Results 81 to 90 of about 12,089,012 (278)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Detection of anti-drug antibodies to aflibercept by enzyme-linked immunosorbent assay: Development and validation of the method

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Aflibercept is used to treat neovascular age-related macular degeneration, a leading cause of vision loss. Immunogenicity is one of the significant adverse effects that results in the production of anti-drug antibodies (ADAs).
I. V. Shevchenko, A. E. Lisova, A. A. Agafonova, K. A. Smolova, I. M. Alaeva, I. Yu. Zhukov, A. A. Kazarov, I. V. Lyagoskin   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A development and implementation of a tinnitus treatment method [PDF]

, 2013
Tinnitus is a physiological phenomenon where a person listens sounds which have not been generated by any external source. Today, many people suffer this condition.
Agüero, Pablo Daniel, Castiñeira Moreira, Jorge, González, Esteban Lucio, Moscardi, Graciela, Sajama, Elber Emanuel, Tulli, Juan Carlos, Uriz, Alejandro José   +6 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Morphological Forced Connection Method Application in the Development of Plered Ceramic Design [PDF]

, 2019
In Plered, the activity of making clay crafts has been carried out for generations. Located in the southern region of Purwakarta Regency, the pottery industry is located in Anjun Village, Citeko Village and Pamoyanan Village.
Muchlis, M. (Muchlis), Nurfita, R. (Rizki ), Pujiraharjo, Y. (Yoga ), Putri, S. A. (Sheila )   +3 more
core  

Phase-field-crystal models for condensed matter dynamics on atomic length and diffusive time scales: an overview [PDF]

, 2012
Here, we review the basic concepts and applications of the phase-field-crystal (PFC) method, which is one of the latest simulation methodologies in materials science for problems, where atomic- and microscales are tightly coupled. The PFC method operates
Artemev A., Brazowskii S. A., Choudhary M. A., Cross M. C., de Gennes P. G., Dholakia K., Dhont J. K.G., Doi M., Emmerich H., Emmerich H., Evans R., Freund L. B., Frey E., Gray C. G., Groot S. R.d., Gunton J. D., Gyula I. Tóth, György Tegze, Hansen J. P., Hartmut Löwen, Heike Emmerich, Kalikmanov V. I., Kelton K. F., László Gránásy, Pilipenko D., Pismen L. M., Raphael Wittkowski, Reichl L. E., Risken H., Shimoji M., Tegze G., Thomas Gruhn   +31 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Morphine and codeine in racing horse feed: is there reason for concern?

Arhiv za Higijenu Rada i Toksikologiju
Opiates such as morphine and codeine are substances often misused to improve the performance of racing horses during competitions and are therefore on the International Federation for Equestrian Sports’ list of prohibited substances.
Karačonji Irena Brčić, Jelača Tea, Jurič Andreja, Vrdoljak Ana Lucić   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source