Results 221 to 230 of about 1,709,283 (288)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Exploring fibers with X-ray eyes. [PDF]

IUCrJ
Giannini C.
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Exploring the chaotic, sensitivity and wave patterns to the dual-mode resonant Schrödinger equation: application in optical engineering. [PDF]

Sci Rep
Muhammad J, Younas U, Yar M.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Bifurcation analysis and analytical traveling wave solutions of a sasa-satsuma equation involving beta, M-truncated and conformable derivatives using the EGREM method. [PDF]

Sci Rep
Munir F, Saad KM, Abbas M, Birhanu A, Hamanah WM, Nazir T.   +5 more
europepmc   +1 more source

An analytical approach to generating orbital maneuver sets for spacecraft on-orbit services. [PDF]

Sci Rep
Xue J, Zhao S, Yang M, Jiang Y, Zhang Y, Tao X.   +5 more
europepmc   +1 more source

Quantitative Stability Evaluation of Reconstituted Azacitidine Under Clinical Storage Conditions. [PDF]

Pharmaceuticals (Basel)
Ruga S, Lombardi R, Bocci T, Armenise M, Masullo M, Lamesta C, Bava R, Castagna F, Matarese E, Di Viesti MP, Biancofiore A, Liguori G, Palma E.   +12 more
europepmc   +1 more source

Sustainable High Corrosion Resistance in High-Concentration NaCl Solutions for Refractory High-Entropy Alloys with High Strength and Good Plasticity. [PDF]

Entropy (Basel)
Chen S, Liu X, Li C, Wang W, Yue X.
europepmc   +1 more source

Fractional order effects on solitary waves and chaotic regimes in the mKdV Burgers equation. [PDF]

Sci Rep
Islam MA, Rimu NN, Dey P.
europepmc   +1 more source