Results 231 to 240 of about 3,716,507 (339)

Healing and leishmanicidal activity of <i>Zanthoxylum rhoifolium</i> Lam. [PDF]

Front Chem
Correa-Barbosa J, Brígido HPC, Matte BF, Campos PS, Lamers ML, Sodré DF, Nascimento PHC, Ferreira GG, Vale VV, Marinho AMDR, Siqueira JES, Coelho-Ferreira MR, Monteiro MC, Dolabela MF.   +13 more
europepmc   +1 more source

Cost‐effective and simple flow cytometry quantification of receptor‐mediated autophagy using fluorescent tagging

FEBS Open Bio, Volume 15, Issue 4, Page 587-598, April 2025.
Mitophagy, the selective degradation of damaged mitochondria, is crucial for cellular health and function. This study introduces a rapid and efficient flow cytometry method using GFP‐BNIP3L/NIX to accurately quantify mitophagy. Our approach can be adapted to use any fluorescent‐tagged selective autophagy receptor, enabling direct and rapid analysis of ...
Mija Marinković, Ana Rožić, Denis Polančec, Ivana Novak   +3 more
wiley   +1 more source

Inhibition potential of margolonone and isomargolonone against the dengue virus protease using molecular modeling approaches. [PDF]

Front Bioinform
Choudhir G, Iram F, Israil, Shahid M, Shamsi A, Hassan MI, Islam A.   +6 more
europepmc   +1 more source

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

FEBS Open Bio, Volume 15, Issue 5, Page 699-713, May 2025.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo, Klaudia Jaczynska, Christian Rosenmund   +2 more
wiley   +1 more source

Machine Learning Scoring Reveals Increased Frequency of Falls Proximal to Death in Drosophila melanogaster. [PDF]

J Gerontol A Biol Sci Med Sci
Mattins F, Nagrath S, Fan Y, Manea TKD, Das S, Shankar A, Tower J.   +6 more
europepmc   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, Volume 15, Issue 5, Page 836-855, May 2025.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Initial validity and reliability testing of the SGBA-5. [PDF]

PLoS One
Putman A, Cole A, Dogra S.
europepmc   +1 more source

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, Volume 15, Issue 5, Page 822-835, May 2025.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Turning lances into shields: flower mantids stretch their raptorial forelegs to avert and deflect predator attack. [PDF]

Proc Biol Sci
Li Y, Liu Q, Chen Z, Liang L, Wang Z, Duan Y, Song F, Cai W, Ge J, Li H, Tian L.   +10 more
europepmc   +1 more source