Results 151 to 160 of about 823,228 (211)
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Some of the next articles are maybe not open access.
2020
It will be argued that this research method is indicated when research interests focus on the detailed analysis of conscious as well as unconscious intrapsychic and interpersonal processes of single persons interacting with important others in groups. Dependent on the research design this qualitative method can be used in single case studies as well as
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It will be argued that this research method is indicated when research interests focus on the detailed analysis of conscious as well as unconscious intrapsychic and interpersonal processes of single persons interacting with important others in groups. Dependent on the research design this qualitative method can be used in single case studies as well as
openaire +2 more sources
2021
This chapter assesses observational methods. What distinguishes observational methods, and particularly participant observation (PO), from other data-gathering methods is, among others, that it privileges direct observation over the use of instruments. This implies that the observation is likely to be holistic, in the sense of involving the five senses,
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This chapter assesses observational methods. What distinguishes observational methods, and particularly participant observation (PO), from other data-gathering methods is, among others, that it privileges direct observation over the use of instruments. This implies that the observation is likely to be holistic, in the sense of involving the five senses,
openaire +2 more sources
Disturbance Observers: Methods and Applications. I. Methods
Automation and Remote Control, 2020zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Boris R. Andrievsky, Igor B. Furtat
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A Method for Observing Symptoms and Attitudes
British Journal of Social and Clinical Psychology, 1965A method is described for obtaining information about subjective symptoms and attitudes towards them. It was developed, for epidemiological purposes, from a procedure used by Shapiro in his personal questionnaire technique. Subjects are required to choose between pairs of statements representing different degrees of severity of each symptom.
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