Results 71 to 80 of about 1,334,154 (310)

Methodological and TNM Focus-Based Comparison of EGFR Mutation Status in Non-Small-Cell Lung Carcinomas

Journal of Cytology
Background: Epidermal growth factor receptor (EGFR) mutations in non-small-cell lung carcinomas (NSCLC) are a frequent class of driver mutations, and tyrosine kinase inhibitor (TKI) therapy provides considerable clinical benefits.
Yasemin Akca, Suna Erkilic
doaj   +1 more source

Inventory of personal factors influencing conditioned pain modulation in healthy people: a systematic literature review [PDF]

, 2015
Background: Conditioned pain modulation (CPM) is believed to play an important role in the development and exacerbation of chronic pain, because dysfunction of CPM is associated with a shift in balance between pain facilitation and pain inhibition.
Calders, Patrick, Crombez, Geert, Goubert, Dorien, Goudman, Lisa, Hermans, Linda, Meeus, Mira, Van Oosterwijck, Jessica   +6 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Effectiveness of early intervention programs for parents of preterm infants: a meta-review of systematic reviews [PDF]

, 2018
Background: Various intervention programs exist for parents of preterm babies and some systematic reviews (SRs) have synthesised the evidence of their effectiveness.
A Spittle, A Talmi, AJ Ferrari, AJ Sameroff, BJ Shea, C Day, EM Boyle, EO Boundy, F Borrell-Carrio, H Blencowe, IH Ravn, IP Landsem, J Brett, J McGregor, J Orton, J Petrie, J Vanderveen, JE Lawn, JM Kerstjens, Jogesh Kapadia, KM Benzies, L Hartling, Lesley Kilby, M Forcada-Guex, M Herd, ME Feinberg, ML Wang, MS Miles, Muhammad Chutiyami, NK Goyal, Pei-Ching Tseng, PI Kaaresen, Shuby Puthussery, T Evans, TN Raju, V Smith, V Smith, X Zhang   +37 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The Use of the Binding Argument in the Debate about Location [PDF]

, 2017
In this paper I inquire into the methodological status of one of the arguments that have figured prominently in contemporary debates about the semantics of a variety of expressions, the so-called “Binding Argument”.
Zeman, Dan
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Methodological Status of Agent-Based Simulations [PDF]

SSRN Electronic Journal, 2002
In this paper I give a tentative assessment of the methodological status of agent based simulations. I first show under which conditions ABS can be a complement to traditional modelling. I then consider whether they can be held as a sound methodology of their own.
openaire   +1 more source

Jerzy Kmita’s Methodological Interpretation of Karl Marx’s Philosophy. From Ideology to Methodological Concepts [PDF]

, 2017
The article presents J. Kmita’s methodological interpretation of selected cognitive methods used by K. Marx. Those methods were (and I believe they still are) significant for the social sciences and the humanities, even a ...
Pałubicka, Anna
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