Results 181 to 190 of about 1,549,396 (218)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Developing Midlife Metacognitive Strategy Training (M-MCST) program: A feasibility study with middle-aged adults to evaluate the design, implementation, and impact of a novel program in fostering healthy cognitive aging. [PDF]

PLoS One
Rooha A, Swamy S, Jacob NL, Bajaj G, Chaudhary C, George VM, Bhat JS.   +6 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Faster Hamiltonian Monte Carlo by learning leapfrog scale: an offline randomized solution. [PDF]

Stat Comput
Wu C, Pudlo P, Robert CP, Stoehr J.
europepmc   +1 more source

Standardized In-house Protocol for Determining the Minimum Inhibitory Concentration (MIC) via Broth Microdilution for Natural Products Against Obligate Anaerobic Bacteria. [PDF]

Curr Protoc
Gonçalves DS, Santiago MB, Sousa LA, Martins CHG.   +3 more
europepmc   +1 more source

Multi-Element Characterization and Sustainability Assessment of Traditional Turkish Red Sugar Using Deep Eutectic Solvent Extraction and ICP-MS. [PDF]

Foods
Topraksever N.
europepmc   +1 more source

Time Series Segmentation in Adaptive Optics Ophthalmoscopy With Application to Flicker-Induced Vasodilation. [PDF]

Transl Vis Sci Technol
Vard A, Aissa A, Rossant F, Bloch I, Castro-Farias D, Chabriat H, Paques M.   +6 more
europepmc   +1 more source