Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Predictors of carotenoid status in New Zealand children using carotenoid reflection score: a cross-sectional study. [PDF]
Rapson J +5 more
europepmc +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Study on nutritional status and incidence of sarcopenia in elderly patients with chronic heart failure. [PDF]
Song S, Du H, Lu X, Luo B, Li Z.
europepmc +1 more source
Research on Optimized Methods for Dynamic Characteristic Retention and Artifact Removal in Blood Oxygen Signals [PDF]
Yingjun Deng
openalex +1 more source
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Fault-induced detection method for power supply lines in the cutting unit of coal shearer based on PIO-VMD-EDO. [PDF]
Wang Y +6 more
europepmc +1 more source
Characteristics of In-Vitro Starch Digestibility in Wheat Bread with Arabinoxylans, Baked Using Sourdough or Postponed Baking Methods [PDF]
Angelika Bieniek, Krzysztof Buksa
openalex +1 more source

