, Eleonora Vianello, Mariëlle C. Haks, Suzanne van Veen, Torgun Wæhre, Anne-Marte B. Kran, Anne-Marte B. Kran, Sarah L. Lartey, Fan Zhou, Rebecca J. Cox, Rebecca J. Cox, Tom H. M. Ottenhoff, Anne M. Dyrhol-Riise, Anne M. Dyrhol-Riise, Unni C. Nygaard, Fredrik Oftung, Siri Mjaaland   +19 more
doaj   +1 more source

Use of capillary electrophoresis as a method development tool for classical gel electrophoresis [PDF]

, 1998
Capillary electrophoresis (CE) was used to optimize the buffer pH, ionic strength and sulfated cyclodextrin concentrations for enantiomeric separation of piperoxan.
Gratz, Samuel R., Stalcup, Apryll, Sutton, Richard M. C.   +2 more
core   +1 more source

Cognitive Functioning in Vorinostat‐Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba, Michelle Rozwadowski, Thomas Braun, April Rahrig, Edward Peres, Kirsten M. Williams, Vanessa Fabrizio, Julie‐An Talano, Carrie L. Kitko, Nicolas Parnell, Pavan Reddy, Sung Won Choi   +11 more
wiley   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

Evaluation of the Utility of Baseline Echocardiogram in Patients With Standard Risk Precursor B‐Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
Abstract Background A routine baseline echocardiogram is often obtained prior to anthracycline administration in children with cancer. The utility of baseline echocardiogram is unclear in patients with standard risk B‐cell acute lymphoblastic leukemia (SR B‐ALL) as their anthracycline cumulative dose is low.
Ziyad Alrajhi, Alice Pozza, Luc Mertens, Adam Paul Yan, Sarah Alexander   +4 more
wiley   +1 more source

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender, Lauren Pommert, Lori R. Backus, Andrea Bidwell, Courtney Blank, Erin H. Breese, Karen C. Burns, Adam Lane, Lynn H. Lee, Benjamin Mizukawa, Robin E. Norris, Maureen M. O'Brien, Daniel Peck, Christine Phillips, Thomas D. Ryan, Jennifer Young, Michael Absalon, John P. Perentesis   +17 more
wiley   +1 more source

Developing Adequate Communication of Waste Footprints of Products for a Circular Economy—A Stakeholder Consultation

Resources, 2018
Relatively few consumers are conscious of the waste generated in the course of producing the goods that they consume, although most are aware of the amount of waste they dispose of. This article reports on a small-scale survey (N = 28) among stakeholders
Rafael Laurenti, Michael Martin, Åsa Stenmarck   +2 more
doaj   +1 more source

IoT System Development Methods [PDF]

, 2017
This chapter presents an overview of system development methods (SDMs) dedicated for Internet of Things (IoT) systems. It summarizes IoT SDMs along with their process flows represented using Business Process Model and Notation. The chapter presents the characterization of these methods using the evaluation criteria.
Giray, G., Tekinerdogan, B., Tüzün, E.
openaire   +3 more sources

DEVELOPMENT THE METHOD OF THERMOMECHANICAL LOADING MANAGEMENT OF TRIBOLOGICAL CONTACT [PDF]

, 2018
At present, rail transport in connection with the economic situation is very important for solving the problems associated with increasing the efficiency and economy of the railway transport.
HORBUNOV, Nykolai, KOVTANETS, Tatiana, KOVTANETS’, Maksim, NOZHENKO, Elena   +3 more
core