Results 201 to 210 of about 3,716,507 (339)

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Generative design as a tool to analyse the uncertain loading regimes of intricate skeletal structures. [PDF]

J R Soc Interface
Racy JM, Boom B, Summers A.
europepmc   +1 more source

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Advances in human pluripotent stem cell reporter systems

iScience
Summary: The capability of human pluripotent stem cells (hPSCs) to self-renew and differentiate into any cell type has greatly contributed to the advancement of biomedicine.
Lesly Puspita, Virginia Blessy Juwono, Jae-won Shim   +2 more
doaj  

Cadmium exposure and risk of pancreatic cancer: Systematic review and meta-analysis. [PDF]

PLoS One
Soleimani Y, Nayebi M, Mahmoudi S, Daraei M, Khorsand S, Jahazi MA, Farsi MY, Khalafi F, Varseh M, Jarrahi ZM, Soleimani M, Massoudnia K, Karamian S, Jarrahi AM.   +13 more
europepmc   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

A microfluidic platform for anterior-posterior human endoderm patterning via countervailing morphogen gradients in vitro

iScience
Summary: Understanding how morphogen gradients spatially pattern tissues is a fundamental question in developmental biology but can be difficult to directly address using conventional approaches.
Leeya Engel, Kevin J. Liu, Kiara W. Cui, Eva L. de la Serna, Vipul T. Vachharajani, Carolyn E. Dundes, Sherry Li Zheng, Manali Begur, Kyle M. Loh, Lay Teng Ang, Alexander R. Dunn   +10 more
doaj  

Perfluorobutane Sulfonate (PFOS) Accumulation in Tissues of <i>Cherax quadricarinatus</i> and Its Toxicity Mechanism. [PDF]

Toxics
Hong S, Zhu T, Liu C, Li Y, Song W, Wang X, Liu X, Wang H, Li K, Cao X, Yao C, Lv W.   +11 more
europepmc   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Proteins and pathways involved in inflammation are longitudinally associated with total body bone mineral density among primarily Hispanic overweight/obese adolescents and young adults. [PDF]

J Bone Miner Res
Beglarian E, Chen JC, Li Z, Costello E, Wang H, Hampson H, Alderete TL, Chen Z, Valvi D, Rock S, Chen W, Rianon N, Aung MT, Gilliland FD, Goran MI, McConnell R, Eckel SP, Lee M, Conti DV, Goodrich JA, Chatzi L.   +20 more
europepmc   +1 more source